Ultrasound System for Transational Research

用于转化研究的超声系统

• 批准号: 10177501
• 负责人: Albert J Sinusas
• 金额: $ 58.97万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2022-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177501
• 关键词: 3-Dimensional; Abdomen; Adult; Applied Research; Biomedical Engineering; Blood Vessels; Cardiac Surgery procedures; Cardiovascular system; Catheters; Complex; DCNU; Echocardiography; Electrophysiology (science); Engineering; Evaluation; Fluoroscopy; Frequencies; Funding; Future; Healthcare; Heart; Hybrids; Image; Intervention; Interventional Ultrasonography; Malignant neoplasm of liver; Minor; Mitral Valve; Multimodal Imaging; Myocardial; Myocardial Ischemia; Organ Transplantation; Pharmaceutical Preparations; Polymers; Positioning Attribute; Positron-Emission Tomography; Procedures; Research; Research Personnel; Resources; Roentgen Rays; Schools; Services; Slice; System; Time; Training; Transesophageal Echocardiography; Translational Research; Ultrasonography; United States National Institutes of Health; aortic valve; arm; base; congenital anomaly; congenital heart disorder; end of life; gene therapy; image guided; image guided intervention; imaging probe; imaging system; medical schools; mid-career faculty; neurovascular; novel therapeutics; prototype; radio frequency; single photon emission computed tomography; stem cell therapy; structural heart disease; theranostics

Summary We are requesting funds to purchase an interventional ultrasound system (Epiq CVxi, Philips) with 2D and 3D transthoracic, 3D transesophageal, high frequency vascular imaging probes, abdominal probe, and non-imaging Doppler probes for a wide range of NIH funded projects. This system will replace an ultrasound imaging system (iE33, Philips Healthcare) that has been successfully operated as a shared imaging resource in the Yale Translational Research Imaging Center (Y-TRIC) for over 10 years. The existing system was initially acquired as part of a NIH funded Bioengineering Research Partnership with Philips Healthcare in 2006 to develop radiofrequency (RF) based 3-dimensional (3D) echocardiography speckle tracking for comprehensive analysis of regional myocardial strain. The existing ultrasound system has reached end of life and was equipped with a prototype RF capture board that can no longer be serviced. The EPIQ CVxi system is a state-of-the-art ultrasound system that includes hardware upgrades that are specifically tailored for interface and use with our existing interventional fluoroscopic C-arm X-ray unit (Allura Xper FD20, Philips) for ultrasound image guidance, as well as interface with our existing hybrid CZT SPECT 64-slice CT system (Discovery NMCT570, GE Healthcare). Integration of echocardiographic images with x-ray fluoroscopy is critical for image guided interventions in the current era of catheter-based treatment of congenital heart disease and adult structural heart disease, ischemic heart disease, and electrophysiological interventions. Fused real-time 3D transesophageal echocardiography and x-ray fluoroscopy is currently used for percutaneous mitral valve and aortic valve procedures, and treatment of complex congenital anomalies. Multimodality image guided percutaneous procedures are now replacing conventional cardiac surgery for treatment of these conditions. In the future multimodality image fusion will help to guide intramyocardial delivery of novel therapeutics and theranostics to the heart, including; gene therapy, stem cell therapy, or drug releasing polymer therapies. The use of the system goes beyond application in the cardiovascular system and involves projects related to assessment of neurovascular function, optimization of SPECT and PET imaging, treatment of hepatic cancer, and evaluation of organs for transplantation. The system will be used for 7 major and 4 additional minor NIH funded projects by investigators at the School of Medicine and School of Engineering and Applied Sciences. The imaging resources within Y-TRIC and associated faculty are highly qualified to optimize the utilization of the interventional ultrasound system and are uniquely positioned to facilitate training of the new leaders in multimodality imaging and ultrasound guided interventions.

摘要 我们正在申请购买2D介入性超声系统(Epiq CVxi，飞利浦)的资金 以及3D经胸、3D经食道、高频血管成像探头、腹部探头以及 非成像多普勒探头，适用于美国国立卫生研究院资助的广泛项目。这个系统将取代超声波 成像系统(iE33，飞利浦医疗)，已作为共享成像资源成功运营 在耶鲁大学翻译研究成像中心(Y-TIC)工作了10多年。现有的制度是 最初是作为NIH资助的生物工程研究伙伴关系的一部分于2006年与飞利浦医疗公司收购的 开发基于射频(RF)的三维(3D)超声心动图斑点追踪技术 局部心肌应变的综合分析。现有的超声波系统已到了使用寿命的尽头 并配备了无法再维修的射频采集板原型。EPIQ CVxi系统是 最先进的超声系统，包括专门为接口量身定做的硬件升级 并与我们现有的介入性透视C臂X光机(Allura Xper FD20，飞利浦)一起用于超声 图像引导，以及与我们现有的混合式CZT SPECT层CT系统(Discovery)的接口 NMCT570、GE Healthcare)。超声心动图图像与x射线透视图像的集成是图像处理的关键 当前先心病和成人导管治疗时代的指导性干预 结构性心脏病、缺血性心脏病和电生理干预。融合的实时3D 经食道超声心动图和x射线透视目前用于经皮二尖瓣和 主动脉瓣手术和复杂先天性畸形的治疗。多通道图像制导 对于这些疾病的治疗，经皮手术现在正在取代传统的心脏手术。在……里面 未来的多模式图像融合将有助于指导新的治疗方法和 对心脏的治疗，包括基因治疗、干细胞治疗或药物释放聚合物治疗。这个 该系统的使用超越了在心血管系统中的应用，并涉及到与以下项目相关的项目 神经血管功能评估，SPECT和PET成像的优化，肝癌的治疗， 以及移植器官的评估。该系统将用于7个主要和4个额外的NIH次要 由医学院和工程与应用科学学院的研究人员资助的项目。 Y-tric及其相关教职员工的影像资源高度合格，可以优化 介入性超声系统和独特的定位，以促进培训新的领导者在 多模式成像和超声引导介入。