MICROBIOLOGY (WHOLE GENOME SEQUENCING - TRACK 4)

项目总结： 该项目的主要目标是通过执行全基因组来支持食品和药物管理局(FDA 对从人和/或动物性食品中收集的分离菌株进行细菌病原体的测序，从而辅助追踪 密歇根州各地的反向调查。在这个项目中，MDHHS将测试大约400个分离物 通过全基因组测序从人类食物、动物性食物、环境和水样本中提取并上载 结果实时传输到NCBI-NIH数据库。该实验室将参与GenomeTrakr网络。 参与的活动包括会议、电话会议、能力测试和帮助开展以下活动 来自网络合作伙伴的溢出测试。一名微生物学家还将出席GenomeTrakr年度会议和 一年一度的LFFM面对面会议。加入GenomeTrakr网络将增加MDHHS的 能够比较和分析将改善和加速疫情爆发的序列 调查。实验室常规进行单核细胞增多性李斯特氏菌、沙门氏菌、志贺氏菌的测序 产生毒素的大肠杆菌、弯曲杆菌和弧菌，但也能够对其他可能是 FDA对此感兴趣。

PROJECT SUMMARY: The primary goal of this project is to support Food and Drug Administration (FDA) by performing whole genome sequencing on isolates collected from human and or animal food for bacterial pathogens thereby assisting trace back investigations across the State of Michigan. For this project MDHHS will test approximately 400 isolates from human food, animal food, environmental and water samples by Whole Genome Sequencing and upload the results in real-time to NCBI-NIH database. The laboratory will participate in the GenomeTrakr network. Participation will include meetings, conference calls, proficiency testing and helping with activities such as overflow testing from network partners. A microbiologist will also attend an annual GenomeTrakr meeting and the annual LFFM face-to-face meeting. Participating in the GenomeTrakr network will increase MDHHS’ capabilities and ability to compare and analyze sequences that will improve and accelerate outbreak investigations. The laboratory routinely performs sequencing for Listeria monocytogenes, Salmonella, Shiga toxin-producing E.coli, Campylobacter, and Vibrio but is also able to sequence other organisms that may be of interest to FDA.