Ultra-high Performance MicroSPECT/CT system

超高性能 MicroSPECT/CT 系统

• 批准号: 9089310
• 负责人: Albert J Sinusas
• 金额: $ 60万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9089310
• 关键词: Animals; Biodistribution; Cardiac; Collimator; Data; Diagnostic radiologic examination; Funding; Goals; Grant; Heart Atrium; Hybrids; Image; Kinetics; Laboratories; Lung; Magnetic Resonance Imaging; Measurement; Medicine; Modeling; Mus; Myocardium; Organ; Pathology; Performance; Positron-Emission Tomography; Radioisotopes; Rattus; Research Personnel; Resolution; System; United States National Institutes of Health; Universities; X-Ray Computed Tomography; attenuation; imaging modality; imaging system; in vivo; instrument; instrumentation; medical schools; meetings; microSPECT; molecular imaging; programs; radiation absorbed dose; radiotracer; respiratory; single photon emission computed tomography; uptake; working group

 DESCRIPTION (provided by applicant): This shared instrument proposal is for purchase of a hybrid multi-collimator microSPECT/CT imaging system (MILabs MicroSPECT4CT), with a goal of high resolution, high sensitivity radionuclide targeted molecular imaging in small animals. The proposed state-of-the-art SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Laboratory Medicine, and Pathology. The user group worked on a variety of projects, which would utilize multiple features of the camera including the proposed four different collimators. The 4 different collimators provide options for high resolutio and high sensitivity in both rat and moues models. Additionally, this system can acquire cardiac and respiratory gated images in addition to list mode data for high sensitivity dynamic imaging. The combined SPECT and CT unit provides inherent registration of functional SPECT images with high resolution and anatomical CT images for the purpose of image quantification. The CT images allow for correction of attenuation and partial volume errors associated with SPECT imaging, permitting absolute quantification of radiotracer uptake. These system features are critical for our program wherein we have a spectrum of NIH funded programs from assessment of mouse atria to dynamic flow measurements in the rat myocardium or lungs. To obtain FDA approval for an IND, this system can be used to evaluate in vivo targeted radiotracers for biodistribution, specific organ uptake and clearance kinetics. The merging of SPECT and CT data will also facilitate MIRD calculations for estimation of absorbed radiation dose. The registration of SPECT and CT data will also facilitate correlation of SPECT images with independently acquired PET and MR images as we moved towards multi-modality imaging projects. Thus, the proposed system would meet all of the needs of the investigators of this shared instrumentation grant, allowing for high resolution, high sensitivity imaging in small animals and absolute quantification of radiotracer uptake.

 描述（由申请人提供）：该共享仪器提案用于购买混合多准直器microSPECT/CT成像系统（MILabs MicroSPECT 4CT），目标是在小动物中进行高分辨率、高灵敏度放射性核素靶向分子成像。拟议的最先进的SPECT/CT成像系统将支持耶鲁大学医学院多个当前NIH资助的研究人员的需求，这些研究人员来自医学系、诊断放射学系、实验室医学系和病理学系。用户组参与了各种项目，这些项目将利用相机的多个功能，包括拟议的四个不同的准直器。4种不同的准直器为大鼠和小鼠模型提供了高分辨率和高灵敏度的选择。此外，该系统除了用于高灵敏度动态成像的列表模式数据之外，还可以采集心脏和呼吸门控图像。组合的SPECT和CT单元提供功能SPECT图像与高分辨率和解剖CT图像的固有配准，以用于图像量化。CT图像允许校正与SPECT成像相关的衰减和部分体积误差，允许绝对定量放射性示踪剂摄取。这些系统功能对我们的项目至关重要，其中我们有一系列NIH资助的项目，从小鼠心房的评估到大鼠心肌或肺的动态流量测量。为了获得FDA对IND的批准，该系统可用于评估体内靶向放射性示踪剂的生物分布、特定器官摄取和清除动力学。SPECT和CT数据的合并也将有助于MIRD计算，以估计吸收的辐射剂量。当我们转向多模态成像项目时，SPECT和CT数据的配准还将促进SPECT图像与独立采集的PET和MR图像的相关性。因此，拟议的系统将满足所有的需要，研究人员的这种共享仪器赠款，允许高分辨率，高灵敏度成像的小动物和绝对定量的放射性示踪剂摄取。