Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging

七台特斯拉临床前 MRI/S 扫描仪，用于结构、功能和分子成像

• 批准号: 10175370
• 负责人: Joanna R Long
• 金额: $ 200万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175370
• 关键词: Basic Science; Biomedical Research; Brain; Clinical Research; Cognition Disorders; Development; Disease; Disease model; Duchenne muscular dystrophy; Equilibrium; Florida; Fostering; Functional Imaging; Funding; Human; Institutes; Laboratories; Magnetic Resonance Imaging; Measurement; Minor; Muscle; Positioning Attribute; Protocols documentation; Research; Research Project Grants; Research Support; Resolution; Spectrum Analysis; Structure; Study models; System; Technology; Translational Research; United States National Institutes of Health; Universities; Work; aged; anatomic imaging; cognitive function; heart imaging; imaging approach; improved; in vivo; instrument; magnetic field; metabolic imaging; metabolomics; molecular imaging; neuroimaging; pre-clinical; programs; spectroscopic imaging

The University of Florida (UF) requests funds to purchase a state-of-the-art preclinical 7 Tesla (7 T) magnetic resonance imaging and spectroscopy (MRI/S) system to support biomedical research using advanced anatomic, functional, spectroscopic, metabolic and physiologic imaging approaches. The proposed instrument will provide much needed advanced technologies that are not available on our current aged and technologically-obsolete preclinical 4.7 T MRI/S system located in the Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility at UF. The AMRIS Facility is uniquely positioned as part of both the National High Magnetic Field Laboratory and the McKnight Brain Institute. It supports MRI and in vivo spectroscopy development and applications at ultra-high fields (led by Marcelo Febo, Tom Mareci, Matt Merritt, and Glenn Walter) as well as translational research in neuroimaging of cognitive function and disease (including the preclinical work of Jose Abisambra, Sara Burke, Eduardo Candelario-Jalil, Tom Foster, Todd Golde, Catherine Kaczorowski, Duane Mitchell, Barry Setlow, Malu Tansey, Shahab Vadhat, David Vaillancourt, Kevin Wang, and Lakiesha Williams), muscular and cardiac imaging associated with Duchenne muscular dystrophy (including the preclinical work of Sean Forbes, Lee Sweeney, and Glenn Walter), and in vivo measurements of metabolism and its impacts in disease (Charlie Khemtong and Matt Merritt). This instrument will provide an important bridge between our clinical research program at 3 T and our high-field basic research program utilizing our existing 11.1 T/40 cm and 17.6 T/8.9 cm MRI/S systems. Our existing preclinical systems (the 11.1 T and aged 4.7 T systems) support 21 NIH-funded research projects, with 17 of them (from 11 major users and four minor users) able to maximally benefit from the acquisition of the proposed 7 T system and four of them (minor users) taking advantage of field-dependent measurement capabilities. The proposed 7 T MRI/S system will (i) offer optimal user accessibility for non-expert users routinely using MRI/S protocols in their research, (ii) allow maximal research support by enabling us to balance the usage and configurations of our MRI/S systems, (iii) significantly improve sensitivity and resolution compared to our existing 4.7 T system, and (iv) provide an optimal field for translational research integrating preclinical disease model studies with clinical studies in humans.

佛罗里达大学（UF）申请资金购买最先进的临床前7特斯拉（7 T）磁 磁共振成像和光谱（MRI/S）系统，以支持生物医学研究，使用先进的 解剖、功能、光谱、代谢和生理成像方法。拟议 仪器将提供急需的先进技术，而这些技术在我们目前的老年人和 位于高级磁共振中的技术过时的临床前4.7 T MRI/S系统 成像和光谱（AMRIS）设施在UF。AMRIS设施是唯一定位的一部分， 国家高磁场实验室和麦克奈特脑研究所。它支持MRI和体内 光谱学的发展和应用在超高领域（由Marcelo Febo，Tom Mareci，Matt Merritt和Glenn Walter）以及认知功能和疾病的神经影像学转化研究 （包括Jose Abisambra、Sara Burke、Eduardo Candelario-Jalil、Tom Foster、托德 Golde，Catherine Kaczorowski，Duane Mitchell，巴里Setlow，Malu Tansey，Shahab Vadhat，大卫 Vaillancourt，Kevin Wang，and Lakiesha威廉姆斯），与杜兴氏病相关的肌肉和心脏成像 肌营养不良症（包括Sean福布斯、Lee Sweeney和Glenn Walter的临床前工作）， 代谢及其对疾病影响的体内测量（Charlie Khemtong和Matt Merritt）。这 仪器将在我们的3 T临床研究计划和我们的高场之间提供重要的桥梁 利用我们现有的11.1 T/40 cm和17.6 T/8.9 cm MRI/S系统的基础研究计划。我们现有 临床前系统（11.1 T和老化的4.7 T系统）支持21个NIH资助的研究项目，其中17个 其中（11个主要用户和4个次要用户）能够最大限度地受益于 提出了7 T系统，其中4个（小用户）利用了场相关测量 能力的拟议的7 T MRI/S系统将（i）为非专家用户提供最佳的用户可访问性 在他们的研究中常规使用MRI/S协议，（ii）通过使我们能够 平衡我们的MRI/S系统的使用和配置，（iii）显著提高灵敏度， 分辨率相比，我们现有的4.7 T系统，和（iv）提供了一个最佳领域的转化研究 将临床前疾病模型研究与人类临床研究相结合。