Translational SPECT/CT Imaging System

平移 SPECT/CT 成像系统

• 批准号: 10424888
• 负责人: Albert J Sinusas
• 金额: $ 162.67万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10424888
• 关键词: Animal Experimentation; Animals; Applications Grants; Biomedical Engineering; Blood flow; Cadaver; Cardiac; CdZnTe; Clinical Research; Complement; Disease; Environment; Equipment; Evaluation; Funding; Grant; Healthcare; Human; Hybrids; Image; Institution; Internal Medicine; Isotopes; Molecular Target; Morphologic artifacts; Motion; Operative Surgical Procedures; Pilot Projects; Positioning Attribute; Positron-Emission Tomography; Radioisotopes; Research Personnel; Resolution; Resources; Scanning; System; Technology; Time; Translational Research; United States National Institutes of Health; Universities; X-Ray Computed Tomography; attenuation; base; biomedical imaging; clinical center; clinical investigation; detector; heart motion; imaging facilities; imaging system; improved; instrument; instrumentation; kinetic model; medical schools; molecular imaging; radiological imaging; radiotracer; respiratory; single photon emission computed tomography; whole body imaging; working group

Summary This high-end shared instrument grant proposal is to replace the existing hybrid SPECT/CT scanner (Discovery NMCT570c, GE Healthcare) that was purchased in 2010 with a shared instrumentation grant (1 S10 RR025555-01) entitled, “Hybrid Volumetric SPECT/CT Imaging System”, with a new SPECT/CT that has 12 cadmium zinc telluride (CZT) detector modules in a unique 360° configuration with adaptable detector position and angle. This new CZT-based SPECT technology is capable of focused or whole-body imaging and will be applied for radionuclide targeted molecular imaging in larger animals in evaluation of a wide variety of diseases. The new CZT detector system will provide improved sensitivity and spatial resolution, bringing the SPECT technology closer to that of PET. The proposed hybrid scanner will facilitate correction for errors attributed to attenuation, scatter, partial volume effects, and radiotracer crosstalk during dual isotope acquisitions facilitating quantitative SPECT radiotracer-based molecular imaging. The high sensitivity of the technology will also enable ultra-fast dynamic SPECT imaging, which should prove to be extremely valuable for determining the biokinetics of new targeted radiotracers and allows for the determination of absolute blood flow through established kinetic modeling approaches. The high sensitivity also allows for shorter scan times as well as respiratory and cardiac gating which will minimize the possibility of subject and/or cardiac motion and therefore reduce motion related artifacts. The proposed system will enhance our established translational facilities for imaging of both small and large animals, human cadavers, and facilitate translational research at our institution. The CZT-based SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Internal Medicine, Radiology & Biomedical Imaging, Surgery, and from the Department of Biomedical Engineering at Yale University as well as investigators at multiple other academic institutions throughout the US. The user group works on a variety of projects, which would utilize different features of the proposed equipment. The upgraded hybrid SPECT/CT imaging system will become an integral part of the Yale Translational Imaging Center (Y- TRIC), which has co-located large animal holding and surgery facilities with state-of-the-art imaging resources for translational animal research. This center will nicely complement our current Yale Center for Clinical Investigation (YCCI), which has been repeatedly funded by an NIH CTSA grant for establishing an integrated environment for clinical and translational research. Funds will be available through the YCCI to fund pilot projects from new investigators to assure expanded utilization of the system.

总结 这项高端共享仪器赠款提案将取代现有的混合SPECT/CT扫描仪（Discovery NMCT 570 c，GE Healthcare），该设备于2010年通过共享仪器赠款（1 S10）购买 RR 025555 -01），标题为“混合容积SPECT/CT成像系统”，具有12个 碲锌镉（CZT）探测器模块，采用独特的360°配置，探测器位置可调 和角度。这种新的基于CZT的SPECT技术能够进行聚焦或全身成像， 应用于大型动物的放射性核素靶向分子成像，以评价各种 疾病新的CZT探测器系统将提高灵敏度和空间分辨率， SPECT技术更接近PET。拟议的混合扫描仪将有助于纠正错误 归因于双同位素期间的衰减、散射、部分体积效应和放射性示踪剂串扰。 采集促进定量SPECT放射性示踪剂为基础的分子成像。的高灵敏度 这项技术还将使超快速动态SPECT成像成为可能，这将被证明是非常有价值的 用于测定新靶向放射性示踪剂的生物活性，并允许测定绝对血液 通过已建立的动力学建模方法流动。高灵敏度还允许更短的扫描时间 以及呼吸和心脏门控 并因此减少运动相关的伪像。拟议的系统将加强我们既定的翻译 小型和大型动物，人类尸体的成像设施，并促进转化研究， 我们的机构基于CZT的SPECT/CT成像系统将支持当前多个NIH的需求 耶鲁大学医学院的研究人员，来自内科， 耶鲁大学生物医学工程系的放射学和生物医学成像、外科和 大学以及美国其他多个学术机构的研究人员。用户组 在各种项目中工作，这些项目将利用拟议设备的不同功能。升级后的 混合SPECT/CT成像系统将成为耶鲁平移成像中心（Yale Translational Imaging Center，简称Y-CT）的一个组成部分。 TRIC），拥有位于同一地点的大型动物饲养和手术设施以及最先进的成像资源 用于转化动物研究。该中心将很好地补充我们目前的耶鲁临床中心， 研究（YCCI），它已多次由NIH CTSA赠款资助，用于建立一个综合的 临床和转化研究的环境。资金将通过YCCI提供，以资助试点 新调查员的项目，以确保扩大该系统的利用。