Vocal cord tissue engineering: Pre-clinical scale-up
声带组织工程:临床前放大
基本信息
- 批准号:10174851
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAdipose tissueAdultAdverse eventAnimal ModelAnimalsAutologousAutopsyCanis familiarisCellsChemicalsChronicCicatrixClinical DataCommunication impairmentDataData CollectionDepositionDevelopmentEmotionalEndoscopyEvaluationExcisionExtracellular MatrixFailureFamily suidaeFatigueFibrinFibrosisFillerGastroesophageal reflux diseaseGoalsGrantHead and Neck CancerHumanHydrogelsImmunosuppressionImpairmentImplantInflammationInhalationInjuryIntentionInvestigational New Drug ApplicationLaboratoriesLaryngeal DiseasesLarynxMalignant neoplasm of larynxMammalsMeasuresMethodsModelingOccupationalOccupationsOperative Surgical ProceduresOryctolagus cuniculusOutcomeOutcome MeasurePerioperativePerioperative CarePhonationPilot ProjectsPostoperative ComplicationsPostoperative PeriodPreparationRadiation therapyRecoveryRegenerative MedicineReproducibilityResearchSafetySmokeSocial InteractionSteroidsStructureTechniquesTechnologyTimeTissue EngineeringTissue GraftsTissuesTranslationsTraumaVeteransVisualVoiceVoice DisturbancesVoice QualityWorkbaseblood productexperiencehealingimmunosuppressedimplantationimprovedimproved functioninginjuredmesenchymal stromal cellmultipotent cellphase I trialpre-clinicalpreclinical studypreclinical trialpressureprimary outcomerepairedsafety and feasibilityscaffoldscale upsmoke inhalationsocialtranslation to humansvibrationvocal cordvocalizationwoundwound healing
项目摘要
Veterans suffering loss of the larynx's vocal fold cover due to trauma or
laryngeal cancer can suffer disabling voice difficulties, and treatment options are
limited. A vibrating replacement tissue would revolutionize the treatment of
laryngeal disorders. The work described in this proposal characterizes and
optimizes a tissue-engineered Cell-based Outer Vocal cord Replacement (COVR).
Adult human multipotent cells isolated from adipose tissue are cultured within
fibrin hydrogel derived from the blood product cryoprecipitate. The result is a
completely autologous three-dimensional tissue substitute. Upon implantation in
rabbits, this construct healed well and produced normal short-term vibration for
voicing.
The COVR construct will now be introduced in a large animal model in
preparation for human translation. This proposed research will assess the
feasibility, safety, and efficacy of the tissue-engineered implant. Mechanisms of
action will also be assessed by determining the fate of the implanted cells, and the
effect on extracellular matrix and inflammation. Human cells will be implanted
with immunosuppression. A canine model is planned because extensive prior
laryngeal work has been performed in canines, providing ample data on normal
phonation. If canines are impossible, a porcine model would also allow scale-up
to large mammals and detailed study of the wound healing.
Completion of the proposed research will determine whether the COVR
meets safety and efficacy requirements to proceed with a larger trial. The goal is
to restore normal voicing without adverse events. If successful outcomes occur in
this pilot study, a larger trial will be performed with the intention of generating
pre-clinical data for FDA application.
退伍军人遭受损失的喉的声带覆盖由于创伤或
喉癌可能会导致发音困难,治疗方案包括
有限公司振动替代组织将彻底改变
喉部疾病本提案所述工作的特点是,
优化了组织工程化的基于细胞的外声带替换(COVR)。
将从脂肪组织分离的成人多能细胞在培养皿中培养。
来源于血液制品冷沉淀物的纤维蛋白水凝胶。其结果是一个
完全自体的三维组织替代物。植入后,
兔子,这种结构愈合良好,并产生正常的短期振动,
发声
COVR构建体现在将被引入到一个大型动物模型中,
为人工翻译做准备。这项研究将评估
组织工程植入物的可行性、安全性和有效性。机制
还将通过确定植入细胞的命运来评估作用,
对细胞外基质和炎症的影响。人体细胞将被植入
免疫抑制。计划建立一个犬模型,
在犬中进行了喉部工作,提供了关于正常
发声如果犬科动物是不可能的,那么猪的模型也可以扩大规模
对大型哺乳动物进行了详细的研究。
完成拟议的研究将决定COVR是否
符合安全性和有效性要求,以便进行更大规模的试验。目标是
以恢复正常发声而没有不良事件。如果成功的结果发生在
这项试点研究,一个更大的试验将进行的意图,产生
用于FDA申请的临床前数据。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Objective Assessment of Porcine Voice Acoustics for Laryngeal Surgical Modeling.
