Administrative Core
行政核心
基本信息
- 批准号:10453434
- 负责人:
- 金额:$ 18.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-11 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAnalytical ChemistryBiologicalBiological AssayBiological MarkersBiologyBlindedBloodBudgetsChemical ExposureChemicalsClientCommunicationCommunitiesComputer softwareComputing MethodologiesConsultationsCounselingDataData ReportingDatabasesDiseaseDoctor of PhilosophyDoseEducational workshopEnsureEnvironmentEnvironmental ExposureEnvironmental MedicineEpidemiologyEvaluationExposure toFeedbackFosteringFreezingFundingFutureGenetic studyGoalsGrantHealthHumanHuman DevelopmentHuman ResourcesInstitutionLabelLaboratoriesLeadershipManagement Information SystemsMeasuresMetadataMethodologyMethodsMissionNational Institute of Environmental Health SciencesNew YorkNutritionalOccupationsOnline SystemsOrganization administrative structuresOutcomeParentsParticipantPeer ReviewPhasePhenotypePlayPreventionProceduresProcessProspective StudiesProtocols documentationPublic HealthPublicationsQuality ControlRecommendationReportingResearchResearch DesignResearch PersonnelResourcesRunningSamplingServicesShipsSpecific GravitySpecimenStatistical Data InterpretationStrategic visionStructureStudy SubjectSumSystemTestingTimeToxicologyUnited States National Institutes of HealthUrineVisionWorkarmbasedata centersdata managementdesignepigenome-wide association studiesevaporationexperiencegene discoverygene environment interactionindexingmedical schoolsmeetingsmetabolomicsoperationoutreachpreventprogramsprospectivequality assuranceskillssocialsuccesssymposiumuser-friendly
项目摘要
SUMMARY ADMINISTRATIVE CORE
The Administrative Core is the overarching organizational unit and serves as the main communication arm of
the Mount Sinai Untargeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC),
Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC
programs including proficiency testing and common QC pools, technical replicates and blinded duplicates, and
methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the
first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities
as directed by the CC. We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra-
Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory
information management system (LIMS). We organize PI/Client consultation meetings in which we review the
parent study for design, sample specimen availability, study subject exposure scenarios, health phenotypes,
and requested types of chemicals exposures to be measured. We will then make recommendations that best fit
the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to
conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the
Coordinating Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC),
ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate
with the DC and Client/PI in the interpretation of results, (e.g. how specific gravity or sample evaporation may
impact metabolomics measures in urine) and the statistical analysis of exposure/phenotype relationships. We
will organize and implement an annual Lab Hub workshop that will engage existing and potential clients in
Exposure Biology assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR
– the New York Exposome Symposium (November 2 - 3, 2018) which drew 200 scientific participants. We use
a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in
real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally
with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols
and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are
followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches
between samples and results, and integrates with the needs of the Data Center; 4) provide scientific
consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure
that feedback communication occurs between Clients and Resources/Cores and that this information is relayed
transparently to the CC and NIH and 6) ensure transparent fiscal management of the Lab Hub program.
摘要行政核心
行政核心是支配性的组织单位,并作为
西奈山非目标HHEAR实验室中心,直接与HHEAR协调中心(CC)合作,
数据中心(DC)和NIH项目人员。我们与其他实验室中心在QA/QC方面进行合作和沟通
包括能力验证和通用QC样本池、技术重复和设盲重复的程序,以及
最大限度地减少批次效应和实验室间变异性的方法,我们的团队在这些问题上发挥了关键作用。
第一个赠款周期。我们内部协调以最大限度地提高效率,并可以灵活地改变我们的优先事项
根据CC的指示。我们每周组织中心的指导委员会(SC)会议,以协调内部,
中心工作流程,包括接收样品运输、重新贴标、跟踪和进入我们的实验室
信息管理系统(LIMS)。我们组织PI/客户咨询会议,
用于设计的母研究、样本可用性、研究受试者暴露场景、健康表型,
并要求测量化学品暴露的类型。然后我们会提出最适合的建议
PI/客户的目标,同时解决可能限制可行性的任何科学或技术问题,
进行化验分析。我们还跟踪正在进行的工作的进展情况,并定期向
协调中心和NIH计划。我们与HHEAR数据中心(DC)协调数据报告,
确保我们的数据库格式正确,并包含适当的元数据。我们还与
与DC和客户/PI一起解释结果(例如,比重或样品蒸发如何
影响尿液中的代谢组学测量)和暴露/表型关系的统计分析。我们
将组织和实施年度实验室中心研讨会,让现有和潜在客户参与其中,
暴露生物学测定方法。我们是唯一一个在CHEMICAL下组织此类会议的实验室中心
- 纽约Exposome研讨会(2018年11月2日至3日)吸引了200名科学参与者。我们使用
基于Web的LIMS界面,用于通过Lab Hub系统跟踪工作进度,并评估QA/QC
分析期间的真实的时间。总之,我们1)协调实验室中心内部和外部的沟通
与协调中心、数据中心、PI/客户和NIH项目合作; 2)制定程序、方案
和系统检查,以确保样品流向正确的资源/核心,并确保QA/QC方案
3)维护用户友好的LIMS,便于样品跟踪,防止不匹配
与数据中心的需求相结合; 4)提供科学的
为PI/客户提供咨询服务,最大限度地提高其研究结果的信息和质量; 5)确保
在客户端和资源/核心之间发生反馈通信,并且该信息被中继
对CC和NIH透明,6)确保实验室中心计划的透明财务管理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Manish Arora其他文献
Manish Arora的其他文献
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{{ truncateString('Manish Arora', 18)}}的其他基金
Early Warning Systems for Childhood and Adult Disorders
儿童和成人疾病早期预警系统
- 批准号:
10382421 - 财政年份:2020
- 资助金额:
$ 18.97万 - 项目类别:
Early Warning Systems for Childhood and Adult Disorders
儿童和成人疾病早期预警系统
- 批准号:
10624212 - 财政年份:2020
- 资助金额:
$ 18.97万 - 项目类别:
Early Warning Systems for Childhood and Adult Disorders
儿童和成人疾病早期预警系统
- 批准号:
10171850 - 财政年份:2020
- 资助金额:
$ 18.97万 - 项目类别:
Early Warning Systems for Childhood and Adult Disorders
儿童和成人疾病早期预警系统
- 批准号:
9729176 - 财政年份:2020
- 资助金额:
$ 18.97万 - 项目类别:
Mount Sinai HHEAR Network Untargeted Lab Hub
西奈山 HHEAR 网络非目标实验室中心
- 批准号:
10176494 - 财政年份:2019
- 资助金额:
$ 18.97万 - 项目类别:
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