ADHD heterogeneity, mechanisms, and risk profile

ADHD 异质性、机制和风险状况

• 批准号: 10083596
• 负责人: JOEL T NIGG
• 金额: $ 11.14万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-17 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10083596
• 关键词: 19 year old; Affect; Algorithms; Attention deficit hyperactivity disorder; Caring; Characteristics; Child; Clinical; Data; Development; Developmental Course; Emotional; Family; Heterogeneity; Impairment; Informal Social Control; Instruction; Intervention; Knowledge; Longitudinal Studies; Longterm Follow-up; Measures; Outcome; Population; Public Health; Quality of life; Risk; Schools; Syndrome; Translating; advanced analytics; clinical care; clinical decision-making; clinical practice; clinical predictors; clinical translation; cognitive control; computerized tools; emotion regulation; follow-up; improved; next generation

ADHD remains a serious public health concern particularly in relation to long-term outcome, with recent follow up data from other projects, such as the MTA study, suggesting that current assessment and sustained treatment practices do not much alter clinical course. In addition, societal and clinical concerns remain about mis-identification of children with ADHD who need care, because some children seem to improve developmentally, while others have poor outcomes. While a great deal is known about the correlates of developmental course, little of this knowledge has translated to clinical practice, and in particular to clinical prediction—essentially, deciding whether a child, presenting with ADHD, requires intervention or for whom a clinician can afford to wait and observed. We have previously made progress here by re-conceptualizing ADHD as a problem in self-regulation involving cognitive control as well as emotion regulation and emotionality. This has helped us find new and valid sub-profiles that are clinically predictive. We follow that up here and add new effort to use advanced computational tools to predict clinical course over a developmental period from 7-19 years of age, using a range of measures at different levels of analysis, and thus to develop algorithms that could point the way toward next-generation clinical translation from longitudinal studies. RELEVANCE (See instructions): ADHD continues to be a serious and impairing syndrome for millions of children, affecting families, schools, and life quality. While a great deal is known about the correlates of ADHD, this information has not translated sufficiently into more efficient clinical decision-making that recognizes the variety of children within this population. This project seeks to use advanced analytics and long-term follow up data to identify better ways to identify groups of children with ADHD with characteristic profiles to improve clinical care.

多动症仍然是一个严重的公共卫生问题，特别是与长期结果有关