Hybrid Volumetric SPECT/CT Imaging System

混合体积 SPECT/CT 成像系统

• 批准号: 7595639
• 负责人: Albert J Sinusas
• 金额: $ 50万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2010-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595639
• 关键词: Anesthesiology; Animal Experimentation; Animals; Arts; Biomedical Engineering; Blood Vessels; Clinical; Clinical Trials; Complement; Development; Diagnostic radiologic examination; Environment; Equipment; Funding; Future; Goals; Grant; Head; Healthcare; Hybrids; Image; Institution; Medical; Medicine; Operative Surgical Procedures; Phase; Pilot Projects; Radioisotopes; Research Personnel; Resources; Rodent; System; Technology; Testing; Translational Research; United States National Institutes of Health; Universities; Validation; X-Ray Computed Tomography; attenuation; improved; instrument; medical schools; molecular imaging; programs; public health relevance; radiotracer; single photon emission computed tomography; uptake; working group

DESCRIPTION (provided by applicant): This shared instrument proposal is for replacement of a dual-head SPECT Imaging System (Millenium VG, GE healthcare) with a hybrid dual-head volumetric SPECT/CT imaging system (Brightview VCT, Philips Medical Systems, Inc.), with a goal of radionuclide targeted molecular imaging in larger non-rodent animals. The proposed imaging system will complement our established facilities for imaging of both small and large animals and facilitate translational research at our institution. The proposed state- of-the-art SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Surgery, and Anesthesiology, and the Department of Biomedical Engineering at Yale University. The user group works on a variety of projects, which would utilize different features of the proposed equipment. The combined SPECT and X-ray CT unit provides inherent registration of functional SPECT images with anatomical CT images for the purpose of image quantification. The CT images allow for correction of attenuation and partial volume errors associated with SPECT imaging, permitting absolute quantification of radiotracer uptake. This system feature will be critical for the development of a program in targeted molecular imaging. The proposed hybrid volumetric SPECT/CT imaging will become an integral part of the Yale Translational Animal Center (Y-TRAC), which is under phase development, and will co-locate large animal holding and surgery facilities with state-of-the-art imaging resources for translational animal research. This center will nicely complement our current Yale Center for Clinical Investigation(YCCI), which was recently funded by an NIH CTSA grant for establishing an integrated environment for clinical and translational research. Funds will be available through the YCCI to fund pilot projects from new investigators. PUBLIC HEALTH RELEVANCE: The proposed state-of-the-art SPECT/CT imaging system will support the translational research of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Surgery, and Anesthesiology, and the Department of Biomedical Engineering at Yale University. The imaging system will allow for the testing and validation of experimental molecular imaging agents and bioengineered blood vessels. The successful development of these types of cutting edge technologies will provide for improved and personalized health care in the future.

描述（由申请人提供）：该共享的仪器提案是用于用混合双头体积体积/CT成像系统（Brightview VCT，Philips Medical Systems，Inc。）更换双头Spect Imaging系统（Millenium VG，GE Healthcare），具有放射性靶核靶核靶核靶向分子型动物的目标。拟议的成像系统将补充我们既定的小型动物和大型动物成像的设施，并促进我们机构的转化研究。拟议的状态SPECT/CT成像系统将支持耶鲁大学医学院的多个现任NIH资助的研究人员的需求，该研究人员来自医学，诊断放射学，手术和麻醉学系，以及耶鲁大学生物医学工程系的需求。用户组从事各种项目，这些项目将利用所提出的设备的不同功能。组合的SPECT和X射线CT单元提供了具有解剖CT图像的功能SPECT图像的固有编码，以实现图像量化的目的。 CT图像允许校正与SPECT成像相关的衰减和部分体积误差，从而可以绝对定量放射性示意剂摄取。此系统功能对于在靶向分子成像中开发程序的开发至关重要。拟议的混合体积SPECT/CT成像将成为耶鲁转化动物中心（Y-TRAC）的组成部分，该中心正在阶段发育中，并将将大型动物持有和手术设施与先进的成像资源共同为转化动物研究。该中心将很好地补充我们当前的耶鲁临床研究中心（YCCI），该中心最近由NIH CTSA赠款资助，用于建立临床和转化研究的综合环境。资金将通过YCCI提供，以资助新调查人员的试点项目。 公共卫生相关性：拟议的最先进的SPECT/CT成像系统将支持耶鲁大学医学院的多个现有NIH资助的研究人员的转化研究，来自医学，诊断放射学，手术和麻醉学部门以及耶鲁大学生物医学工程系。成像系统将允许对实验分子成像剂和生物工程血管进行测试和验证。这些类型的尖端技术的成功开发将在未来提供改进和个性化的医疗保健。

项目成果

End-expiration respiratory gating for a high-resolution stationary cardiac SPECT system.

• DOI: 10.1088/0031-9155/59/20/6267
• 发表时间: 2014-10-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Chan C;Harris M;Le M;Biondi J;Grobshtein Y;Liu YH;Sinusas AJ;Liu C
• 通讯作者: Liu C