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A Technology Resource for Polymer Microelectrode Arrays

聚合物微电极阵列的技术资源

基本信息

批准号：
10669205
负责人：
Ellis Meng
金额：
$ 122.54万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669205
关键词：
Acceleration Address Adoption BRAIN initiative Behavioral Brain Chronic Clinical Communities Custom Data Devices Diameter Documentation Electrodes Electrophysiology (science)Ensure Evaluation FDA approved Feedback Goals Grant Histology Imaging technology Implant Masks Mechanics Metals Methodology Microelectrodes Modeling Monitor Neurosciences Neurosciences Research Operative Surgical Procedures Outcome Penetration Performance Polymers Printed Media Process Property Quality Control Rattus Recording of previous events Reproducibility Research Research Personnel Resources Running Semiconductors Services Silicon Site Specific qualifier value Surface Surface Properties Techniques Technology Testing Time Tissues Training Training Activity Vertebral column Work base cost density design digital media experimental study fabrication flexibility high standard implantation in vivo instructor integrated circuit interest medical implant meetings metal oxide nervous system disorder neural neuroprosthesis neurotechnology next generation optical imaging optogenetics parylene parylene C prototype quality assurance symposium testing services translational neuroscience web site

项目摘要

The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their integrated into neuroscience research practice. Such polymer neural interfaces are mechanically compliant to promote stability of the device-tissue interface and versatile in that both surface and penetrating electrode arrays can be produced with the same technology. To accomplish their dissemination and integration, a resource will be created that offers the ability to customize electrode designs for their applications that are compatible with other recording and stimulation technologies and imaging technologies. The state-of-the-art polymer probes with high channel count will be made available to select users through project proposals selected with the input of a steering committee and to the broader community as prototypes on shared multi-project processing runs. Importantly, devices produced through user engagement will be functionally tested and ready to implant. The multi-project wafer processing runs will allow for small numbers of custom devices from multiple users to be produced on a single mask set which will allow users to debug and perform design adjustments and allow the resource to efficiently utilize wafer real estate. The resource also offers a testing service to validate electrode arrays made by external users. The successful in vivo implementation of interface technologies is dependent of their repeatable construction and reliable performance; these may be difficult to attain in small batch prototypes and even in commercially produced devices because of lack of testing capabilities or expertise. Device testing services will ensure rigor, reproducibility, and transparency for the benefit of the user community. The testing approach will be comprehensive, beginning at the materials level and progressing to the interface, interconnections, and packaging. Testing will include techniques that examine surface properties, material properties, mechanical performance, electrical and electrochemical performance, and lifetime testing. As needed, testing will be tailored for each project as dictated by its end use requirements. The testing methodologies will be rigorously documented and also disseminated. To facilitate adoption of technologies by users, the resource will offer onsite training on how to implement electrode arrays in vivo in rat. The resource seeks to enable BRAIN Initiative investigators and the broader community to achieve large scale recordings that will impact fundamental neuroscience research and next generation neuroprosthetic platforms for the treatment of multiple neurological disorders and conditions.

该提案的目的是传播聚合物微电极阵列，并促进其融入神经科学研究实践。这样的聚合物神经接口机械地顺应性以促进装置-组织界面的稳定性，可以用相同的技术生产穿透电极阵列。来完成他们的传播和整合，将创建一个资源，提供定制电极的能力与其他记录和刺激技术兼容的应用设计，成像技术。将提供具有高通道数的最先进的聚合物探针通过在指导委员会的投入下选定的项目提案选择用户，并向更广泛的社区作为共享多项目处理运行的原型。重要的是，通过将对用户参与度进行功能测试并准备植入。多项目晶圆加工运行将允许多个用户在单个掩模组上生产少量定制设备这将允许用户调试和执行设计调整，并允许有效地利用资源华夫真实的地产。该资源还提供测试服务，以验证外部用户制作的电极阵列。的接口技术在体内的成功实施依赖于它们的可重复构造和可靠的性能;这些可能很难在小批量原型中实现，甚至在由于缺乏测试能力或专业知识，商业化生产的设备。Device testing services 将确保严格性、可重复性和透明度，以造福用户社区。测试方法将是全面的，从材料一级开始，逐步到接口，互连和封装。测试将包括检查表面特性、材料性能、机械性能、电气和电化学性能以及寿命测试。作为根据需要，将根据每个项目的最终使用要求，为每个项目量身定制测试。测试将严格记录和传播各种方法。为了促进用户采用技术，该资源将提供现场培训，介绍如何在大鼠体内实现电极阵列。该资源旨在使大脑倡议调查人员和更广泛的社区实现大规模记录，这将影响基础神经科学用于治疗多种神经系统疾病的研究和下一代神经假体平台和条件