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7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base Tumors

7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base Tumors
颅底肿瘤内镜切除的 7T 神经外科标测方案
批准号:
10175768
负责人:
Priti Balchandani
金额:
$16.95万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-08-01 至 2021-03-31
关键词:
2019-nCoVAddressAdministrative SupplementAdult Respiratory Distress SyndromeAgeAnatomyBlood VesselsBrainBrain InjuriesBrain StemBrain regionCOVID-19Cancer PatientChinaClinicalControl GroupsCoronavirusDatabasesDiagnosisDiffusionDiseaseEncephalopathiesExcisionFatality rateFunctional Magnetic Resonance ImagingFunctional disorderGenderGoalsHeadacheHealthHealth systemHemorrhageHippocampus (Brain)ImageImage AnalysisImaging TechniquesInfectionInformaticsInvadedLightLinkLungMRI ScansMagnetic Resonance ImagingMeasurementMeasuresMethodsMiddle East Respiratory Syndrome CoronavirusMultimodal ImagingNasal cavityNauseaNervous system structureNeuraxisNeurologicNeurologic EffectNeurologic SymptomsNeuropsychologyOlfactory NerveOutcomePathogenicityPathologyPathway AnalysisPatient SelectionPatientsProspective StudiesProtocols documentationRadiologic FindingRecoveryReportingResolutionRespirationRespiratory CenterRespiratory Signs and SymptomsRespiratory SystemRespiratory distressRestRetrospective StudiesSARS coronavirusSample SizeScanningSkull Base NeoplasmsSmell PerceptionStrokeStructureSurvivorsTechniquesTestingThalamic structureTimeTravelUnited States National Institutes of HealthVagus nerve structureVentilatorVirusVirus DiseasesWorkbrain abnormalitiesbrain tissuebrain volumecancer diagnosiscohortcontrast enhancedcytokine release syndromedesignfallsgraph theoryimprovedinsightinterestmagnetic fieldmalignant neurologic neoplasmsmental statemultimodalitynervous system disorderneuroimagingolfactory bulbpatient populationpatient subsetsrecruitrespiratoryresponsetargeted imagingtooltractographyventilation

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英文摘要
Project Summary Although neurological symptoms are being observed in a high number of COVID-19 patients, a prospective study aimed at scanning recovered COVID-19 patients with advanced multi-modal neuroimaging methods has yet to be performed. There is much to be learned about the persisting effects of the SARS-CoV-2 virus on the central nervous system, and high-resolution magnetic resonance imaging (MRI) is the ideal non-invasive tool to reveal these effects as well as mechanisms of infection. In this work, we will leverage the high resolution and enhanced contrasts offered by multi-modal 7 Tesla (7T) imaging to study the structural, vascular, functional, and connectomic changes in the brain related to the pathophysiology of COVID-19. In particular, we will reveal, in unprecedented detail, brain abnormalities resulting from the SARS-CoV-2 infection as well as shine a brighter light on possible links to loss of respiratory drive due to viral infection through the brain stem. Imaging findings will be correlated to clinical neurological symptoms and neuropsychological measures. Three patient subgroups will be recruited for our prospective study: non-cancer patients with neurological symptoms who did not require a ventilator, cancer patients with neurological symptoms who did not require a ventilator, and patients who had severe respiratory distress and required ventilation. A retrospective study will also be performed on clinical brain MRI scans for a group of COVID-19 patients with neurological symptoms, seen at Mount Sinai Health System, and outcomes of this analysis will aid in patient selection for the 7T study and additional analysis of persisting versus transient neurological effects. Our study falls within the scope of our R01 application on “7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base Tumors” as we are applying similar multimodal 7T imaging techniques to reveal detailed anatomy in the brain and to characterize effects of disease in both studies. We will simply extend the cohort to include COVID-19 recovered patients and further optimize imaging in the brain stem which will be applicable to both studies. Our study aligns with the goals of the Notice of Special Interest announced by the NCI for administrative supplements on COVID-19 as it addresses potential for differential responses among diverse cancer patient populations to SARS-CoV-2 infection or COVID-19 disease in central nervous system.
期刊论文(29)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1371/journal.pone.0283614
发表时间: 2023
期刊: PloS one
影响因子: 3.7
作者: []
通讯作者:
Ultrahigh field MR Neuroimaging.
超高场磁共振神经成像。
DOI: 10.1097/rmr.0000000000000210
发表时间: 2019
期刊: Topics in magnetic resonance imaging : TMRI
影响因子: --
作者: [Verma,Gaurav, Balchandani,Priti]
通讯作者: Balchandani,Priti
Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla.
7特斯拉的癫痫患者的海马的子场特异性拖拉学。
DOI: 10.1016/j.seizure.2018.09.005
发表时间: 2018-11
期刊: Seizure
影响因子: --
作者: [Rutland JW, Feldman RE, Delman BN, Panov F, Fields MC, Marcuse LV, Hof PR, Lin HM, Balchandani P]
通讯作者: Balchandani P
Hippocampal subfield-specific connectivity findings in major depressive disorder: A 7 Tesla diffusion MRI study.
重度抑郁症中海马亚区特异性连接的发现:一项 7 特斯拉扩散 MRI 研究。
DOI: 10.1016/j.jpsychires.2019.02.008
发表时间: 2019
期刊: Journal of psychiatric research
影响因子: 4.8
作者: [Rutland,JohnW, Brown,Stephanie, Verma,Gaurav, Feldman,RebeccaE, Sharma,Himanshu, Markowitz,Matthew, Schneider,Molly, Delman,BradleyN, Murrough,James, Balchandani,Priti]
通讯作者: Balchandani,Priti
13
    Gut-brain axis in Alzheimer's disease: translational 7T MRI markers and underlying mechanisms
    • 批准号:
      10901013
    • 项目类别:
    • 资助金额:
      $81.01万
    • 财政年份:
      2023
    • 负责人:
      Priti Balchandani
    • 依托单位:
    Use of 7T multimodal imaging to detect brain changes associated with light therapy in persons with mild cognitive impairment and mild Alzheimer's Disease
    Visualizing trigeminal neuralgia at 7 Tesla: Advancing etiological understanding and improving future clinical imaging protocols
    Use of 7T multimodal imaging to detect brain changes associated with light therapy in persons with mild cognitive impairment and mild Alzheimer's Disease
    海外基金