Mount Sinai HHEAR Network Untargeted Lab Hub

西奈山 HHEAR 网络非目标实验室中心

• 批准号: 10176494
• 负责人: Manish Arora
• 金额: $ 157.24万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176494
• 关键词: Address; Adolescence; Adult; Affect; Age; Analytical Chemistry; Archives; Automatic Data Processing; Behavioral; Biological; Biological Assay; Biological Markers; Blood; Cellular Structures; Charge; Chemical Exposure; Chemicals; Childhood; Chronic Disease; Client; Communication; Complex; Consultations; Creativeness; Data; Data Scientist; Data Set; Development; Developmental Biology; Disease; Dose; Ensure; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Risk Factor; Exposure to; Faculty; Funding; Genes; Genetic; Genomics; Goals; Grant; Growth; Hair; Health; Human; Institutes; Investments; Laboratories; Life; Life Cycle Stages; Link; Liquid substance; Longevity; Measures; Methodology; Methods; Mind; Mission; Modeling; Molecular; Molecular Biology; Nature; Neonatal; Occupations; Outcome; Pathogenicity; Pathway interactions; Phenotype; Physiological; Placenta; Plant Roots; Preparation; Procedures; Prospective cohort; Proteomics; Protocols documentation; Public Health; Research; Research Personnel; Resources; Sampling; Science; Services; Shipping; Speed; Spottings; Technology; Time; Tooth structure; Toxicokinetics; United States; United States National Institutes of Health; Work; base; case control; clinical practice; critical period; data centers; design; disability; disorder risk; environmental chemical; epidemiology study; fetal; flexibility; gene environment interaction; innovation; instrumentation; interest; lipidomics; mass spectrometer; medical schools; metabolomics; microbiome; microbiome research; microorganism; molecular dynamics; multidisciplinary; novel; novel marker; operation; prenatal; programs; response; sample collection; social; social stressor

PROJECT SUMMARY/ABSTRACT FOR OVERALL The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub (formerly known as “CHEAR” in grant cycle 1). We will use a suite of `omic' technologies to measure environmental exposures and their response across all life stages to help NIH funded researchers determine how the environment affects human health, development and risk of disease across the life span. In the last 3 years we have expanded our laboratory resources to include liquid handlers to automate sample prep/aliquoting and worked with data scientist to automate data processing to speed the pace of our jobs. In addition we doubled the number of mass spectrometers from 7 to 14 and hired additional faculty all in preparation for this renewal application. We will leverage our substantial institutional investments, including our new $30 million Institute for Exposomics, to serve the HHEAR Lab network and its NIH researcher clients. Our Untargeted Resource will use molecular enviromics and metabolomics to measure exposure to environmental chemicals and their metabolites as well as the internal response to those exposures. We will supplement those measures with metallomics, proteomics and lipidomics. However, we are cognizant of the ever-changing landscape of health research and have included Microbiome and Viromics to prempt the NIH funded researchers' interest in including these measures to existing studies. We have state-of- the-art analytical methodologies and instrumentation that were made available to CHEAR users. While we will continue to offer these well-established methods to HHEAR clients, we are also committed to listening to the needs of HHEAR users and develop new biomarkers to meet those needs. Our Developmental core will build upon its highly successful work in creating novel methods to measure current and past chemical exposures in novel biological matrices (e.g. teeth, hair, placenta, neonatal dry blood spots) and develop new assays that arise from HHEAR's targeted and environmental resources. Our Administrative Core will coordinate planning and communication internally among all Hub components and externally with the HHEAR Coordinating Center, Data Center and the other HHEAR Network Hubs. Internally, the Administrative Core will streamline and prioritize HHEAR jobs, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day-to-day operations. Our Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications and guide them to the most innovative environmental health science.

整体项目摘要/摘要 西奈山的伊坎医学院将利用我们在环境中的研究专业知识 流行病学，分析化学和临床实践，以更新我们的人类健康暴露分析 资源（HHEAR）实验室网络中心（以前称为赠款周期1中的“ Chear”）。我们将使用一个 “ OMIC”技术套件，以衡量环境暴露及其在所有生命阶段的反应 帮助NIH资助的研究人员确定环境如何影响人类健康，发展和风险 整个寿命中的疾病。在过去的三年中，我们扩展了实验室资源以包括液体 处理人员自动化样本准备/等分试样，并与数据科学家合作以使数据处理自动化 加快工作空间。另外，我们将质谱仪的数量从7增加到14增加一倍，并雇用 其他教师都为此续签申请做准备。我们将利用我们的大量机构 投资，包括我们新的3000万美元的外汇研究所，以服务于HHEAR LAB Network及其 NIH研究人员客户。我们未靶向的资源将使用分子环境和代谢组学来测量 暴露于环境化学物质及其代谢物以及对那些的内部反应 暴露。我们将通过金属学，蛋白质组学和脂肪组学补充这些措施。但是，我们是 认识到不断变化的健康研究景观，并包括微生物组和病毒学 宣布NIH资助的研究人员对将这些措施包括在现有研究中的兴趣。我们有最新 使用向Chear用户提供的ART分析方法和仪器。虽然我们会的 继续向Hhear客户提供这些完善的方法，我们还致力于听取 Hear用户的需求并开发新的生物标志物以满足这些需求。我们的发展核心将建立 一项在创建新颖的方法来测量当前和过去的化学暴露的新方法方面的成功工作 新型生物矩阵（例如牙齿，头发，胎盘，新生儿干血点），并开发了新的测定法 由HHEAR的目标和环境资源产生。我们的行政核心将协调计划 在所有枢纽组件中的内部进行通信以及与Hear协调中心的外部交流， 数据中心和其他HHEAR网络中心。在内部，行政核心将简化，并且 优先考虑HHEAR工作，评估需求，促进和传播新的测定法， 协调协议和QA/QC程序，并协调日常操作。我们的枢纽会建议 申请样品需求，样本质量，结果解释，样本收集，存储协议 并采样运输规格，并将其引导到最具创新性的环境健康科学。