Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
基本信息
- 批准号:10733853
- 负责人:
- 金额:$ 7.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:3 year old3-Dimensional5 year oldAffectAffectiveAgeAge MonthsAggressive behaviorAlgorithmsAngerAreaAttention deficit hyperactivity disorderBehavioralBiologicalBiological MarkersBirthBrainBreast FeedingChildChild HealthCirculationClinicalClinical TrialsCognitionDataDepressed moodDevelopmentDevelopmental ProcessEarly DiagnosisEarly InterventionEarly identificationEducationElectroencephalographyEmotionalEnvironmental Risk FactorFetal DevelopmentFormulationFrightFunctional disorderFutureGeneticGoalsHandHealthcareImpairmentImpulsivityIndividualInfantInflammationInflammatoryInterceptInterventionIntervention TrialJusticeKynurenineLearningLifeLiteratureMagnetic Resonance ImagingMeasurableMeasuresMediatingMental HealthModelingNursery SchoolsOutcomeParentsPathway interactionsPhenotypePhysiologicalPregnancyPregnancy TrimestersPreschool ChildProgram DevelopmentPsychopathologyRegulationRiskRisk FactorsRisk MarkerRoleSchool-Age PopulationSchoolsSecond Pregnancy TrimesterSerotoninShapesSignal TransductionSocializationSymptomsSystemTestingThird Pregnancy TrimesterTimeToddlerTryptophanUp-RegulationWeatherWomanWorkbehavioral outcomecaregivingclinical applicationclinical candidateclinical riskcohortcostearly childhoodemotion dysregulationemotion regulationexecutive functionexperimental studyfamily burdenfetalfollow-upinattentionindexinginterestnegative affectneuralneurodevelopmentoffspringpostnatalprenatalpreventprospectiverisk predictionsoundsystemic inflammatory responseteacher
项目摘要
PROJECT SUMMARY:
The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral and
emotional problems. To do so children are followed from before birth to 4.5 years of age—on the cusp of school entry and
well into the preschool period. ADHD and related problems with behavioral and emotional dysregulation are often not
clinically identified until school age. By that point they are difficult to reverse. This proposal answers calls in the literature
for earlier identification of risk and for discovery of early life mechanisms that can be targets for low-risk yet effective
early life intervention to prevent the full onset of these problems. To do so we expand the study of an existing maternal-
infant cohort by adding measures, time points, and an older outcome. We extend the cohort from the toddler years into the
preschool period when psychopathology has begun to take shape and be able to be relatively reliably characterized. Key
mechanisms to be examined are (a) biological signals in early life, focused on maternal inflammation and serotonergic
metabolites during pregnancy and the trajectory of change in those signals in the first three years of life; (b) brain
development as indexed by EEG measures from birth to age 3 years (lower cost and more readily clinically applicable
than MRI at this stage); and (c) behavioral dynamics in early caregiving, about which little is known regarding ADHD
risk in the first 24 months of life. The inflammation hypothesis builds on striking preliminary data uncovered by the PI's
in their prior work. The EEG metrics likewise are supported by preliminary evidence. The behavioral data also have
strong preliminary data and build on multiple theorists' proposals about the role of early emotional regulation in
subsequent risk for dysregulatory psychopathology and ADHD. Both baseline (intercept) and change (trajectory)
measures will be examined to help evaluate when in development a particular domain or level of analysis is most
informative to subsequent outcome. Each of these hypotheses is examined in stand-alone fashion, and then with those
findings in hand, an integrative developmental model will be tested. If successful the study will open new directions for
low-risk yet potentially effective early intervention by identifying specific, measurable, and reversible risk factors or
mechanisms as candidates for clinical trial follow up.
项目总结:
项目成果
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{{ truncateString('JOEL T NIGG', 18)}}的其他基金
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10537406 - 财政年份:2022
- 资助金额:
$ 7.51万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10320345 - 财政年份:2021
- 资助金额:
$ 7.51万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10095671 - 财政年份:2021
- 资助金额:
$ 7.51万 - 项目类别:
Developmental origins and early detection of ADHD and dysregulatory psychopathology
ADHD 和失调性精神病理学的发育起源和早期发现
- 批准号:
10517283 - 财政年份:2021
- 资助金额:
$ 7.51万 - 项目类别:
ADHD heterogeneity, mechanisms, and risk profile
ADHD 异质性、机制和风险状况
- 批准号:
10083596 - 财政年份:2020
- 资助金额:
$ 7.51万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
10176597 - 财政年份:2018
- 资助金额:
$ 7.51万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
9762210 - 财政年份:2018
- 资助金额:
$ 7.51万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
10407484 - 财政年份:2018
- 资助金额:
$ 7.51万 - 项目类别:
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental Disorders
母亲肥胖和产前营养不良对后代 RDoC 维度和神经发育障碍风险的影响
- 批准号:
10700421 - 财政年份:2018
- 资助金额:
$ 7.51万 - 项目类别:
ADHD biotypes using genetic and imaging approaches
使用遗传和成像方法进行多动症生物型
- 批准号:
8706969 - 财政年份:2013
- 资助金额:
$ 7.51万 - 项目类别:
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