喉部手术模型猪声学的客观评估。
- DOI:
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Schlegel,Patrick;Wong,Kirsten;Aker,Mamdouh;Alhiyari,Yazeed;Long,Jennifer
- 通讯作者:Long,Jennifer
Extubation and the Risks of Coughing and Laryngospasm in the Era of Coronavirus Disease-19 (COVID-19).
冠状病毒病 19 (COVID-19) 时代的拔管以及咳嗽和喉痉挛的风险。
- DOI:10.7759/cureus.8196
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Sibert,KarenS;Long,JenniferL;Haddy,StevenM
- 通讯作者:Haddy,StevenM
Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2.
- DOI:10.3390/surgeries2040038
- 发表时间:2021-12
- 期刊:
- 影响因子:0
- 作者:Wong K;Damrose E;Long J
- 通讯作者:Long J
Decontamination Methods for Reuse of Filtering Facepiece Respirators.
- DOI:10.1001/jamaoto.2020.1423
- 发表时间:2020-08-01
- 期刊:
- 影响因子:0
- 作者:Su-Velez BM;Maxim T;Long JL;St John MA;Holliday MA
- 通讯作者:Holliday MA
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Jennifer L Long其他文献
Laryngotracheal Stenosis as a Complication of Photodynamic Therapy
喉气管狭窄作为光动力治疗的并发症
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Irene Kim;Jennifer L Long - 通讯作者:
Jennifer L Long
Future Directions in Dysphagia Treatment
吞咽困难治疗的未来方向
- DOI:
10.1016/b978-0-323-56930-9.00025-5 - 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Jennifer L Long;D. Chhetri - 通讯作者:
D. Chhetri
Laryngeal Tissue Engineering Using Rabbit Adipose Derived Stem Cells in Fibrin: A Pre-clinical Model
使用纤维蛋白中的兔脂肪干细胞进行喉组织工程:临床前模型
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Travis L. Shiba;J. Hardy;Jennifer L Long - 通讯作者:
Jennifer L Long
Scaffold for laryngeal reconstruction
喉重建支架
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Jennifer L Long - 通讯作者:
Jennifer L Long
Transnasal Esophagoscopy and the Diagnosis of a Mediastinal Foregut Duplication Cyst
经鼻食管镜检查及纵隔前肠重复囊肿的诊断
- DOI:
10.1177/014556131309200805 - 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Amarbir S. Gill;Jennifer L Long - 通讯作者:
Jennifer L Long
Jennifer L Long的其他文献
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{{ truncateString('Jennifer L Long', 18)}}的其他基金
Enabling careers as surgeon-scientists in otolaryngology-head and neck surgery
促进耳鼻喉头颈外科外科医生科学家的职业生涯
- 批准号:
10668403 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Tissue engineering to regenerate functional vocal fold after scarring or tissue loss
组织工程可在疤痕或组织损失后再生功能性声带
- 批准号:
10218135 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Tissue engineering to regenerate functional vocal fold after scarring or tissue loss
组织工程可在疤痕或组织损失后再生功能性声带
- 批准号:
10454183 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Tissue engineering to regenerate functional vocal fold after scarring or tissue loss
组织工程可在疤痕或组织损失后再生功能性声带
- 批准号:
9982294 - 财政年份:2018
- 资助金额:
-- - 项目类别:
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