Administrative Core

摘要行政核心 行政核心是支配性的组织单位，并作为 西奈山非目标HHEAR实验室中心，直接与HHEAR协调中心（CC）合作， 数据中心（DC）和NIH项目人员。我们与其他实验室中心在QA/QC方面进行合作和沟通 包括能力验证和通用QC样本池、技术重复和设盲重复的程序，以及 最大限度地减少批次效应和实验室间变异性的方法，我们的团队在这些问题上发挥了关键作用。 第一个赠款周期。我们内部协调以最大限度地提高效率，并可以灵活地改变我们的优先事项 根据CC的指示。我们每周组织中心的指导委员会（SC）会议，以协调内部， 中心工作流程，包括接收样品运输、重新贴标、跟踪和进入我们的实验室 信息管理系统（LIMS）。我们组织PI/客户咨询会议， 用于设计的母研究、样本可用性、研究受试者暴露场景、健康表型， 并要求测量化学品暴露的类型。然后我们会提出最适合的建议 PI/客户的目标，同时解决可能限制可行性的任何科学或技术问题， 进行化验分析。我们还跟踪正在进行的工作的进展情况，并定期向 协调中心和NIH计划。我们与HHEAR数据中心（DC）协调数据报告， 确保我们的数据库格式正确，并包含适当的元数据。我们还合作 与DC和客户/PI一起解释结果（例如，比重或样品蒸发如何 影响尿液中的代谢组学测量）和暴露/表型关系的统计分析。我们 我将组织和实施一个年度实验室中心研讨会，将吸引现有和潜在的客户， 暴露生物学测定方法。我们是唯一一个在CHEMICAL下组织此类会议的实验室中心 - 纽约Exposome研讨会（2018年11月2日至3日）吸引了200名科学参与者。我们使用 基于Web的LIMS界面，用于通过Lab Hub系统跟踪工作进度，并评估QA/QC 分析期间的真实的时间。总之，我们1）协调实验室中心内部和外部的沟通 与协调中心、数据中心、PI/客户和NIH项目合作; 2）制定程序、方案 和系统检查，以确保样品流向正确的资源/核心，并确保QA/QC方案 3）维护用户友好的LIMS，便于样品跟踪，防止不匹配 与数据中心的需求相结合; 4）提供科学的 为PI/客户提供咨询服务，最大限度地提高其研究结果的信息和质量; 5）确保 在客户端和资源/核心之间发生反馈通信，并且该信息被中继 对CC和NIH透明，6）确保实验室中心计划的透明财务管理。

SUMMARY ADMINISTRATIVE CORE The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Untargeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing and common QC pools, technical replicates and blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC. We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra- Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We will then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (e.g. how specific gravity or sample evaporation may impact metabolomics measures in urine) and the statistical analysis of exposure/phenotype relationships. We will organize and implement an annual Lab Hub workshop that will engage existing and potential clients in Exposure Biology assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR – the New York Exposome Symposium (November 2 - 3, 2018) which drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Lab Hub program.