Columbia University/Aga Khan University Global Network Research Unit

描述(由申请人提供)：向全球妇女和儿童研究网络(GN)提交的这份申请要求阿加汗大学和哥伦比亚大学的全球网络研究单位续签第三个5年任期。我们相信，我们的业绩记录，特别是过去5年的记录，如在完整的申请中记录的那样，证明有理由为 接下来的5年。这一应用程序的优势包括：一支稳定和高效的团队，致力于开展有意义的研究，以改善妇女和儿童的健康；研究人群众多，种类繁多；正在进行的20个农村分组的生育结果登记，每个分组每年500次分娩，并有出色的后续行动。巴基斯坦拥有1.8亿人口，是世界上孕产妇、胎儿和新生儿死亡率最高的国家之一，它提供了可以考虑用于GN研究的各种类型的人口。在GN的所有地点中，我们拥有最多的农村联网，每个地点都有活跃的出生登记，还证明了可以进入一些城市医院分娩，也可以出于研究目的接触城市儿童。到目前为止，我们已经为GN研究招募了超过22万名受试者。在接下来的5年里，我们计划通过在行业、基金会和GN之间建立牢固的关系，为GN带来大量的外部资源，以进行对这三个机构都有意义的研究。我们将积极参与审议工作。 GN指导委员会并继续在我们的站点和GN的其他站点指导更多初级调查人员在研究研究设计、手稿和赠款准备方面的工作。我们的主要目标之一是提高母婴护理设施的绩效。我们建议的共同方案是使用与设施护理相关的定义结果来降低设施胎儿和新生儿死亡率，例如，产中死胎和早期(出院前)新生儿死亡的总和。使用简单的基于移动电话的数据收集系统，对定义的结局进行快速反馈，以及旨在减少与分娩相关的死亡的质量保证计划；我们希望在基于设施的妊娠结局方面实现实质性改善。

DESCRIPTION (provided by applicant): This application to the Global Network (GN) for Women's and Children's Research asks for the Global Network Research Unit of Aga Khan and Columbia Universities to be renewed for a third 5 year term. We believe that our track record, especially over the last 5 years, as documented in the full application, justifies an award for the next 5 years. The strengths of this application include a stable and highly productive team devoted to carrying out meaningful research to improve the health of women and children, large and varied populations for study, and an ongoing birth outcomes registry of 20 rural clusters of 500 deliveries per year each with excellent follow up. Pakistan, with a population of 180,000,000 people and some of the highest maternal, fetal and neonatal mortality rates anywhere in the world, provides every type of population that could be considered for GN studies. We have the largest number of rural clusters of any site in the GN with an active birth registry in each, and have also demonstrated access to a number of urban hospitals for deliveries and access to urban children for research purposes as well. To date we have recruited more than 220,000 subjects for GN studies. In the next 5 years, we plan to bring substantial external resources to the GN by building strong relationships between industry, foundations and the GN to do research meaningful to all three institutions. We will actively participate in the deliberations of the GN Steering Committee and continue to mentor more junior investigators at our site and other sites in the GN in research study design, and manuscript and grant preparation. One of our major goals is to improve facility performance in the care of mothers and infants. Our proposed common protocol alms to reduce facility fetal and neonatal mortality using a defined outcome related to facility care, e.g., the sum of intrapartum stillbirths and early (pre- discharg) neonatal deaths. Using a simple cellular telephone-based data collection system, rapid feedback on the defined outcome, and a quality assurance program aimed at reducing intrapartum related deaths; it is our hope to achieve a substantial improvement in facility-based pregnancy outcomes.