Administrative Core

摘要行政核心 行政核心是最重要的组织单位，是 西奈山非目标HHEAR实验室中心，直接与HHEAR协调中心(CC)合作， 数据中心(DC)和NIH项目人员。我们与其他实验室中心就QA/QC进行协作和沟通 包括熟练程度测试和公共QC池、技术副本和保密副本的计划，以及 将批次效应和实验室间变异性降至最低的方法，我们的团队在 CHEAR的第一个赠款周期。我们进行内部协调以最大限度地提高效率，并可以灵活地改变我们的优先事项 按照消委会的指示。我们每周组织枢纽的指导委员会(SC)会议，以协调内部 中心工作流程包括接收样品发货、重新贴标签、跟踪和进入我们的实验室 信息管理系统(LIMS)。我们组织PI/客户咨询会议，在会上我们审查 设计父母研究、样本可获得性、研究对象暴露情景、健康表型、 并要求测量化学品暴露的类型。然后，我们将提出最合适的建议 PI/客户的目标，同时解决可能限制可行性的任何科学或技术问题 进行化验分析。我们还跟踪正在进行的工作的进展情况，并定期向 协调中心和NIH项目。我们与HHEAR数据中心(DC)协调数据报告， 确保我们的数据库格式正确，并包含适当的元数据。我们还合作 在解释结果时使用DC和客户/PI(例如，比重或样品蒸发可能 影响代谢组学指标)和暴露/表型关系的统计分析。我们 将组织和实施一年一度的实验室中心研讨会，让现有和潜在客户参与 暴露生物学分析方法学。我们是唯一在CHEAR下组织这样的会议的实验室中心 -纽约展览体专题讨论会(2018年11月2日至3日)，吸引了200名科学参与者。我们用 基于Web的LIMS界面，用于通过Lab Hub系统跟踪作业进度并评估 分析过程中的实时。总而言之，我们1)协调实验室中心内部和外部的沟通 与协调中心、数据中心、PI/客户端和NIH计划；2)开发程序、协议 和系统检查，以确保样本流向正确的资源/核心，以及QA/QC协议 严格遵循；3)维护用户友好的LIMS，便于样品跟踪，防止不匹配 样品和结果之间，并与数据中心的需求相结合；4)提供科学的 为PI/客户提供咨询服务，以最大限度地提高其研究结果的信息和质量；5)确保 反馈通信发生在客户端和资源/核心之间，并且此信息被转发 对CC和NIH透明；6)确保实验室中心项目的财务管理透明。

SUMMARY ADMINISTRATIVE CORE The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Untargeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing and common QC pools, technical replicates and blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC. We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra- Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We will then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (e.g. how specific gravity or sample evaporation may impact metabolomics measures in urine) and the statistical analysis of exposure/phenotype relationships. We will organize and implement an annual Lab Hub workshop that will engage existing and potential clients in Exposure Biology assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR – the New York Exposome Symposium (November 2 - 3, 2018) which drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Lab Hub program.