Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging

佛罗里达大学(UF)申请资金购买最先进的临床前7特斯拉(7 T)磁铁 磁共振成像和光谱学(磁共振/S)系统，使用先进的 解剖、功能、光谱、代谢和生理成像方法。建议数 仪器将提供急需的先进技术，这些技术在我们当前的老龄化和 技术陈旧的4.7T临床前磁共振/S系统位于高级磁共振 UF的成像和光谱(AMRIS)设施。AMRIS设施的独特定位是两者的一部分 国家强磁场实验室和麦克奈特脑研究所。它支持核磁共振和活体实验 超高场光谱学的发展和应用(由Marcelo Febo，Tom Mareci，Matt领导 Merritt和Glenn Walter)，以及认知功能和疾病的神经成像的翻译研究 (包括Jose Abisambra、Sara Burke、Eduardo Candelario-Jalil、Tom Foster、Todd的临床前工作 戈尔德，凯瑟琳·卡佐罗夫斯基，杜安·米切尔，巴里·塞特洛，马鲁·坦西，沙哈布·瓦达特，大卫 Vaillancourt，Kevin Wang和LaKiesha Williams)，与杜兴相关的肌肉和心脏成像 肌营养不良(包括肖恩·福布斯、李·斯威尼和格伦·沃尔特的临床前工作)，以及在 新陈代谢的活体测量及其对疾病的影响(Charlie Khemtong和Matt Merritt)。这 仪器将在我们的3T临床研究计划和我们的高场强之间提供重要的桥梁 基础研究计划利用我们现有的11.1T/40厘米和17.6T/8.9厘米磁共振/S系统。我们现有的 临床前系统(11.1T和4.7T系统)支持NIH资助的21个研究项目，其中17个 他们(来自11个主要用户和4个次要用户)能够从收购 提出了7T系统，其中四个(小用户)利用了场相关测量 能力。拟议的7T核磁共振/S系统将(I)为非专家用户提供最佳的用户访问权限 在他们的研究中常规使用核磁共振/S方案，(Ii)通过使我们能够 平衡我们核磁共振/S系统的使用和配置，(Iii)显著提高灵敏度和 分辨率与我们现有的4.7T系统相比，以及(Iv)为翻译研究提供了一个最佳领域 将临床前疾病模型研究与人类临床研究相结合。

The University of Florida (UF) requests funds to purchase a state-of-the-art preclinical 7 Tesla (7 T) magnetic resonance imaging and spectroscopy (MRI/S) system to support biomedical research using advanced anatomic, functional, spectroscopic, metabolic and physiologic imaging approaches. The proposed instrument will provide much needed advanced technologies that are not available on our current aged and technologically-obsolete preclinical 4.7 T MRI/S system located in the Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility at UF. The AMRIS Facility is uniquely positioned as part of both the National High Magnetic Field Laboratory and the McKnight Brain Institute. It supports MRI and in vivo spectroscopy development and applications at ultra-high fields (led by Marcelo Febo, Tom Mareci, Matt Merritt, and Glenn Walter) as well as translational research in neuroimaging of cognitive function and disease (including the preclinical work of Jose Abisambra, Sara Burke, Eduardo Candelario-Jalil, Tom Foster, Todd Golde, Catherine Kaczorowski, Duane Mitchell, Barry Setlow, Malu Tansey, Shahab Vadhat, David Vaillancourt, Kevin Wang, and Lakiesha Williams), muscular and cardiac imaging associated with Duchenne muscular dystrophy (including the preclinical work of Sean Forbes, Lee Sweeney, and Glenn Walter), and in vivo measurements of metabolism and its impacts in disease (Charlie Khemtong and Matt Merritt). This instrument will provide an important bridge between our clinical research program at 3 T and our high-field basic research program utilizing our existing 11.1 T/40 cm and 17.6 T/8.9 cm MRI/S systems. Our existing preclinical systems (the 11.1 T and aged 4.7 T systems) support 21 NIH-funded research projects, with 17 of them (from 11 major users and four minor users) able to maximally benefit from the acquisition of the proposed 7 T system and four of them (minor users) taking advantage of field-dependent measurement capabilities. The proposed 7 T MRI/S system will (i) offer optimal user accessibility for non-expert users routinely using MRI/S protocols in their research, (ii) allow maximal research support by enabling us to balance the usage and configurations of our MRI/S systems, (iii) significantly improve sensitivity and resolution compared to our existing 4.7 T system, and (iv) provide an optimal field for translational research integrating preclinical disease model studies with clinical studies in humans.