Utah Children's Project

犹他州儿童项目

• 批准号: 10744930
• 负责人: Christina Porucznik
• 金额: $ 295.61万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744930
• 关键词: Accounting; Address; Air; Air Pollutants; Air Pollution; Area; Asthma; Biological; Birth; Breast Feeding; Bronchiolitis; Characteristics; Chemical Exposure; Child; Child Development; Child Health; Childhood; Collaborations; Communities; Complex; Conceptions; Consent; County; Couples; DNA; Data; Data Collection; Data Element; Demographic Factors; Development; Dimensions; Disease; Endocrine Disruptors; Enrollment; Environment; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Etiology; Family; Fathers; Fertility; Fertilization; Future; Genome; Genomics; Geography; Goals; Health; Hispanic; Home; Housing; Individual; Indoor Air Quality; Inherited; Link; Measurement; Measures; Mediating; Metabolic; Minority Groups; Modeling; Mothers; Native Hawaiian or Other Pacific Islander; Outcome; Ozone; Pacific Islander; Paper; Parents; Participant; Particulate Matter; Pathway interactions; Perinatal; Persons; Phase; Phenols; Planned Pregnancy; Pregnancy; Pregnancy Complications; Pregnant Women; Premature Birth; Process; Proteome; Protocols documentation; Public Health; Publishing; Research; Risk; Sampling; Science; Site; Sodium Chloride; Spontaneous abortion; Time; Underrepresented Minority; Utah; Woman; Work; Writing; air monitoring; cohort; environmental chemical; epigenome; experience; follow-up; hispanic community; implantation; indoor concentrations; infertility treatment; innovation; microbiome; multiple data types; offspring; perinatal outcomes; phthalates; pollutant; pregnant; prenatal; recruit; reproductive outcome; response; sensor; social factors; subfertility; success; time-to-pregnancy; urinary; volatile organic compound

PROJECT SUMMARY / ABSTRACT A comprehensive assessment of early exposures requires a multidimensional assessment of the exposome, including community-level environmental factors (such as air pollution), chemical exposures (such as endocrine disruptors), social factors (cultural and family context), and the genome and its responses to the environment (inherited epigenome, genomic expression, and the proteome). The Utah Children’s Project (UCP) has been the Utah site contributing to the ECHO Cohort consortium for 7 years. The UCP follows the exposure and outcome status of up to 2 children and at least 1 biological parent in 493 family units as well as enrolls couples planning pregnancy and pregnant people. In the UG3 Phase (the first two years), preconception and pregnancy enrollments will continue during the development of the cohort-wide preconception protocol in partnership with the other consortium sites. The UCP will also continue with retention and follow-up of families previously enrolled. Exposure assessment during the preconception and pregnancy periods is a specialized site focus area. In the UH3 Phase, preconception and pregnancy enrollments will continue with particular emphasis on Utah families from underrepresented minority populations (eg, Native Hawaiian or Other Pacific Islander, Hispanic), with a goal of up to 600 new enrollments with implementation of all aspects of the ECHO 3.0 protocol while maintaining a historically high cohort retention. Research questions to be investigated include (1) the relationship between subfertility, maternal metabolic status, fertility treatment, breastfeeding, and asthma in offspring, (2) the relationship between indoor air quality and perinatal outcomes, and (3) longitudinal preconception exposome mixtures and perinatal outcomes. A process-related aim is to re- enroll and retain at least 95% of currently enrolled children throughout the UG3 Phase, and 90% through the UH3 phase while implementing the ECHO 3.0 protocol with high fidelity and response rates.

