Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis

精准医学生物模块多尺度系统生物技术资源中心(CBM2) 培训和传播：标度感：使用混合标度系统进行稀有生物标志物分析 摘要/摘要 精准医学生物模块多尺度系统中心(CBM2)寻求开发创新 用于液体活检标记物分析的混合标记物，通过识别 适当的临床治疗策略，根据患者的分子组成指导患者 疾病。这种被称为“精准医学”的方法将是该中心培训和 传播(T&D)的努力，通过利用在 中心的技术研究和开发(T R&D)项目。该中心将参加培训和 教育赞助人(即非中心附属研究人员、合作者、学生、医生和潜在客户 行业合作伙伴)关于中心技术、“如何制造”和“如何使用”。发现和发现 来自研发和发展的知识将有效地传播到科学界和医生 参与临床研究。CBM2将利用中心附属机构内的现有资源 机构(昆士兰大学、北卡罗来纳大学和路易斯安那州立大学)让生物医学界熟悉其广泛的能力； 例子包括位于所有三个校区的最先进的纳米制造资源。传播 中心发现将通过引人注目的出版物、专利和周围初创企业的形成而得到加强 中心IP。该中心将教育非科学社区关于精准医学和 它在改善患者护理和疾病管理方面提供了好处。传播将随之而来 传统路线和非传统路线，如出版物和在国家/国际会议上的演讲 会议以及强大的网站、社交媒体和在线教学视频。我们的访问学者项目 让非附属研究人员参与该中心的研发项目将有助于传播。 该中心研发工作的共同主题将是“规模感：使用混合比例系统来应对罕见事件” 生物标志物分析“。CBM2的S培训的目标将是传达这样的信息：生物系统(即， 液体活组织检查标记物，如cfDNA、miRNA、蛋白质、EVS和细胞)跨越多种大小，且生物技术 研究经常涉及实验，这些实验必须将不同的生物长度尺度连接在一起，以实现 为他们的分析提供有效的集成系统。培训工作将包括讨论如何定义 研究领域基于感兴趣的生物系统的特征大小和相关的时间尺度 正在调查的现象(即反应、分离、扩散)。T&D活动将寻求回答问题 这与在微米和纳米尺度环境中发生的过程之间的差异有关。何以 在几十微米或纳米以下执行时，生物学是不同的吗？能否对这些流程进行建模？ 如何使用不同长度尺度的观测值来设计不同尺寸的流体系统？手- On实验将被设计成向各方传递细胞、电动汽车和DNA的大小以及设备如何 被开发来分析它们。

TITLE: Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine Training and Dissemination: Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis Abstract/Summary The Center of BioModular Multi-Scale Systems for Precision Medicine (CBM2) seeks to develop innovative mixed-scale tools for the analysis of liquid biopsy markers that aid in managing patients' diseases by identifying appropriate clinical treatment strategies that benefit patients guided by the molecular composition of their disease. This approach, known as ”Precision Medicine,” will be the focus of the Center's Training and Dissemination (T&D) efforts by leveraging the compelling research taking place under the umbrella of the Center's Technology Research and Development (TR&D) projects. The Center will participate in training and educating patrons (i.e., non-Center affiliated researchers, collaborators, students, physicians, and potential industry partners) on Center technologies, “How to Make It”, and “How to Use It.” Findings and discoveries stemming from the TR&Ds will be efficiently disseminated into the scientific community and to physicians involved in clinical research. CBM2 will take advantage of existing resources within the Center's affiliated institutions (KU, UNC, and LSU) to familiarize the biomedical community with its extensive capabilities; an example includes state-of-the-art nanofabrication resources located at all three campuses. Dissemination of Center discoveries will be enhanced by compelling publications, patents, and the formation of startups around Center IP. The Center will educate a non-scientific community on the subject of Precision Medicine and the benefits it offers in terms of the improvement of patient care and disease management. Dissemination will follow traditional routes and those not so traditional, such as publications and presentations at national/international meetings as well as a robust website, social media, and online instructional videos. Our visiting scholar program to engage non-affiliated researchers in the Center's TR&D projects will facilitate dissemination. The common theme of the Center's T&D efforts will be, “Sense-of-Scale: the use of mixed-scale systems for rare biomarker analysis”. CBM2's objectives in training will be to convey the message that biological systems (i.e., liquid biopsy markers such as cfDNA, miRNA, proteins, EVs, and cells) span many sizes and that biotechnology research frequently involves experiments that must link different biological length scales together to realize the delivery of effective integrated systems for their analysis. Training efforts will involve discussions on defining research areas based on the characteristic size of the biological system of interest and time-scales of relevant phenomena (i.e., reactions, separations, diffusion) under investigation. T&D events will seek to answer questions related to differences between processes that take place in a micro- and nano-scale environment. How does biology differ when executed below tens of micrometers or nanometers? Can these processes be modeled? How can observables in different length scales be used for designing fluidic systems with different sizes? Hands- on experiments will be designed that will convey to parties the size of cells, EVs, and DNA and how devices can be developed to analyze them.