Driving Biomedical Projects

推动生物医学项目

• 批准号: 10217181
• 负责人: Joanna R Long
• 金额: $ 12.67万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217181
• 关键词: Address; Area; Automobile Driving; Awareness; Beds; Biological; Biomedical Research; Biomolecular Nuclear Magnetic Resonance; Cell Nucleus; Collection; Communities; Data Analyses; Data Collection; Detection; Development; Disease; Ensure; Evaluation; Experimental Designs; Feedback; Fostering; Home; Hybrids; Individual; Institution; Isotopes; Membrane Proteins; Nuclear; Performance; Physiologic pulse; Preparation; Proteins; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Sampling; Series; Structure; Techniques; Technology; Testing; Training; Translating; United States National Institutes of Health; computerized data processing; design; enzyme mechanism; experimental study; grasp; high sensitivity probe; improved; insight; instrumentation; interest; magnetic field; metabolomics; next generation; programs; recruit; technology development

Driving Biomedical Projects Project Summary/Abstract We have identified thirteen driving biomedical projects for the National Resource for Advanced NMR Technology BTRR. These projects are led by PIs who are leaders in NMR technology development in their own regard and who are at the forefront of new and exciting biomedical research applications. This ensures that they will actively participate in technology development, experimental design, and developing data collection and analysis strategies. They will also provide immediate and insightful feedback on technology performance. For the DBPs we have three specific aims: 1) Demonstrate capabilities and provide evaluation for ultrasensitive cryoprobe technologies developed by TR&D1; 2) Demonstrate capabilities and provide evaluation for dynamic nuclear polarization (DNP) technologies developed by TR&D2; and 3) Demonstrate capabilities and provide evaluation for series connected hybrid (SCH) magnet technologies developed by TR&D3. Many of the DBPs will be actively involved with two or even three of the TR&D projects. This wide ranging engagement fosters the proliferation of ideas and techniques between the various projects. The DBPs are characterized by research that is at the forefront of the NMR field in developing new techniques and applying them to extremely challenging biomedical research problems. Many of them have the most advanced commercial NMR technology available at their home institutions, and are pushing the boundaries of sensitivity and resolution with creative approaches to NMR pulse sequences, sample preparation strategies, and data processing and analysis. They are all keenly aware of the need for improved capabilities, particularly through implementing higher magnetic fields, developing the highest sensitivity probes possible, and pursuing dynamic nuclear polarization as an orthogonal strategy to improve sensitivity. We have long standing relationships with many of the DBP contributors, as collaborators and users of the NHMFL facilities ensuring lively and productive dialogue. We view the collection of DBPs we have assembled as the best suited to push devel- opment of the TR&D's with biomedical research programs in five primary areas of interest to the NIH: intrinsi- cally disordered proteins, membrane proteins, protein assemblies, enzyme mechanisms and metabolomics. Collectively, the technology developments proposed through the TR&Ds are paramount to advancing the sensitivity and resolution needed to address vanguard biomedical questions posed by the DBPs, and through the guidance of the DBPs we will pioneer the next step in NMR technology.

推动生物医学项目 项目概要/摘要 我们已为国家先进核磁共振资源确定了 13 个驱动生物医学项目 技术BTRR。这些项目由 PI 领导，他们是各自领域 NMR 技术开发的领导者。 自己的观点以及谁处于新的、令人兴奋的生物医学研究应用的最前沿。这确保了 他们将积极参与技术开发、实验设计和开发数据 收集和分析策略。他们还将提供有关技术的即时和富有洞察力的反馈 表现。对于 DBP，我们有三个具体目标：1) 展示能力并提供评估 TR&D1 开发的超灵敏冷冻探针技术； 2）展示能力并提供 对TR&D2开发的动态核极化（DNP）技术的评估； 3) 展示 能力并为串联混合（SCH）磁体技术提供评估 技术与发展3。许多 DBP 将积极参与两个甚至三个 TR&D 项目。这个宽 广泛的参与促进了不同项目之间想法和技术的扩散。 DBP 其特点是在开发新技术方面处于 NMR 领域前沿的研究 将它们应用于极具挑战性的生物医学研究问题。其中许多拥有最先进的 商业 NMR 技术可在其所在机构使用，并且正在突破灵敏度的界限 通过 NMR 脉冲序列、样品制备策略和数据的创新方法来解决问题 处理和分析。他们都敏锐地意识到提高能力的必要性，特别是通过 实现更高的磁场，开发尽可能高灵敏度的探头，并追求动态 核极化作为提高灵敏度的正交策略。我们与以下公司有着长期的合作关系 作为 NHMFL 设施的合作者和用户，许多 DBP 贡献者确保了活跃和 富有成效的对话。我们认为我们收集的 DBP 集合是最适合推动开发的 NIH 感兴趣的五个主要领域的 TR&D 与生物医学研究计划的结合： 特别是无序蛋白质、膜蛋白、蛋白质组装、酶机制和代谢组学。 总的来说，通过 TR&D 提出的技术开发对于推进 解决 DBP 提出的前沿生物医学问题所需的敏感性和分辨率，并通过 在 DBP 的指导下，我们将引领 NMR 技术的下一步。