Columbia University/Aga Khan University Global Network Research Unit

描述（由申请人提供）：本申请的全球网络（GN）的妇女和儿童的研究要求全球网络研究单位的阿加汗和哥伦比亚大学要更新为第三个5年任期。我们相信，我们的业绩记录，特别是在过去5年中，在完整的应用程序中记录，证明了该奖项的合理性。 未来5年。该应用程序的优势包括一个稳定和高效的团队，致力于开展有意义的研究，以改善妇女和儿童的健康，大量和不同的研究人口，以及每年500次分娩的20个农村集群的正在进行的出生结果登记，每个集群都有很好的后续行动。巴基斯坦拥有1.8亿人口，是世界上孕产妇、胎儿和新生儿死亡率最高的国家之一，提供了可以考虑进行GN研究的各种人群。我们拥有最多的农村集群的任何网站在GN与活跃的出生登记，并在每个还显示了访问一些城市医院分娩和访问城市儿童的研究目的。迄今为止，我们已经招募了超过220，000名受试者进行GN研究。在接下来的5年里，我们计划通过在行业，基金会和GN之间建立牢固的关系，为GN带来大量的外部资源，以便对所有三个机构都有意义。我们将积极参与审议， GN指导委员会，并继续指导更多的初级研究人员在我们的网站和其他网站在GN的研究设计，手稿和赠款准备。我们的主要目标之一是改善母婴护理设施的性能。我们提出的共同协议有助于减少设施胎儿和新生儿死亡率，使用与设施护理相关的定义结果，例如，产时死产和早期（出院前）新生儿死亡的总和。使用一个简单的蜂窝电话为基础的数据收集系统，快速反馈的定义的结果，和一个质量保证计划，旨在减少产时相关的死亡，这是我们希望实现一个大幅度改善设施为基础的妊娠结局。

DESCRIPTION (provided by applicant): This application to the Global Network (GN) for Women's and Children's Research asks for the Global Network Research Unit of Aga Khan and Columbia Universities to be renewed for a third 5 year term. We believe that our track record, especially over the last 5 years, as documented in the full application, justifies an award for the next 5 years. The strengths of this application include a stable and highly productive team devoted to carrying out meaningful research to improve the health of women and children, large and varied populations for study, and an ongoing birth outcomes registry of 20 rural clusters of 500 deliveries per year each with excellent follow up. Pakistan, with a population of 180,000,000 people and some of the highest maternal, fetal and neonatal mortality rates anywhere in the world, provides every type of population that could be considered for GN studies. We have the largest number of rural clusters of any site in the GN with an active birth registry in each, and have also demonstrated access to a number of urban hospitals for deliveries and access to urban children for research purposes as well. To date we have recruited more than 220,000 subjects for GN studies. In the next 5 years, we plan to bring substantial external resources to the GN by building strong relationships between industry, foundations and the GN to do research meaningful to all three institutions. We will actively participate in the deliberations of the GN Steering Committee and continue to mentor more junior investigators at our site and other sites in the GN in research study design, and manuscript and grant preparation. One of our major goals is to improve facility performance in the care of mothers and infants. Our proposed common protocol alms to reduce facility fetal and neonatal mortality using a defined outcome related to facility care, e.g., the sum of intrapartum stillbirths and early (pre- discharg) neonatal deaths. Using a simple cellular telephone-based data collection system, rapid feedback on the defined outcome, and a quality assurance program aimed at reducing intrapartum related deaths; it is our hope to achieve a substantial improvement in facility-based pregnancy outcomes.