Administrative Core

行政核心

• 批准号: 10453434
• 负责人: Manish Arora
• 金额: $ 18.97万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453434
• 关键词: Address; Age; Analytical Chemistry; Biological; Biological Assay; Biological Markers; Biology; Blinded; Blood; Budgets; Chemical Exposure; Chemicals; Client; Communication; Communities; Computer software; Computing Methodologies; Consultations; Counseling; Data; Data Reporting; Databases; Disease; Doctor of Philosophy; Dose; Educational workshop; Ensure; Environment; Environmental Exposure; Environmental Medicine; Epidemiology; Evaluation; Exposure to; Feedback; Fostering; Freezing; Funding; Future; Genetic study; Goals; Grant; Health; Human; Human Development; Human Resources; Institution; Label; Laboratories; Leadership; Management Information Systems; Measures; Metadata; Methodology; Methods; Mission; National Institute of Environmental Health Sciences; New York; Nutritional; Occupations; Online Systems; Organization administrative structures; Outcome; Parents; Participant; Peer Review; Phase; Phenotype; Play; Prevention; Procedures; Process; Prospective Studies; Protocols documentation; Public Health; Publications; Quality Control; Recommendation; Reporting; Research; Research Design; Research Personnel; Resources; Running; Sampling; Services; Ships; Specific Gravity; Specimen; Statistical Data Interpretation; Strategic vision; Structure; Study Subject; Sum; System; Testing; Time; Toxicology; United States National Institutes of Health; Urine; Vision; Work; arm; base; data centers; data management; design; epigenome-wide association studies; evaporation; experience; gene discovery; gene environment interaction; indexing; medical schools; meetings; metabolomics; operation; outreach; prevent; programs; prospective; quality assurance; skills; social; success; symposium; user-friendly

SUMMARY ADMINISTRATIVE CORE The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Untargeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing and common QC pools, technical replicates and blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC. We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra- Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We will then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (e.g. how specific gravity or sample evaporation may impact metabolomics measures in urine) and the statistical analysis of exposure/phenotype relationships. We will organize and implement an annual Lab Hub workshop that will engage existing and potential clients in Exposure Biology assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR – the New York Exposome Symposium (November 2 - 3, 2018) which drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Lab Hub program.

行政核心概要 行政核心是总体组织单位，是主要的沟通部门 西奈山非目标 HHEAR 实验室中心，直接与 HHEAR 协调中心 (CC) 合作， 数据中心 (DC) 和 NIH 项目工作人员。我们与其他实验室中心就 QA/QC 进行协作和沟通 计划包括能力验证和通用质量控制库、技术重复和盲法重复，以及 最小化批次效应和实验室间差异的方法，我们的团队在解决这些问题方面发挥了关键作用 CEAR 的第一个资助周期。我们进行内部协调以最大限度地提高效率，并可以灵活地改变我们的优先事项 按照CC的指示。我们每周组织中心指导委员会 (SC) 会议，以协调内部 中心工作流程，包括接收样品、重新贴标签、跟踪和进入我们的实验室 信息管理系统（LIMS）。我们组织 PI/客户咨询会议，审查 家长研究的设计、样本样本可用性、研究对象暴露场景、健康表型、 并要求测量化学品暴露的类型。然后我们将提出最适合的建议 PI/客户的目标，同时解决任何可能限制可行性的科学或技术问题 进行化验分析。我们还跟踪正在进行的工作的进展，并定期向主管部门生成报告 协调中心和 NIH 计划。我们与 HHEAR 数据中心 (DC) 协调数据报告， 确保我们的数据库格式正确并包含适当的元数据。我们也合作 与 DC 和客户/PI 一起解释结果（例如比重或样品蒸发如何影响结果） 影响尿液中的代谢组学测量）以及暴露/表型关系的统计分析。我们 将组织并实施年度实验室中心研讨会，让现有和潜在客户参与 暴露生物学测定方法。我们是在 CHEAR 下组织此类会议的唯一实验室中心 – 纽约暴露组研讨会（2018 年 11 月 2 日至 3 日）吸引了 200 名科学参与者。我们使用 基于网络的 LIMS 界面，用于通过实验室中心系统跟踪工作进度并评估 QA/QC 分析过程中实时。总之，我们 1) 协调实验室中心内部和外部的沟通 与协调中心、数据中心、PI/客户和 NIH 计划合作； 2）制定程序、协议 和系统检查，以确保样品流向正确的资源/核心，并且 QA/QC 协议符合 严格遵循； 3) 维护用户友好的 LIMS，便于样品跟踪，防止不匹配 样品和结果之间的关系，并与数据中心的需求相结合； 4）提供科学的 为 PI/客户提供咨询服务，最大限度地提高研究结果的信息和质量； 5）确保 反馈通信发生在客户端和资源/核心之间，并且该信息被中继 对 CC 和 NIH 透明，6) 确保实验室中心计划的财务管理透明。