Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging

七台特斯拉临床前 MRI/S 扫描仪，用于结构、功能和分子成像

• 批准号: 10175370
• 负责人: Joanna R Long
• 金额: $ 200万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175370
• 关键词: Basic Science; Biomedical Research; Brain; Clinical Research; Cognition Disorders; Development; Disease; Disease model; Duchenne muscular dystrophy; Equilibrium; Florida; Fostering; Functional Imaging; Funding; Human; Institutes; Laboratories; Magnetic Resonance Imaging; Measurement; Minor; Muscle; Positioning Attribute; Protocols documentation; Research; Research Project Grants; Research Support; Resolution; Spectrum Analysis; Structure; Study models; System; Technology; Translational Research; United States National Institutes of Health; Universities; Work; aged; anatomic imaging; cognitive function; heart imaging; imaging approach; improved; in vivo; instrument; magnetic field; metabolic imaging; metabolomics; molecular imaging; neuroimaging; pre-clinical; programs; spectroscopic imaging

The University of Florida (UF) requests funds to purchase a state-of-the-art preclinical 7 Tesla (7 T) magnetic resonance imaging and spectroscopy (MRI/S) system to support biomedical research using advanced anatomic, functional, spectroscopic, metabolic and physiologic imaging approaches. The proposed instrument will provide much needed advanced technologies that are not available on our current aged and technologically-obsolete preclinical 4.7 T MRI/S system located in the Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility at UF. The AMRIS Facility is uniquely positioned as part of both the National High Magnetic Field Laboratory and the McKnight Brain Institute. It supports MRI and in vivo spectroscopy development and applications at ultra-high fields (led by Marcelo Febo, Tom Mareci, Matt Merritt, and Glenn Walter) as well as translational research in neuroimaging of cognitive function and disease (including the preclinical work of Jose Abisambra, Sara Burke, Eduardo Candelario-Jalil, Tom Foster, Todd Golde, Catherine Kaczorowski, Duane Mitchell, Barry Setlow, Malu Tansey, Shahab Vadhat, David Vaillancourt, Kevin Wang, and Lakiesha Williams), muscular and cardiac imaging associated with Duchenne muscular dystrophy (including the preclinical work of Sean Forbes, Lee Sweeney, and Glenn Walter), and in vivo measurements of metabolism and its impacts in disease (Charlie Khemtong and Matt Merritt). This instrument will provide an important bridge between our clinical research program at 3 T and our high-field basic research program utilizing our existing 11.1 T/40 cm and 17.6 T/8.9 cm MRI/S systems. Our existing preclinical systems (the 11.1 T and aged 4.7 T systems) support 21 NIH-funded research projects, with 17 of them (from 11 major users and four minor users) able to maximally benefit from the acquisition of the proposed 7 T system and four of them (minor users) taking advantage of field-dependent measurement capabilities. The proposed 7 T MRI/S system will (i) offer optimal user accessibility for non-expert users routinely using MRI/S protocols in their research, (ii) allow maximal research support by enabling us to balance the usage and configurations of our MRI/S systems, (iii) significantly improve sensitivity and resolution compared to our existing 4.7 T system, and (iv) provide an optimal field for translational research integrating preclinical disease model studies with clinical studies in humans.

佛罗里达大学（UF）要求资金购买最先进的临床前7特斯拉（7 t）磁 共振成像和光谱（MRI/S）系统，用于使用先进的生物医学研究 解剖，功能，光谱，代谢和生理成像方法。提议 仪器将提供急需的高级技术 高级磁共振中的技术观察到临床前4.7 T MRI/S系统 UF的成像和光谱学（AMRIS）设施。 AMRIS设施被唯一地定位为两者的一部分 国家高磁场实验室和麦克奈特脑研究所。它支持MRI和体内 超高场的光谱开发和应用（由Marcelo Febo，Tom Mareci，Matt领导 Merritt和Glenn Walter）以及认知功能和疾病神经影像学的转化研究 （包括Jose Abisambra，Sara Burke，Eduardo Candelario-Jalil，Tom Foster，Todd的临床前工作 Golde，Catherine Kaczorowski，Duane Mitchell，Barry Setlow，Malu Tansey，Shahab Vadhat，David Vaillancourt，Kevin Wang和Lakiesha Williams），与Duchenne相关的肌肉和心脏成像 肌肉营养不良（包括Sean Forbes，Lee Sweeney和Glenn Walter的临床前工作）以及 代谢及其对疾病的影响（Charlie Khemtong和Matt Merritt）的体内测量。这 仪器将在3 T时提供我们的临床研究计划与我们的高场面之间的重要桥梁 利用我们现有的11.1 T/40厘米和17.6 T/8.9厘米MRI/S系统的基础研究计划。我们的现有 临床前系统（11.1 T和4.7 T系统）支持21个由NIH资助的研究项目，有17个 其中（来自11位主要用户和四个未成年人），能够从获得 提出的7 T系统，其中四个（次要用户）利用了依赖现场的测量 功能。提议的7 T MRI/S系统（i）将为非专家用户提供最佳的用户可访问性 （ii）通常使用MRI/S协议通常使用MRI/S协议，使我们能够使我们能够实现最大的研究支持 平衡MRI/S系统的使用和配置，（iii）显着提高灵敏度和 与我们现有的4.7 T系统相比，分辨率和（iv）为转化研究提供了一个最佳领域 将临床前疾病模型研究与人类的临床研究相结合。