Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis

标题：精准医学生物模块化多尺度系统（CBM 2）生物技术资源中心 培训和传播：规模感：混合规模系统用于稀有生物标志物分析 摘要/概要 精准医学生物模块化多尺度系统中心（CBM 2）旨在开发创新的 用于分析液体活检标记物的混合尺度工具，通过识别 适当的临床治疗策略，使患者受益，由其分子组成指导， 疾病这种被称为“精准医学”的方法将成为该中心培训的重点， 传播（T&D）的努力，通过利用在全球范围内进行的引人注目的研究， 中心的技术研究和开发（TR&D）项目。中心将参加培训， 教育顾客（即，非中心附属研究人员，合作者，学生，医生和潜在的 行业合作伙伴）的中心技术，“如何使它”，以及“如何使用它”。调查结果和发现 来自TR& D的信息将有效地传播给科学界和医生 参与临床研究。CBM 2将利用中心附属机构的现有资源， 研究机构（KU，ESTA和路易斯安那州立大学），以熟悉其广泛的能力生物医学界; 示例包括位于所有三个校区的最先进的纳米制造资源。传播 中心的发现将通过引人注目的出版物，专利和周围创业公司的形成来加强 中心IP。该中心将为非科学界提供有关精准医学和 它在改善病人护理和疾病管理方面提供的好处。随后将进行传播 传统途径和非传统途径，如在国家/国际会议上出版和介绍 会议以及强大的网站，社交媒体和在线教学视频。我们的访问学者项目 让非附属研究人员参与中心的研发项目将有助于传播。 该中心的T&D工作的共同主题将是，“规模感：使用混合规模系统， 生物标志物分析”。第二次建立信任措施的培训目标将是传达生物系统（即， 液体活检标记物，如cfDNA、miRNA、蛋白质、EV和细胞）跨越许多尺寸，并且生物技术 研究经常涉及必须将不同的生物长度尺度联系在一起以实现 提供有效的综合分析系统。培训工作将包括讨论如何界定 基于感兴趣的生物系统的特征大小和相关时间尺度的研究领域 现象（即，反应、分离、扩散）。T&D活动将寻求回答问题 与发生在微米和纳米尺度环境中的过程之间的差异有关。如何 在几十微米或纳米以下执行时，生物学会有什么不同？这些过程可以被模拟吗？ 如何将不同长度尺度的观测值用于设计具有不同尺寸的流体系统？手- 将设计一系列实验，向各方传达细胞、电动汽车和DNA的大小，以及设备如何 来分析它们。

TITLE: Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine Training and Dissemination: Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis Abstract/Summary The Center of BioModular Multi-Scale Systems for Precision Medicine (CBM2) seeks to develop innovative mixed-scale tools for the analysis of liquid biopsy markers that aid in managing patients' diseases by identifying appropriate clinical treatment strategies that benefit patients guided by the molecular composition of their disease. This approach, known as ”Precision Medicine,” will be the focus of the Center's Training and Dissemination (T&D) efforts by leveraging the compelling research taking place under the umbrella of the Center's Technology Research and Development (TR&D) projects. The Center will participate in training and educating patrons (i.e., non-Center affiliated researchers, collaborators, students, physicians, and potential industry partners) on Center technologies, “How to Make It”, and “How to Use It.” Findings and discoveries stemming from the TR&Ds will be efficiently disseminated into the scientific community and to physicians involved in clinical research. CBM2 will take advantage of existing resources within the Center's affiliated institutions (KU, UNC, and LSU) to familiarize the biomedical community with its extensive capabilities; an example includes state-of-the-art nanofabrication resources located at all three campuses. Dissemination of Center discoveries will be enhanced by compelling publications, patents, and the formation of startups around Center IP. The Center will educate a non-scientific community on the subject of Precision Medicine and the benefits it offers in terms of the improvement of patient care and disease management. Dissemination will follow traditional routes and those not so traditional, such as publications and presentations at national/international meetings as well as a robust website, social media, and online instructional videos. Our visiting scholar program to engage non-affiliated researchers in the Center's TR&D projects will facilitate dissemination. The common theme of the Center's T&D efforts will be, “Sense-of-Scale: the use of mixed-scale systems for rare biomarker analysis”. CBM2's objectives in training will be to convey the message that biological systems (i.e., liquid biopsy markers such as cfDNA, miRNA, proteins, EVs, and cells) span many sizes and that biotechnology research frequently involves experiments that must link different biological length scales together to realize the delivery of effective integrated systems for their analysis. Training efforts will involve discussions on defining research areas based on the characteristic size of the biological system of interest and time-scales of relevant phenomena (i.e., reactions, separations, diffusion) under investigation. T&D events will seek to answer questions related to differences between processes that take place in a micro- and nano-scale environment. How does biology differ when executed below tens of micrometers or nanometers? Can these processes be modeled? How can observables in different length scales be used for designing fluidic systems with different sizes? Hands- on experiments will be designed that will convey to parties the size of cells, EVs, and DNA and how devices can be developed to analyze them.