Supplement to Promote Diversity in the Research Workforce

促进研究人员多样性的补充

基本信息

  • 批准号:
    10177684
  • 负责人:
  • 金额:
    $ 6.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-21 至 2021-08-18
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract (parent grant) Early exposures in critical developmental windows around fertilization, implantation, and during pregnancy can have long-term impact on health, development, and disease in children. A comprehensive assessment of early exposures requires a multidimensional assessment of the exposome, including community-level environmental factors (including air pollution), chemical exposures (including endocrine disruptors), the microbiome (including commensals and infectious agents with associated immune responses), and the genome and its responses to the environment (including the inherited epigenome, genomic expression, and the proteome). We are currently re-enrolling a pediatric cohort from two birth cohorts enrolled peri- conceptionally/prenatally, 1) the Utah participants in the National Children’s Study, and 2) participants in the Home Observation of Peri-conceptional Exposures (HOPE) study, into the Early Life Exposures and Child Trajectories (ELECT) cohort. We are also enrolling biological parents and up to one biological sibling child. In the UG3 phase (the first two years), we focus on completing re-enrollment of the entire cohort, and also on innovative methods for assessment of a spectrum of known and emerging exposures during the key early windows of the peri-conceptional time and early pregnancy. Exposures we assess will include the microbiome, medications, infections, pan-viral antibody assessment, air pollutants (especially particulate pollution (PM2.5), also nitrogen oxides and ozone), endocrine disrupting chemicals (particularly bisphenol-A (BPA) and phthalates), and hypomineralization of dental enamel as a marker for early endocrine disrupting exposure. We will also conduct a preliminary assessment of some health impacts. In UH3 phase, we will focus on the association of these exposures with subsequent outcomes in two focus areas: growth (including insulin resistance and childhood obesity) and respiratory health (including respiratory infections and asthma). We will work completely collaboratively with the ECHO national synthetic cohort to integrate UCP-ELECT into that cohort. We will contribute to the design of the core measures for the synthetic ECHO cohort and implement these within UCP-ELECT. Taken together, this proposal focuses throughout both UG3 and UH3 on novel assessments for exposures that can be translated to other settings of the ECHO synthetic cohort in a feasible and cost-effective manner. We are focused particularly on assessments that can be applied retrospectively in other cohorts to assess very early exposures (peri-conception and early pregnancy). Thus, we will contribute to the ECHO cohort 1) a population-based, pediatric cohort (950 children from 500 families) with extant and new early biospecimens and assessments, and 2) scientific validation of critical multidimensional exposome measurements from preconception through gestation and early childhood. These methods will then be available to assess children across the entire ECHO synthetic cohort to obtain a window on exposures prior to and during gestation, and to assess their impact on the incidence of asthma, obesity, and other outcomes.
项目摘要/摘要(父母补助金) 受精、着床前后和妊娠期间关键发育窗口的早期暴露 可能对儿童的健康、发育和疾病产生长期影响。全面评估 早期暴露需要对问题进行多方面的评估,包括社区一级的评估。 环境因素(包括空气污染)、化学品接触(包括内分泌干扰物)、 微生物组(包括具有相关免疫应答的微生物和感染因子),以及 基因组及其对环境的反应(包括遗传表观基因组,基因组表达, 蛋白质组)。我们目前正在从两个出生队列中重新招募一个儿科队列, 在概念上/产前,1)犹他州的参与者在全国儿童研究,和2)参与者在 家庭观察围概念暴露(HOPE)研究,进入早期生活暴露和儿童 轨迹(ELECT)队列。我们还招募了亲生父母和最多一个亲生兄弟姐妹。在 在UG 3阶段(前两年),我们专注于完成整个队列的重新入组, 评估关键早期阶段已知和新出现的各种暴露的创新方法 围受孕期时间窗和早孕期。我们评估的暴露将包括微生物组, 药物、感染、泛病毒抗体评估、空气污染物(特别是颗粒污染(PM2.5)), 还有氮氧化物和臭氧),内分泌干扰化学品(特别是双酚A(BPA)和 邻苯二甲酸酯),以及牙釉质的矿化不足作为早期内分泌干扰物暴露的标志。我们 还将对一些健康影响进行初步评估。在UH 3阶段,我们将重点关注 这些暴露与两个重点领域的后续结果的关联:生长(包括胰岛素) 抵抗力和儿童肥胖)和呼吸系统健康(包括呼吸道感染和哮喘)。我们将 与ECHO国家合成队列完全合作,将UCP-ELECT整合到 队列。我们将为合成ECHO队列的核心措施的设计做出贡献, 在UCP-ELECT中。综上所述,该提案在整个UG 3和UH 3中都侧重于新颖性。 在可行的环境中,可以将暴露评估转化为ECHO合成队列的其他环境 成本效益的方式。我们特别关注可追溯应用于以下方面的评估: 评估极早期暴露(围受孕期和妊娠早期)的其他队列。因此,我们将作出贡献 ECHO队列1)一个基于人群的儿科队列(来自500个家庭的950名儿童), 新的早期生物标本和评估,以及2)关键多维问题的科学验证 从孕前到怀孕和幼儿期的测量。这些方法将 可用于评估整个ECHO合成队列中的儿童,以在 和妊娠期间,并评估其对哮喘,肥胖和其他结果的发病率的影响。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Christina Porucznik其他文献

