Training Program in Cardiovascular Applied Research and Entrepreneurship

项目摘要 我们要求更新我们的培训计划：心血管应用研究和创业 (关爱)。创造可成功商业化和部署的新心血管技术 在临床环境中依赖于一系列的技能和知识，包括工程学、心血管 科学和企业家精神。当前培训环境的结构不适合在 单个人，因此形成了高度专业化的专业人员团队。不可避免的是，阻碍 学科和团队成员之间存在沟通，从长远来看，这不可避免地造成效率低下 从创意构思到成功商业化是一个艰辛的过程。我们提出了一项新的 培训转化型心血管研究人员的范例，包括有效获取基地 具备三个主要学科(工程学、心血管科学和创业学)的技能(或“流利性”)。 这是CARE项目，大多数学员将攻读生物医学博士学位 工程学。我们请求为四名博士前实习生提供支持。爱德华兹生命科学中心 先进心血管技术和UCI研究生部将支持另外两名学生 该计划在任何时候总共有六个。这些受训人员通过三个现有的 包括医学科学家培训计划(MSTP)在内的路径(或“馈线计划”) 计算生物学(MCB)“门户”计划，或生物医学工程的常规博士计划。 获得流利程度的机制从传统的说教课程、原创研究到博士学位 学位，培训俱乐部，指导，创建学习档案，以及参与UCI的年度商业计划 竞争。我们还将为爱德华兹的实习生创建一个家，并利用爱德华兹的资源 加州大学洛杉矶分校先进心血管技术生命科学中心。该计划正在创建一个新的 培养能够更有效地开发可翻译技术的心血管研究人员，以及 更有效地与专业企业家和临床医生沟通。我们成功发射了四枚 几年前，已经或正在培训13名学生。T32支持四个 这些学生在二年级和三年级攻读博士学位。由于这是我们的第一次续签，我们只有一次 到目前为止，学生们已经毕业了。这群学生已经发表了25篇论文和两篇论文 (独立)在校园商业计划大赛中荣获最高奖项。我们相信我们的关怀 该计划对未来的成功具有很高的潜力。

Project Summary We are requesting renewal of our Training Program: Cardiovascular Applied Research and Entrepreneurship (CARE). The creation of new cardiovascular technology that can be successfully commercialized and deployed in the clinical environment relies on an array of skills and knowledge including engineering, cardiovascular science, and entrepreneurship. Current training environments are not structured to cultivate these skills in a single individual, and so teams of highly specialized professionals are formed. Inevitably, barriers to communication exist between the disciplines and team members that invariably create inefficiencies in the long and arduous process from idea conception to successful commercialization. We have proposed a new paradigm for training translational cardiovascular researchers that includes the efficient acquisition of a base skill set (or “fluency”) in three major disciplines (engineering, cardiovascular science, and entrepreneurship). This is the CARE program, and the majority of trainees will pursue the doctoral degree in biomedical engineering. We are requesting support for four pre-doctoral trainees. The Edwards Lifesciences Center for Advanced Cardiovascular Technology along with UCI Graduate Division will support a further two students in the program for a total of six at any one time. These trainees enter the program through three existing pathways (or “feeder programs”) that include the medical scientist training program (MSTP), a mathematical computational biology (MCB) “gateway” program, or the regular doctoral program in biomedical engineering. Mechanisms to acquire fluency range from traditional didactic courses, original research leading to the doctoral degree, training clubs, mentoring, creating a learning portfolio, and participation in UCI's annual business plan competition. We will also create a home for the trainees in, and leverage resources from, The Edwards Lifesciences Center for Advanced Cardiovascular Technology here at UCI. The program is creating a new breed of cardiovascular researchers who can develop translatable technology more efficiently, and communicate more effectively with professional entrepreneurs and clinicians. We launched successfully four years ago and have already trained, or are in the process of training, 13 students. The T32 supports four of these students in years two and three of their Ph.D. studies. As this is our first renewal, only one of our students has so far graduated. This cohort of students has already published 25 papers and two (independently) have won top awards in the campus-wide business plan competition. We believe the CARE program has a high potential for future successes.