1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core

1佛罗里达阿尔茨海默病研究中心数据管理和统计 (DMS) 核心

• 批准号: 9921604
• 负责人: MICHAEL MARSISKE
• 金额: $ 34.1万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9921604
• 关键词: Algorithms; Alzheimer' s Disease; Big Data; Biological Markers; Biometry; Catalogs; Clinical; Clinical Trials; Code; Collaborations; Communities; Competence; Computer software; Consultations; Data; Data Analyses; Data Collection; Data Management Resources; Data Security; Data Set; Database Management Systems; Dementia; Development; Diagnosis; Documentation; Ensure; Equation; Equipment and supply inventories; Fiber; Florida; Geography; Growth; Language; Leadership; Link; Logistic Regressions; Maintenance; Manuscripts; Measures; Methods; Modeling; Participant; Peer Review; Process; Publications; Pythons; Quality Control; Reproducibility; Research; Research Design; Research Personnel; Research Support; Secure; Source Code; Statistical Data Interpretation; Statistical Methods; Structure; System; Training Activity; Trust; Validation; Work; biomedical informatics; career; data acquisition; data collection site; data exchange; data management; data warehouse; distributed data; eHealth; education research; longitudinal analysis; machine learning algorithm; multilevel analysis; neuroimaging; novel; open data; open source; operation; phenotypic data; power analysis; repository; sound; statistics; tool

Summary/Abstract: Data Management and Statistical Core, 1Florida ADRC The Data Management and Statistical Core of the 1Florida ADRC functions as key connective fiber that links the various cores of the center, provides the principal point of contact with internal and external investigators and trainees, and is the primary conduit to the National Alzheimer’s Coordinating Center (NACC), both for the delivery of data, and for the acquisition of data sets for local investigators. The Core also exists to ensure rigor and reproducibility at every step of data handling, from entry and coding, through analysis and dissemination. Consistent with the central themes of the 1Florida ADRC, the Core (a) consolidates, de-identifies and provides biomarker data to investigators, (b) puts particular emphasis on data analysis methods for longitudinal analysis, particularly in supporting and educating early career investigators in their use, (c) supports biomedical informatics and e-health investigators in accessing and using large data repositories (e.g., the One Florida Data Trust) for development of novel hypotheses regarding dementias. The core also provides leadership in the collaborative development of open source applications for the coding and transmission of data. Aims of the Core include: (1) providing high quality data management processes and systems to data that has been validated, integrated/merged (across Center operations), is secure, well documented, and shared with other investigators locally and nationally; (2) providing up-to-date data analysis consultation in a) study design, b) selection of study measures, c) data analysis, d) interpretation of findings, and e) presentation, before, during and after data collection and analysis. The core also ensures rigor and reproducibility of 1Florida ADRC research by supporting (a) pre-registration of manuscripts, (b) use of reproducible and open source code for data analyses, (c) use of preprint publication of manuscripts for wide dissemination and “open peer review”. (3) supporting the larger community of ADRC investigators nationally, and those affiliated with the 1Florida ADRC, with open source data management tools and applications; as well as with 42 online training modules (with practice data sets and code), via the Research Education Component, in methods ranging from simple descriptive to advance growth and survival models.

摘要/摘要：数据管理与统计核心，1Florida ADRC