Christina Porucznik的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Christina Porucznik', 18)}}的其他基金

Utah Children's Project
犹他州儿童项目
  • 批准号:
    10744930
  • 财政年份:
    2016
  • 资助金额:
    $ 6.12万
  • 项目类别:
Peri-Conceptional Biomonitoring
围孕期生物监测
  • 批准号:
    8848379
  • 财政年份:
    2011
  • 资助金额:
    $ 6.12万
  • 项目类别:
Peri-Conceptional Biomonitoring
围孕期生物监测
  • 批准号:
    8320058
  • 财政年份:
    2011
  • 资助金额:
    $ 6.12万
  • 项目类别:
Peri-Conceptional Biomonitoring
围孕期生物监测
  • 批准号:
    8668059
  • 财政年份:
    2011
  • 资助金额:
    $ 6.12万
  • 项目类别:
Peri-Conceptional Biomonitoring
围孕期生物监测
  • 批准号:
    8182055
  • 财政年份:
    2011
  • 资助金额:
    $ 6.12万
  • 项目类别:
Peri-Conceptional Biomonitoring
围孕期生物监测
  • 批准号:
    8462977
  • 财政年份:
    2011
  • 资助金额:
    $ 6.12万
  • 项目类别:

相似海外基金

Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study
青少年家庭经历中成人身体健康和阿尔茨海默氏病及相关痴呆症 (ADRD) 认知风险的前因:一项前瞻性、纵向收养研究
  • 批准号:
    10464655
  • 财政年份:
    2022
  • 资助金额:
    $ 6.12万
  • 项目类别:
Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study
青少年家庭经历中成人身体健康和阿尔茨海默氏病及相关痴呆症 (ADRD) 认知风险的前因:一项前瞻性、纵向收养研究
  • 批准号:
    10630366
  • 财政年份:
    2022
  • 资助金额:
    $ 6.12万
  • 项目类别:
Adolescent Primary Care Adoption of Substance Use SBI
青少年初级保健药物使用 SBI
  • 批准号:
    6952450
  • 财政年份:
    2004
  • 资助金额:
    $ 6.12万
  • 项目类别:
Adolescent Primary Care Adoption of Substance Use SBI
青少年初级保健药物使用 SBI
  • 批准号:
    6861561
  • 财政年份:
    2004
  • 资助金额:
    $ 6.12万
  • 项目类别:
Adoption and Implementation of Adolescent EBT State-Wide
全州范围内青少年 EBT 的采用和实施
  • 批准号:
    6741059
  • 财政年份:
    2003
  • 资助金额:
    $ 6.12万
  • 项目类别:
Adoption and Implementation of Adolescent EBT State-Wide
全州范围内青少年 EBT 的采用和实施
  • 批准号:
    6929083
  • 财政年份:
    2003
  • 资助金额:
    $ 6.12万
  • 项目类别:
Adoption and Implementation of Adolescent EBT State-Wide
全州范围内青少年 EBT 的采用和实施
  • 批准号:
    6806541
  • 财政年份:
    2003
  • 资助金额:
    $ 6.12万
  • 项目类别:
LONGITUDINAL ADOPTION STUDY OF ADOLESCENT SUBSTANCE EXPERIMENTATION
青少年物质实验的纵向采用研究
  • 批准号:
    6335012
  • 财政年份:
    2000
  • 资助金额:
    $ 6.12万
  • 项目类别:
LONGITUDINAL ADOPTION STUDY OF ADOLESCENT SUBSTANCE EXPERIMENTATION
青少年物质实验的纵向采用研究
  • 批准号:
    6104174
  • 财政年份:
    1999
  • 资助金额:
    $ 6.12万
  • 项目类别:
LONGITUDINAL ADOPTION STUDY OF ADOLESCENT SUBSTANCE EXPERIMENTATION
青少年物质实验的纵向采用研究
  • 批准号:
    6270052
  • 财政年份:
    1998
  • 资助金额:
    $ 6.12万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了