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Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathy

基于超广角光学相干断层扫描的血管造影用于糖尿病视网膜病变成像

基本信息

批准号：
10176506
负责人：
Ruikang Wang
金额：
$ 55.89万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10176506
关键词：
3-Dimensional Acute Adult Affect Aging American Anaphylaxis Angiography Anterior Architecture Blood Vessels Blood capillaries Blood flow Characteristics Choroid Chronic Clinical Color Communities Contrast Media Coupled Data Development Diabetes Mellitus Diabetic Retinopathy Diagnosis Disease Doppler Ultrasound Dyes Ensure Evaluation Eye diseases Fluorescein Angiography Fluorescence Angiography Foundations Fundus photography Future Goals Human Image Imaging Device Imaging Techniques Imaging technology Incidence Indocyanine Green Injections Knowledge Label Laser-Doppler Velocimetry Lasers Measures Methods Microcirculation Microfluidics Monitor Morphology Neural Retina Optical Coherence Tomography Optics Outcomes Research Pathology Patients Perfusion Peripheral Phase Photography Physicians Physiology Population Posterior eyeball segment structure Preventive Pupil Research Resolution Retina Retinal Diseases Rheology Risk Scanning Site Source Speed Structure System Techniques Testing Therapeutic Therapeutic Intervention Thick Three-Dimensional Image Three-Dimensional Imaging Tissues Translating Trees Vascular Diseases Vision Visualization base blood perfusion clinical application clinical imaging design design and construction diabetes management feasibility testing fundus imaging human imaging imaging modality imaging study imaging system improved in vivo in vivo imaging macula microangiography next generation non-invasive imaging novel optical imaging perfusion imaging peripheral blood vessel prototype retinal imaging screening targeted treatment three-dimensional visualization tool two-dimensional

项目摘要

Project Summary The increasing incidence of diabetes in the US population and the inertial wave of aging in Americans will ensure that diabetic retinopathy (DR) remains one of the principal threats to the sight of adult patients and a significant management challenge for the clinical community. It is now clear that the peripheral retina is the site of pathology in many vision-threatening eye diseases, including DR. Evaluation of the retinal periphery, therefore, is important for screening, diagnosis, monitoring, and treatment of disease manifestations. Historically, imaging of the peripheral retina has been limited and difficult to obtain; recent advancements in wide-field photography, however, have dramatically improved the ability to image the anterior retina. To reveal vascular involvements in the peripheral retina, invasive imaging techniques, e.g., fluorescein angiography (FA) and indo-cyanine green angiography (ICGA), are currently used. Both techniques have traditionally been utilized to make diagnoses and treatment decisions, but they only provide two-dimensional (2D) images and require intravascular injections that risk complications. It would be highly advantageous to be capable of 3D visualization of peripheral vascular perfusion with capillary-level resolution, both to reveal the detailed functional architecture of the microvascular network and to permit quantification of the perfusion status of the retina. This information would be fundamental to better understanding of retinal diseases that has peripheral vascular involvements, e.g. DR, resulting in more informed and targeted treatment decisions. In this project, we propose to develop a clinically applicable 3D ultra widefield optical microangiography (UW-OMAG) system capable of imaging the neural retina at ~180-degree field of view. We envision that this novel, non-invasive, and label-free optical imaging method will quantify the morphology of blood vessels and permit assessment of their spatial relations in 3D, not only in the central macular region, but in the peripheral retina. Concurrently, total retinal blood flow (RBF) and vascular volumes of the retina can be quantitatively assessed. To achieve this goal, we will first design and construct a novel, UW-OMAG system based on swept source optical coherence tomography capable of 400 kHz A-scan rate. The focus will be on solving challenges associated with creating an UW-OMAG retinal imaging system that is capable of providing an imaging range of >12mm with minimal system sensitivity roll-off characteristics so that it is able to adapt and image the curved posterior segment, and achieving an unprecedented imaging field of view ~180o. We will then utilize this clinically applicable prototype to validate its accuracy for visualizing the peripheral retinal microvasculature, compared to ultra widefield fundus photography and FA. Finally, we will perform UW-OMAG pilot imaging studies in 160 subjects of normal and DR subjects to demonstrate clinical feasibility and usefulness of this new label-free 3D ultra widefield microangiography of vascular structure and function. This study will serve as the foundation for next generation of OCT angiography and for interpretation of UW-OMAG data in future.

项目总结

项目成果

期刊论文数量（49）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy.

DOI：
10.1186/s40662-018-0113-2
发表时间：
2018
期刊：
Eye and vision (London, England)
影响因子：
0
作者：
Wang F;Zhang Q;Deegan AJ;Chang J;Wang RK
通讯作者：
Wang RK

Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma.

DOI：
10.1016/j.ajo.2021.05.012
发表时间：
2021-11
期刊：
American journal of ophthalmology
影响因子：
4.2
作者：
Phillips MJ;Dinh-Dang D;Bolo K;Burkemper B;Lee JC;LeTran VH;Chang BR;Grisafe DJ;Chu Z;Zhou X;Song BJ;Xu BY;Wong B;Wang RK;Richter GM
通讯作者：
Richter GM

Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study.

DOI：
10.1371/journal.pone.0243830
发表时间：
2020
期刊：
PloS one
影响因子：
3.7
作者：
Dai Y;Zhou H;Zhang Q;Chu Z;Olmos de Koo LC;Chao JR;Rezaei KA;Saraf SS;Wang RK
通讯作者：
Wang RK

Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography.