Ultrasound System for Transational Research

用于转化研究的超声系统

• 批准号: 10177501
• 负责人: Albert J Sinusas
• 金额: $ 58.97万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2022-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177501
• 关键词: 3-Dimensional; Abdomen; Adult; Applied Research; Biomedical Engineering; Blood Vessels; Cardiac Surgery procedures; Cardiovascular system; Catheters; Complex; DCNU; Echocardiography; Electrophysiology (science); Engineering; Evaluation; Fluoroscopy; Frequencies; Funding; Future; Healthcare; Heart; Hybrids; Image; Intervention; Interventional Ultrasonography; Malignant neoplasm of liver; Minor; Mitral Valve; Multimodal Imaging; Myocardial; Myocardial Ischemia; Organ Transplantation; Pharmaceutical Preparations; Polymers; Positioning Attribute; Positron-Emission Tomography; Procedures; Research; Research Personnel; Resources; Roentgen Rays; Schools; Services; Slice; System; Time; Training; Transesophageal Echocardiography; Translational Research; Ultrasonography; United States National Institutes of Health; aortic valve; arm; base; congenital anomaly; congenital heart disorder; end of life; gene therapy; image guided; image guided intervention; imaging probe; imaging system; medical schools; mid-career faculty; neurovascular; novel therapeutics; prototype; radio frequency; single photon emission computed tomography; stem cell therapy; structural heart disease; theranostics

Summary We are requesting funds to purchase an interventional ultrasound system (Epiq CVxi, Philips) with 2D and 3D transthoracic, 3D transesophageal, high frequency vascular imaging probes, abdominal probe, and non-imaging Doppler probes for a wide range of NIH funded projects. This system will replace an ultrasound imaging system (iE33, Philips Healthcare) that has been successfully operated as a shared imaging resource in the Yale Translational Research Imaging Center (Y-TRIC) for over 10 years. The existing system was initially acquired as part of a NIH funded Bioengineering Research Partnership with Philips Healthcare in 2006 to develop radiofrequency (RF) based 3-dimensional (3D) echocardiography speckle tracking for comprehensive analysis of regional myocardial strain. The existing ultrasound system has reached end of life and was equipped with a prototype RF capture board that can no longer be serviced. The EPIQ CVxi system is a state-of-the-art ultrasound system that includes hardware upgrades that are specifically tailored for interface and use with our existing interventional fluoroscopic C-arm X-ray unit (Allura Xper FD20, Philips) for ultrasound image guidance, as well as interface with our existing hybrid CZT SPECT 64-slice CT system (Discovery NMCT570, GE Healthcare). Integration of echocardiographic images with x-ray fluoroscopy is critical for image guided interventions in the current era of catheter-based treatment of congenital heart disease and adult structural heart disease, ischemic heart disease, and electrophysiological interventions. Fused real-time 3D transesophageal echocardiography and x-ray fluoroscopy is currently used for percutaneous mitral valve and aortic valve procedures, and treatment of complex congenital anomalies. Multimodality image guided percutaneous procedures are now replacing conventional cardiac surgery for treatment of these conditions. In the future multimodality image fusion will help to guide intramyocardial delivery of novel therapeutics and theranostics to the heart, including; gene therapy, stem cell therapy, or drug releasing polymer therapies. The use of the system goes beyond application in the cardiovascular system and involves projects related to assessment of neurovascular function, optimization of SPECT and PET imaging, treatment of hepatic cancer, and evaluation of organs for transplantation. The system will be used for 7 major and 4 additional minor NIH funded projects by investigators at the School of Medicine and School of Engineering and Applied Sciences. The imaging resources within Y-TRIC and associated faculty are highly qualified to optimize the utilization of the interventional ultrasound system and are uniquely positioned to facilitate training of the new leaders in multimodality imaging and ultrasound guided interventions.

总结 我们正在申请资金，用于购买2D介入超声系统（Epiq CVxi，Philips） 和3D经胸、3D经食管、高频血管成像探头、腹部探头，以及 非成像多普勒探头用于NIH资助的各种项目。这个系统将取代超声波 成像系统（iE 33，Philips Healthcare）已成功用作共享成像资源 在耶鲁大学转化研究成像中心（Y-TRIC）工作了10多年。现行制度是 最初于2006年作为NIH资助的生物工程研究合作伙伴关系的一部分与飞利浦医疗保健公司收购 开发基于射频（RF）的三维（3D）超声心动图斑点追踪， 局部心肌劳损综合分析。现有超声系统已达到使用寿命 并配备了一个原型射频捕获板，可以不再维修。EPIQ CVxi系统 最先进的超声系统，包括专门针对接口定制的硬件升级 并与我们现有的介入透视C形臂X射线装置（Allura Xper FD 20，Philips）配合使用，用于超声检查 图像引导，以及与我们现有的混合CZT SPECT 64层CT系统（Discovery）的接口 NMCT 570，GE Healthcare）。超声心动图图像与X射线透视的整合对于图像的质量至关重要。 在当前以导管为基础的先天性心脏病和成人心脏病治疗的时代， 结构性心脏病、缺血性心脏病和电生理干预。融合实时3D 经食管超声心动图和X射线荧光透视目前用于经皮二尖瓣， 主动脉瓣手术和复杂先天性畸形的治疗。多模态图像引导 经皮手术现在正在取代传统的心脏手术来治疗这些病症。在 未来的多模态图像融合将有助于指导新疗法的心肌内递送， 心脏治疗诊断学，包括基因治疗、干细胞治疗或药物释放聚合物治疗。的 该系统的使用超出了心血管系统的应用范围， 评估神经血管功能，优化SPECT和PET成像，治疗肝癌， 和器官移植评估。该系统将用于7个主要和4个额外的次要NIH 由医学院和工程与应用科学学院的研究人员资助的项目。 在Y-TRIC和相关教师的成像资源是高素质的，以优化利用 介入超声系统和独特的定位，以促进新的领导人的培训， 多模态成像和超声引导介入。