Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.

项目摘要 心力衰竭伴保留射血分数(HFpEF)是最常见的心力衰竭形式，与 发病率和死亡率高，患病率增加，预后恶化。HFpEF的生活质量 与射血分数降低的心力衰竭一样差或更糟，主要是因为剧烈的运动 不宽容；这种萌芽状态的主要表现。根据资金公告PAR-20-078 它支持使用现有的人类数据集进行重点明确的二次分析，以调查新的 有可能对NHLBI相关生物医学或生物行为研究产生重大影响的方法， 我们将利用现有的心脏磁共振图像数据库，在一组表型良好的 HFpEF患者与年龄、性别匹配的健康对照组的综合鉴定和特征 HFpEF的病理生理机制。我们将使用一种新的单图像多端点分析 比较四腔心功能(右房、右室、左房、左房)的最简单方法 在HFpEF和健康对照组之间，测量主动脉扩张性和心包脂肪负荷并确定 他们的独立和联合与运动耐量和生活质量有关。

Project Summary Heart Failure with Preserved Ejection Fraction (HFpEF) is the most common form of heart failure, is associated with high morbidity and mortality, with increasing prevalence and worsening prognosis. Quality-of-life in HFpEF is as poor or worse than heart failure with reduced ejection fraction, in large part because of severe exercise intolerance; the primary manifestation of this bourgeoning condition. Per funding announcement PAR-20-078 which supports the use of existing human datasets for well-focused secondary analyses to investigate new methods that have the potential for significant impact on NHLBI relevant biomedical or biobehavioral research, we will leverage an existing database of cardiac magnetic resonance images in a cohort of well-phenotyped patients with HFpEF and age- and sex-matched healthy controls to comprehensively identify and characterize pathophysiologic mechanisms driving HFpEF. We will use a novel Single Image Multi-endPoint anaLysis (SIMPL) approach to compare four chamber cardiac function (right atrium, right ventricle, left atrium, left ventricle), aortic distensibility, and pericardial fat burden between HFpEF and healthy controls, and to determine their independent and combined association with exercise tolerance and quality of life.