Columbia University/Aga Khan University Global Network Research Unit

哥伦比亚大学/阿迦汗大学全球网络研究中心

• 批准号: 10614172
• 负责人: ROBERT L GOLDENBERG
• 金额: $ 60.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614172
• 关键词: Adoption; Adrenal Cortex Hormones; Aspirin; Child; Child Health; Cluster randomized trial; Collaborations; Communities; Community Health; Country; Data; Dedications; Development; Discipline of obstetrics; Dose; Enrollment; Environment; Fetal Mortality Statistics; Funding; Future; Goals; Government; Growth and Development function; Gynecology; Health Sciences; Health system; Hospitals; International; Intervention; Intervention Trial; Leadership; Maternal Mortality; Maternal and Child Health; Measures; Mentors; Morbidity - disease rate; Multicenter Trials; Neonatal Mortality; Newborn Infant; Outcome; Pakistan; Participant; Population-Based Registry; Pregnancy; Pregnant Women; Premature Birth; Prenatal care; Protocols documentation; Provider; Public Health Practice; Publications; Recording of previous events; Registries; Research; Research Personnel; Research Support; Resource-limited setting; Resources; Risk Factors; Rural Population; Senior Scientist; Services; Site; Training; Universities; Urban Population; Woman; Women' s Health; adverse pregnancy outcome; base; cost effective intervention; data quality; fetal; follow-up; improved; insight; low and middle-income countries; low income country; meetings; member; mortality; multidisciplinary; neonatal resuscitation; pregnancy health; protocol development; randomized trial; recruit; trend; ultrasound

Project Summary: The Aga Khan University/Columbia University (AKU/CU) Global Network Research Unit is applying to continue its membership in the Global Network for Women's and Children's Health Research (Global Network [GN]). At CU, the project is located in the Dept. of OBGYN and at AKU within the Dept. of Community Health Sciences (CHS). To date, our site has been among the most productive in the GN. We have fully participated in all aspects of the GN from developing successful concepts for single site and common protocols to leadership on GN committees. We have acquired non-GN funds both to support GN multisite projects and to strengthen the Dept. of CHS at AKU. We have proven access to large urban and rural populations and have successfully performed hospital-based and community-based studies. We are the only site to have participated in every common protocol. We have contributed more clusters to the GN Registry and cluster-randomized trials than any other site. Our follow-up rates and the quality of our data are excellent. Over the 17 years in the GN, we have enrolled more than 230,000 women and children in GN projects. In the next 5 years, we plan to continue or surpass this level of engagement as detailed below. As part of the GN, we will conduct multi-center trials of interventions for pregnant women, newborns and children to reduce their mortality and morbidity in Pakistan and other low- resource countries. We also plan to continue to maintain a population-based registry of pregnancies and their outcomes in Pakistan, to measure trends and factors associated with those outcomes and to compare risk factors and outcomes to other GN sites. We will continue being a leader among the GN sites in protocol development, subject recruitment, data quality and obtaining outside funding for GN projects and continue to stimulate the development of Pakistani researchers and promote collaborations between AKU researchers and those from CU and other US sites. We will continue to attract new Pakistani and US investigators to global maternal and child health research by systematic mentoring of junior investigators and recruiting senior scientists from related fields, and to continue enhancing the research environment at AKU by providing high-quality administrative, financial, statistical and research support services within a scientifically stimulating multidisciplinary setting. We also will continue to support government endeavors to strengthen the health system in our research site by facilitating training on new cost-effective interventions suitable for countries with limited resources. Because of the many strengths of our research team and its dedication to improving the health of women and children in low-resource settings, as well as its long history of collaboration within the GN and with many entities in Pakistan, we strongly believe that the goals described above will be achieved almost immediately and continue indefinitely, and that the AKU/CU site will continue to be a leader in the GN. As a member of the GN, the AKU/CU site will continue to participate in all aspects of the GN including meeting participation, membership in committees, seeking outside funding, initiating new projects, participating in all studies and using GN data to produce important publications.

项目总结： 阿加汗大学/哥伦比亚大学(AKU/CU)全球网络研究股正在申请继续 它是全球妇女儿童健康研究网络(全球网络[GN])的成员。在… 中大，该项目位于中科院系。OBGYN和AKU在系内社区健康科学系 (CHS)。到目前为止，我们的网站一直是GN中生产率最高的网站之一。我们在各个方面都充分参与了 从开发单一站点和通用协议的成功概念到在GN上的领导地位 委员会。我们已经获得了非GN资金，用于支持GN多站点项目和加强该部。 在AKU的CHS。我们已经证明可以接触到大量的城市和农村人口，并成功地执行了 以医院和社区为基础的研究。我们是唯一一个参与过每一次 协议。我们为GN注册和集群随机试验贡献了比任何其他试验更多的集群 地点。我们的随访率和数据质量都很好。在GN的17年里，我们已经招收了 GN项目中有230,000多名妇女和儿童。在未来5年，我们计划继续或超越这一点 参与度如下所示。作为GN的一部分，我们将对以下干预措施进行多中心试验 在巴基斯坦和其他低收入国家，孕妇、新生儿和儿童将降低死亡率和发病率 资源国。我们还计划继续维持以人口为基础的怀孕登记和他们的 巴基斯坦的结果，以衡量与这些结果相关的趋势和因素，并比较风险因素 以及对其他GN站点的影响。我们将继续保持GN网站在协议开发方面的领先地位， GN项目的科目招聘、数据质量和获得外部资金，并继续刺激 发展巴基斯坦研究人员，促进AKU研究人员与CU研究人员之间的合作 和其他美国网站。我们将继续吸引新的巴基斯坦和美国调查人员前往全球母婴 通过系统地指导初级研究人员和从相关领域招募资深科学家进行卫生研究， 并继续改善AKU的研究环境，提供高质量的行政、财务、 在科学刺激的多学科背景下提供统计和研究支持服务。我们也会 继续支持政府加强我们研究站点的卫生系统的努力，通过促进 培训适用于资源有限国家的新的成本效益高的干预措施。因为有很多人 我们研究团队的优势及其致力于改善低资源地区妇女和儿童的健康 环境，以及其在GN内部以及与巴基斯坦许多实体的长期合作历史，我们强烈 相信上述目标将几乎立即实现并无限期地持续下去 AKU/CU网站将继续在GN中处于领先地位。作为GN的成员，AKU/CU网站将继续 参与GN的方方面面，包括会议参与、委员会成员、寻求外部 资助、启动新项目、参与所有研究并使用全球网络数据制作重要出版物。