The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
基本信息
- 批准号:10176597
- 负责人:
- 金额:$ 76.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-15 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAge-MonthsAnimal ModelAttentionAttention deficit hyperactivity disorderBehaviorBehavioralBirthBloodBlood CirculationBrainBuffersCaregiversChildChild Mental HealthCoupledDevelopmentDietDimensionsEnvironmentEssential Amino AcidsExposure toFetal DevelopmentGestational DiabetesGlucoseGoalsHealthcareHormonalHormonesHumanHuman DevelopmentHypertensionImpaired cognitionImpairmentIncidenceInfantInfant BehaviorInflammationInflammatoryInsulinIntakeJusticeKynurenineLearningLeptinLifeLinkMeasurementMediator of activation proteinMental disordersMetabolicMetabolic hormoneModelingNegative ValenceNeurodevelopmental DisorderNeurotransmittersNutrientNutritionalObesityOmega-3 Fatty AcidsOutcomePathway interactionsPositive ValencePregnancyProteinsPsychopathologyResearch Domain CriteriaRiskRouteSaturated Fatty AcidsSerotoninShapesSocial ProcessesSymptomsSystemTemperamentTestingTimeToddlerTranslatingTryptophanUnhealthy DietUp-RegulationValidationWorkantenatalcognitive controlcognitive systemcytokinedesignepidemiology studyexperiencefamily burdenhuman datahuman studyin uteromaternal obesitymother nutritionnegative affectnonhuman primatenovelnovel strategiesnutritionoffspringpostnatalprenatalprenatal exposurepreventprogramsprospectivesocial
项目摘要
PROJECT SUMMARY
The goal of this proposal, is to discover prenatal determinants of post-natal behavioral precursors, emerging in the first 36
months after birth, of neurodevelopmental and psychiatric disorders. Epidemiological studies have demonstrated an
association between developmental exposure to maternal obesity, gestational diabetes, and hypertension and increased
incidence of neurodevelopmental disorders; however, the mechanisms for this association remain largely unknown. Our
own work, using non-human primate models, demonstrates causal effects on offspring temperament, operating via
changes in inflammation and neurotransmitter synthesis and relate behaviorally to negative valence, supporting the
timeliness of a more focused, prospective human study to isolate potential mechanisms. From the RDoC perspective, we
therefore prioritize the negative valence domain, which our conceptual framework also places as central to developmental
risk in very early life. We also secondarily consider key modulating domains, including positive valence, social processes,
and cognitive systems. Working from a liability x experience model, and considering emerging concepts of developmental
programming, we highlight two powerful but insufficiently understood environmental inputs in early development:
maternal obesity and poor antenatal nutrition. We hypothesize that maternal obesity and poor nutrition alter the in-utero
milieu that offspring are exposed to during fetal development resulting in increased exposure to inflammatory factors.
Those, in turn, alter brain development (not directly evaluated here) and ultimately behavior (which we study carefully).
The overarching hypothesis is that increased exposure to inflammatory factors during fetal development predicts
alterations in infant negative valence, shaping a cascade of behavioral development that increases the outcomes related to
ADHD, irritability, and behavioral risk for psychiatric disorder. To address this hypothesis, a powerful yet novel
combination of a well-established infant/toddler behavioral characterization is coupled with detailed measurements of the
nutritional, metabolic, inflammatory, and hormonal profile of the in-utero environment. We also examine selected
postnatal moderators and other relevant RDoC-dimensions, in line with our model. Aim 1 evaluates the extent to which in
humans' developmental exposure to maternal obesity and/or poor maternal nutrition predicts offspring infant and toddler
behavior, in particular negative affectivity. Aim 2 examines changes in the in-utero environment induced by maternal
obesity and poor nutrition and tests the hypothesis that increased exposure to inflammation during development underlies
the behavioral changes in the offspring. Aim 3 examines the hypothesis that the programming of offspring behavior via
maternal obesity-induced inflammation is moderated by the nutrients and hormones that offspring are exposed to during
fetal development. Results will clarify mechanistic routes to psychopathology.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JOEL T NIGG', 18)}}的其他基金
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10537406 - 财政年份:2022
- 资助金额:
$ 76.05万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10320345 - 财政年份:2021
- 资助金额:
$ 76.05万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10733853 - 财政年份:2021
- 资助金额:
$ 76.05万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10095671 - 财政年份:2021
- 资助金额:
$ 76.05万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10517283 - 财政年份:2021
- 资助金额:
$ 76.05万 - 项目类别:
ADHD heterogeneity, mechanisms, and risk profile
ADHD 异质性、机制和风险状况
- 批准号:
10083596 - 财政年份:2020
- 资助金额:
$ 76.05万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
9762210 - 财政年份:2018
- 资助金额:
$ 76.05万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
10407484 - 财政年份:2018
- 资助金额:
$ 76.05万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
10700421 - 财政年份:2018
- 资助金额:
$ 76.05万 - 项目类别:
ADHD biotypes using genetic and imaging approaches
使用遗传和成像方法进行多动症生物型
- 批准号:
8706969 - 财政年份:2013
- 资助金额:
$ 76.05万 - 项目类别:
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