Mount Sinai HHEAR Network Untargeted Lab Hub

西奈山 HHEAR 网络非目标实验室中心

• 批准号: 10675524
• 负责人: Manish Arora
• 金额: $ 125万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10675524
• 关键词: Acceleration; Adolescence; Adult; Affect; Age; Analytical Chemistry; Archives; Automatic Data Processing; Behavioral; Biological; Biological Assay; Biological Markers; Blood; Cellular Structures; Charge; Chemical Exposure; Chemicals; Childhood; Chronic Disease; Client; Communication; Complex; Consultations; Creativeness; Data; Data Scientist; Data Set; Development; Developmental Biology; Disease; Dose; Dryness; Ensure; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Risk Factor; Exposure to; Faculty; Funding; Genes; Genetic; Genomics; Goals; Grant; Growth; Hair; Health; Human; Institution; Investments; Laboratories; Life; Life Cycle Stages; Link; Liquid substance; Longevity; Measures; Methodology; Methods; Mission; Modeling; Molecular; Molecular Biology; Nature; Neonatal; Occupations; Outcome; Pathogenicity; Pathway interactions; Persons; Phenotype; Physiological; Placenta; Preparation; Procedures; Prospective cohort; Proteomics; Protocols documentation; Public Health; Research; Research Personnel; Resources; Risk; Sampling; Science; Services; Shipping; Specific qualifier value; Speed; Spottings; Technology; Time; Tooth structure; Toxicokinetics; United States; United States National Institutes of Health; Work; case control; clinical practice; complex data; critical period; data centers; design; disability; disorder risk; environmental chemical; epidemiology study; fetal; flexibility; gene environment interaction; innovation; instrumentation; interest; lipidomics; mass spectrometer; medical schools; metabolomics; microbiome; microbiome research; microorganism; molecular dynamics; multidisciplinary; novel; novel marker; operation; prenatal; programs; response; sample collection; social; stressor

PROJECT SUMMARY/ABSTRACT FOR OVERALL The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub (formerly known as “CHEAR” in grant cycle 1). We will use a suite of `omic' technologies to measure environmental exposures and their response across all life stages to help NIH funded researchers determine how the environment affects human health, development and risk of disease across the life span. In the last 3 years we have expanded our laboratory resources to include liquid handlers to automate sample prep/aliquoting and worked with data scientist to automate data processing to speed the pace of our jobs. In addition we doubled the number of mass spectrometers from 7 to 14 and hired additional faculty all in preparation for this renewal application. We will leverage our substantial institutional investments, including our new $30 million Institute for Exposomics, to serve the HHEAR Lab network and its NIH researcher clients. Our Untargeted Resource will use molecular enviromics and metabolomics to measure exposure to environmental chemicals and their metabolites as well as the internal response to those exposures. We will supplement those measures with metallomics, proteomics and lipidomics. However, we are cognizant of the ever-changing landscape of health research and have included Microbiome and Viromics to prempt the NIH funded researchers' interest in including these measures to existing studies. We have state-of- the-art analytical methodologies and instrumentation that were made available to CHEAR users. While we will continue to offer these well-established methods to HHEAR clients, we are also committed to listening to the needs of HHEAR users and develop new biomarkers to meet those needs. Our Developmental core will build upon its highly successful work in creating novel methods to measure current and past chemical exposures in novel biological matrices (e.g. teeth, hair, placenta, neonatal dry blood spots) and develop new assays that arise from HHEAR's targeted and environmental resources. Our Administrative Core will coordinate planning and communication internally among all Hub components and externally with the HHEAR Coordinating Center, Data Center and the other HHEAR Network Hubs. Internally, the Administrative Core will streamline and prioritize HHEAR jobs, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day-to-day operations. Our Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications and guide them to the most innovative environmental health science.

总体项目摘要/摘要

项目成果

An annotation database for chemicals of emerging concern in exposome research.

• DOI: 10.1016/j.envint.2021.106511
• 发表时间: 2021-03
• 期刊: Environment international
• 影响因子: 11.8
• 作者: J. Meijer;M. Lamoree;T. Hamers;J. Antignac;S. Hutinet;L. Debrauwer;A. Covaci;Carolin Huber;M. Krauss;D. Walker;Emma L. Schymanski;R. Vermeulen;J. Vlaanderen