Ultra-high Performance MicroSPECT/CT system

超高性能 MicroSPECT/CT 系统

• 批准号: 9089310
• 负责人: Albert J Sinusas
• 金额: $ 60万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9089310
• 关键词: Animals; Biodistribution; Cardiac; Collimator; Data; Diagnostic radiologic examination; Funding; Goals; Grant; Heart Atrium; Hybrids; Image; Kinetics; Laboratories; Lung; Magnetic Resonance Imaging; Measurement; Medicine; Modeling; Mus; Myocardium; Organ; Pathology; Performance; Positron-Emission Tomography; Radioisotopes; Rattus; Research Personnel; Resolution; System; United States National Institutes of Health; Universities; X-Ray Computed Tomography; attenuation; imaging modality; imaging system; in vivo; instrument; instrumentation; medical schools; meetings; microSPECT; molecular imaging; programs; radiation absorbed dose; radiotracer; respiratory; single photon emission computed tomography; uptake; working group

 DESCRIPTION (provided by applicant): This shared instrument proposal is for purchase of a hybrid multi-collimator microSPECT/CT imaging system (MILabs MicroSPECT4CT), with a goal of high resolution, high sensitivity radionuclide targeted molecular imaging in small animals. The proposed state-of-the-art SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Laboratory Medicine, and Pathology. The user group worked on a variety of projects, which would utilize multiple features of the camera including the proposed four different collimators. The 4 different collimators provide options for high resolutio and high sensitivity in both rat and moues models. Additionally, this system can acquire cardiac and respiratory gated images in addition to list mode data for high sensitivity dynamic imaging. The combined SPECT and CT unit provides inherent registration of functional SPECT images with high resolution and anatomical CT images for the purpose of image quantification. The CT images allow for correction of attenuation and partial volume errors associated with SPECT imaging, permitting absolute quantification of radiotracer uptake. These system features are critical for our program wherein we have a spectrum of NIH funded programs from assessment of mouse atria to dynamic flow measurements in the rat myocardium or lungs. To obtain FDA approval for an IND, this system can be used to evaluate in vivo targeted radiotracers for biodistribution, specific organ uptake and clearance kinetics. The merging of SPECT and CT data will also facilitate MIRD calculations for estimation of absorbed radiation dose. The registration of SPECT and CT data will also facilitate correlation of SPECT images with independently acquired PET and MR images as we moved towards multi-modality imaging projects. Thus, the proposed system would meet all of the needs of the investigators of this shared instrumentation grant, allowing for high resolution, high sensitivity imaging in small animals and absolute quantification of radiotracer uptake.

 描述（由适用提供）：此共享仪器提案用于购买混合多胶体微光谱/CT成像系统（MILABS Microspect4CT），其目标是高分辨率，高灵敏度放射线射线杆菌靶向的分子成像。拟议的最先进的SPECT/CT成像系统将在耶鲁大学医学院，医学，诊断放射学，实验室医学和病理学部门的多个现任NIH资助的研究人员的需求。用户组从事各种项目，这些项目将利用相机的多个功能，包括提议的四个不同的准仪。这4种不同的准直仪为大鼠和穆斯模型的高分辨率和高灵敏度提供了选择。此外，此系统除了列表模式数据以进行高灵敏度动态成像外，还可以获取心脏和呼吸道封闭图像。组合SPECT和CT单元提供了具有高分辨率和解剖CT图像的功能SPECT图像的固有编码，以进行图像定量。 CT图像允许校正与SPECT成像相关的衰减和部分体积误差，从而可以绝对定量放射性示意剂摄取。这些系统功能对于我们的程序至关重要，在我们的程序中，我们拥有一系列NIH资助的计划，从评估小鼠心房到大鼠心肌或肺的动态流量测量。为了获得IND的FDA批准，该系统可用于评估体内靶向放射性示踪剂的生物分布，特定器官摄取和清除动力学。 SPECT和CT数据的合并还将促进MIRD计算，以估算吸收的辐射剂量。当我们朝着多模式成像项目迈进时，SPECT和CT数据的注册还将促进SPECT图像与独立获取的PET和MR图像的相关性。这是拟议的系统将满足该共享仪器赠款的研究人员的所有需求，从而可以高分辨率，小动物中的高灵敏度成像以及对放射性示意剂摄取的绝对定量。