Columbia University/Aga Khan University Global Network Research Unit

哥伦比亚大学/阿迦汗大学全球网络研究中心

• 批准号: 10176542
• 负责人: ROBERT L GOLDENBERG
• 金额: $ 60.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176542
• 关键词: Adoption; Adrenal Cortex Hormones; Aspirin; Child; Child Health; Cluster randomized trial; Collaborations; Communities; Community Health; Country; Data; Dedications; Development; Discipline of obstetrics; Dose; Enrollment; Environment; Fetal Mortality Statistics; Funding; Future; Goals; Government; Growth and Development function; Gynecology; Health Sciences; Health system; Hospitals; International; Intervention; Intervention Trial; Leadership; Maternal Mortality; Maternal and Child Health; Measures; Mentors; Morbidity - disease rate; Multicenter Trials; Neonatal Mortality; Newborn Infant; Outcome; Pakistan; Participant; Population-Based Registry; Pregnancy; Pregnant Women; Premature Birth; Prenatal care; Protocols documentation; Provider; Public Health Practice; Publications; Recording of previous events; Registries; Research; Research Personnel; Research Support; Resources; Risk Factors; Rural Population; Senior Scientist; Services; Site; Training; Ultrasonography; Universities; Urban Population; Woman; Women' s Health; adverse pregnancy outcome; base; cost effective intervention; data quality; fetal; follow-up; improved; insight; low and middle-income countries; low income country; meetings; member; mortality; multidisciplinary; neonatal resuscitation; pregnancy health; protocol development; randomized trial; recruit; trend

Project Summary: The Aga Khan University/Columbia University (AKU/CU) Global Network Research Unit is applying to continue its membership in the Global Network for Women's and Children's Health Research (Global Network [GN]). At CU, the project is located in the Dept. of OBGYN and at AKU within the Dept. of Community Health Sciences (CHS). To date, our site has been among the most productive in the GN. We have fully participated in all aspects of the GN from developing successful concepts for single site and common protocols to leadership on GN committees. We have acquired non-GN funds both to support GN multisite projects and to strengthen the Dept. of CHS at AKU. We have proven access to large urban and rural populations and have successfully performed hospital-based and community-based studies. We are the only site to have participated in every common protocol. We have contributed more clusters to the GN Registry and cluster-randomized trials than any other site. Our follow-up rates and the quality of our data are excellent. Over the 17 years in the GN, we have enrolled more than 230,000 women and children in GN projects. In the next 5 years, we plan to continue or surpass this level of engagement as detailed below. As part of the GN, we will conduct multi-center trials of interventions for pregnant women, newborns and children to reduce their mortality and morbidity in Pakistan and other low- resource countries. We also plan to continue to maintain a population-based registry of pregnancies and their outcomes in Pakistan, to measure trends and factors associated with those outcomes and to compare risk factors and outcomes to other GN sites. We will continue being a leader among the GN sites in protocol development, subject recruitment, data quality and obtaining outside funding for GN projects and continue to stimulate the development of Pakistani researchers and promote collaborations between AKU researchers and those from CU and other US sites. We will continue to attract new Pakistani and US investigators to global maternal and child health research by systematic mentoring of junior investigators and recruiting senior scientists from related fields, and to continue enhancing the research environment at AKU by providing high-quality administrative, financial, statistical and research support services within a scientifically stimulating multidisciplinary setting. We also will continue to support government endeavors to strengthen the health system in our research site by facilitating training on new cost-effective interventions suitable for countries with limited resources. Because of the many strengths of our research team and its dedication to improving the health of women and children in low-resource settings, as well as its long history of collaboration within the GN and with many entities in Pakistan, we strongly believe that the goals described above will be achieved almost immediately and continue indefinitely, and that the AKU/CU site will continue to be a leader in the GN. As a member of the GN, the AKU/CU site will continue to participate in all aspects of the GN including meeting participation, membership in committees, seeking outside funding, initiating new projects, participating in all studies and using GN data to produce important publications.

项目概要： 阿加汗大学/哥伦比亚大学（AKU/CU）全球网络研究单位正在申请继续 全球妇女和儿童健康研究网络（Global Network for Women's and Children's Health Research，简称GN）。在 CU，该项目位于部门。在妇产科和AKU部门内。社区健康科学 （CHS）.迄今为止，我们的网站一直是GN中最具生产力的网站之一。我们全面参与了各个方面 从为单个站点和通用协议开发成功的概念，到在GN上发挥领导作用， 委员会。我们已经获得了非GN资金，以支持GN多站点项目和加强部门。 在AKU。我们已经证明可以接触到大量的城市和农村人口， 以医院为基础和以社区为基础的研究。我们是唯一一个参加过所有 议定书我们为GN注册和随机分组试验提供的分组数量比其他任何研究都多 绝佳的价钱我们的随访率和数据质量都很好。在GN的17年里，我们招收了 超过23万名妇女和儿童参与了GN项目。在未来5年，我们计划继续或超越这一点 参与程度详见下文。作为GN的一部分，我们将进行多中心干预试验， 巴基斯坦和其他低收入国家的孕妇、新生儿和儿童的死亡率和发病率， 资源国。我们还计划继续维持一个以人口为基础的怀孕登记册， 巴基斯坦的结果，衡量与这些结果相关的趋势和因素，并比较风险因素， 以及其他GN地点的结果。我们将继续成为GN研究中心在协议开发方面的领导者， 受试者招募，数据质量和获得GN项目的外部资金，并继续刺激 发展巴基斯坦研究人员，促进AKU研究人员与CU研究人员之间的合作 其他美国网站。我们将继续吸引新的巴基斯坦和美国调查人员到全球母婴 通过对初级研究人员的系统指导和从相关领域招募高级科学家进行健康研究， 并通过提供高质量的行政，财务， 在科学激励的多学科环境中提供统计和研究支助服务。我们也将 继续支持政府努力加强我们研究地点的卫生系统， 培训适合资源有限国家的新的成本效益高的干预措施。由于许多 我们的研究团队的优势及其致力于改善低资源地区妇女和儿童的健康， 环境，以及其在GN内部和与巴基斯坦许多实体的长期合作历史，我们强烈 我相信上述目标将几乎立即实现，并将无限期地持续下去， AKU/CU站点将继续在GN中处于领先地位。作为GN的成员，AKU/CU网站将继续 参与GN的各个方面，包括参加会议，委员会成员，寻求外部 资助，启动新项目，参与所有研究，并使用全球网络数据制作重要出版物。