项目概要/摘要 对早期暴露的全面评估需要对暴露组进行多维评估， 包括社区层面的环境因素（如空气污染）、化学物质暴露（如 内分泌干​​扰物）、社会因素（文化和家庭背景）以及基因组及其对环境的反应 环境（遗传的表观基因组、基因组表达和蛋白质组）。犹他州儿童项目 (UCP) 七年来一直是 ECHO Cohort 联盟的犹他州站点。 UCP 遵循 493 个家庭单位中最多 2 名儿童和至少 1 名亲生父母的暴露和结果状态 招募计划怀孕的夫妇和怀孕的人。在UG3阶段（前两年）， 在整个队列的开发过程中，将继续进行孕前和怀孕登记 与其他联盟网站合作的孕前协议。 UCP 还将继续保留 以及对先前注册的家庭进行跟踪。孕前和怀孕期间的暴露评估 period 是一个专门的站点重点区域。在 UH3 阶段，孕前和怀孕登记将 继续特别重视犹他州来自代表性不足的少数族裔的家庭（例如，原住民 夏威夷人或其他太平洋岛民、西班牙裔），目标是通过实施 ECHO 3.0 协议的所有方面，同时保持历史上较高的队列保留率。研究问题 待研究的内容包括（1）生育力低下、母体代谢状况、生育治疗之间的关系， 母乳喂养和后代哮喘，(2) 室内空气质量和围产期结局之间的关系， (3) 纵向孕前暴露混合物和围产期结局。与流程相关的目标是重新 在整个 UG3 阶段招收并留住至少 95% 的当前招收儿童，并在整个阶段招收并保留 90% UH3 阶段，同时实施具有高保真度和响应率的 ECHO 3.0 协议。

项目成果

Association between peri-conceptional bisphenol A exposure in women and men and time to pregnancy-The HOPE study.

• DOI: 10.1111/ppe.12578
• 发表时间: 2019-08
• 期刊: Paediatric and perinatal epidemiology
• 影响因子: 2.8
• 作者: D. Yeum;Shinyoung Ju;K. Cox;Yue Zhang;J. Stanford;C. Porucznik

Maternal Pre-Pregnancy BMI, Breastfeeding, and Child BMI.

母亲孕前 BMI、母乳喂养和儿童 BMI。

• DOI: 10.1542/peds.2023-061466
• 发表时间: 2024
• 期刊: Pediatrics
• 影响因子: 8
• 作者: Shipp,GayleM;Wosu,AdaezeC;Knapp,EmilyA;Sauder,KatherineA;Dabelea,Dana;Perng,Wei;Zhu,Yeyi;Ferrara,Assiamira;Dunlop,AnneL;Deoni,Sean;Gern,James;Porucznik,Christy;Aris,IzzuddinM;Karagas,MargaretR;Sathyanarayana,Sheela;O'C
• 通讯作者: O'C

Assessment of Psychosocial and Neonatal Risk Factors for Trajectories of Behavioral Dysregulation Among Young Children From 18 to 72 Months of Age.

• DOI: 10.1001/jamanetworkopen.2023.10059
• 发表时间: 2023-04-03
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Hofheimer, Julie A.;McGrath, Monica;Musci, Rashelle;Wu, Guojing;Polk, Sarah;Blackwell, Courtney K.;Stroustrup, Annemarie;Annett, Robert D.;Aschner, Judy;Carter, Brian S.;Check, Jennifer;Conradt, Elisabeth;Croen, Lisa A.;Dunlop, Anne L.;Elliott, Amy J.;Law, Andrew;Leve, Leslie D.;Neiderhiser, Jenae M.;O'Shea, T. Michael;Salisbury, Amy L.;Sathyanarayana, Sheela;Singh, Rachana;Smith, Lynne M.;Aguiar, Andrea;Angal, Jyoti;Carliner, Hannah;McEvoy, Cindy;Ondersma, Steven J.;Lester, Barry
• 通讯作者: Lester, Barry

Compliance with daily, home-based collection of urinary biospecimens in a prospective, preconception cohort.

• DOI: 10.1097/ee9.0000000000000050
• 发表时间: 2019-06-01
• 期刊: Environmental epidemiology (Philadelphia, Pa.)
• 作者: Cox, Kyley J;Stanford, Joseph B;Porucznik, Christina A
• 通讯作者: Porucznik, Christina A

Effectiveness of Self-Collected, Ambient Temperature-Preserved Nasal Swabs Compared to Samples Collected by Trained Staff for Genotyping of Respiratory Viruses by Shotgun RNA Sequencing: Comparative Study.

• DOI: 10.2196/32848
• 发表时间: 2023-11-24
• 期刊: JMIR formative research
• 影响因子: 2.2