Training Program in Cardiovascular Applied Research and Entrepreneurship

项目摘要 我们要求更新我们的培训计划：心血管应用研究和创业 （CARE）.创造可以成功商业化和部署的新心血管技术 在临床环境中依赖于一系列的技能和知识，包括工程，心血管， 科学和企业家精神。目前的培训环境并不是为了培养这些技能， 因此，形成了高度专业化的专业团队。不可避免地， 在规程和团队成员之间存在的沟通， 从概念构思到成功商业化的艰难过程。我们提出了一个新的 培训转化型心血管研究人员的范例，包括有效获取基础知识， 在三个主要学科（工程学、心血管科学和企业家精神）的技能组合（或“流利性”）。 这就是CARE计划，大多数学员将攻读生物医学博士学位 工程.我们正在申请对四名博士前实习生的支持。爱德华生命科学中心 先进的心血管技术沿着UCI研究生部将支持另外两名学生， 在任何时候都有六个程序。这些受训人员通过现有的三个项目进入该项目。 途径（或“馈线计划”），包括医学科学家培训计划（MSTP），数学 计算生物学（MCB）的“网关”计划，或在生物医学工程的常规博士课程。 从传统的教学课程、原创性研究到博士研究， 学位，培训俱乐部，指导，创建学习组合，并参与UCI的年度业务计划 竞争我们还将为学员创造一个家，并利用爱德华兹的资源 生命科学中心先进的心血管技术在这里UCI。该计划正在创建一个新的 一批心血管研究人员，他们可以更有效地开发可翻译的技术， 与专业企业家和临床医生进行更有效的沟通。我们成功地发射了四个 目前，已有或正在培训13名学生。T32支持四个 这些学生在他们的博士学位的第二年和第三年。问题研究由于这是我们第一次续约， 到目前为止，学生已经毕业。这批学生已经发表了25篇论文， （独立）在校园范围的商业计划竞争中获得最高奖项。我们相信， 该计划在未来取得成功的潜力很大。

Project Summary We are requesting renewal of our Training Program: Cardiovascular Applied Research and Entrepreneurship (CARE). The creation of new cardiovascular technology that can be successfully commercialized and deployed in the clinical environment relies on an array of skills and knowledge including engineering, cardiovascular science, and entrepreneurship. Current training environments are not structured to cultivate these skills in a single individual, and so teams of highly specialized professionals are formed. Inevitably, barriers to communication exist between the disciplines and team members that invariably create inefficiencies in the long and arduous process from idea conception to successful commercialization. We have proposed a new paradigm for training translational cardiovascular researchers that includes the efficient acquisition of a base skill set (or “fluency”) in three major disciplines (engineering, cardiovascular science, and entrepreneurship). This is the CARE program, and the majority of trainees will pursue the doctoral degree in biomedical engineering. We are requesting support for four pre-doctoral trainees. The Edwards Lifesciences Center for Advanced Cardiovascular Technology along with UCI Graduate Division will support a further two students in the program for a total of six at any one time. These trainees enter the program through three existing pathways (or “feeder programs”) that include the medical scientist training program (MSTP), a mathematical computational biology (MCB) “gateway” program, or the regular doctoral program in biomedical engineering. Mechanisms to acquire fluency range from traditional didactic courses, original research leading to the doctoral degree, training clubs, mentoring, creating a learning portfolio, and participation in UCI's annual business plan competition. We will also create a home for the trainees in, and leverage resources from, The Edwards Lifesciences Center for Advanced Cardiovascular Technology here at UCI. The program is creating a new breed of cardiovascular researchers who can develop translatable technology more efficiently, and communicate more effectively with professional entrepreneurs and clinicians. We launched successfully four years ago and have already trained, or are in the process of training, 13 students. The T32 supports four of these students in years two and three of their Ph.D. studies. As this is our first renewal, only one of our students has so far graduated. This cohort of students has already published 25 papers and two (independently) have won top awards in the campus-wide business plan competition. We believe the CARE program has a high potential for future successes.