1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core
1佛罗里达阿尔茨海默病研究中心数据管理和统计 (DMS) 核心
基本信息
- 批准号:10413192
- 负责人:
- 金额:$ 42.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AlgorithmsAlzheimer&aposs DiseaseBig DataBiological MarkersBiometryCatalogsClinicalClinical TrialsCodeCollaborationsCommunitiesCompetenceComputer softwareConsultationsDataData AnalysesData CollectionData Management ResourcesData SecurityData SetDatabase Management SystemsDementiaDevelopmentDiagnosisDocumentationEnsureEquationEquipment and supply inventoriesFiberFloridaGeographyGrowthLanguageLeadershipLinkLogistic RegressionsMaintenanceManuscriptsMeasuresMethodsModelingParticipantPeer ReviewProcessPublicationsPythonsQuality ControlReproducibilityResearchResearch DesignResearch PersonnelResearch SupportSecureSource CodeStatistical Data InterpretationStatistical MethodsSystemTraining ActivityTrustValidationWorkbiomedical informaticscareerdata acquisitiondata collection sitedata exchangedata handlingdata managementdata repositorydistributed dataeHealtheducation researchlongitudinal analysismachine learning algorithmmultilevel analysisneuroimagingnovelopen dataopen sourceoperationphenotypic datapower analysisrepositorysoundstatisticstool
项目摘要
Summary/Abstract: Data Management and Statistical Core, 1Florida ADRC
The Data Management and Statistical Core of the 1Florida ADRC functions as key connective fiber that links
the various cores of the center, provides the principal point of contact with internal and external investigators and
trainees, and is the primary conduit to the National Alzheimer’s Coordinating Center (NACC), both for the delivery
of data, and for the acquisition of data sets for local investigators. The Core also exists to ensure rigor and
reproducibility at every step of data handling, from entry and coding, through analysis and dissemination.
Consistent with the central themes of the 1Florida ADRC, the Core (a) consolidates, de-identifies and provides
biomarker data to investigators, (b) puts particular emphasis on data analysis methods for longitudinal analysis,
particularly in supporting and educating early career investigators in their use, (c) supports biomedical informatics
and e-health investigators in accessing and using large data repositories (e.g., the One Florida Data Trust) for
development of novel hypotheses regarding dementias. The core also provides leadership in the collaborative
development of open source applications for the coding and transmission of data. Aims of the Core include:
(1) providing high quality data management processes and systems to data that has been validated,
integrated/merged (across Center operations), is secure, well documented, and shared with other investigators
locally and nationally;
(2) providing up-to-date data analysis consultation in a) study design, b) selection of study measures, c) data
analysis, d) interpretation of findings, and e) presentation, before, during and after data collection and analysis.
The core also ensures rigor and reproducibility of 1Florida ADRC research by supporting (a) pre-registration of
manuscripts, (b) use of reproducible and open source code for data analyses, (c) use of preprint publication of
manuscripts for wide dissemination and “open peer review”.
(3) supporting the larger community of ADRC investigators nationally, and those affiliated with the 1Florida
ADRC, with open source data management tools and applications; as well as with
42 online training modules (with practice data sets and code), via the Research Education Component, in
methods ranging from simple descriptive to advance growth and survival models.
摘要/摘要:数据管理和统计核心,1佛罗里达州ADRC
1佛罗里达ADRC的数据管理和统计核心是连接
该中心的各个核心,提供了与内部和外部调查人员的主要联系点
受训人员,是国家阿尔茨海默氏症协调中心(NACC)的主要渠道,两者都用于交付
用于收集数据,并为当地调查人员获取数据集。核心的存在也是为了确保严谨和
数据处理的每一步,从输入和编码,到分析和传播,都具有可重复性。
核心(A)与1佛罗里达ADRC的中心主题相一致,巩固、消除识别和提供
向调查人员提供生物标志物数据,(B)特别强调纵向分析的数据分析方法,
特别是在支持和教育早期职业调查人员使用它们方面,(C)支持生物医学信息学
和电子健康调查人员访问和使用大型数据存储库(例如,佛罗里达数据信托公司的数据存储库)
关于痴呆症的新假说的发展。核心还提供了协作方面的领导力
开发用于数据编码和传输的开源应用程序。核心的目标包括:
(1)对已验证的数据提供高质量的数据管理流程和系统;
集成/合并(跨中心运营),安全、记录良好,并与其他调查人员共享
地方和全国范围内;
(2)在a)研究设计、b)研究措施的选择、c)数据方面提供最新的数据分析咨询
在数据收集和分析之前、期间和之后,对调查结果进行解释,以及(E)陈述。
核心还确保1佛罗里达州ADRC研究的严密性和可重复性,支持(A)预注册
手稿,(B)使用可复制和开放源码进行数据分析,(C)使用印刷前出版物
广泛传播和“公开同行评议”的稿件。
(3)在全国范围内支持更大的ADRC调查人员社区,以及那些隶属于1佛罗里达的调查人员
ADRC,具有开源数据管理工具和应用程序;以及
42个在线培训模块(包括实践数据集和代码),通过研究教育部分,在
方法从简单的描述性到高级的生长和生存模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL MARSISKE其他文献
MICHAEL MARSISKE的其他文献
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{{ truncateString('MICHAEL MARSISKE', 18)}}的其他基金
1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core
1佛罗里达阿尔茨海默病研究中心数据管理和统计 (DMS) 核心
- 批准号:
10663226 - 财政年份:2020
- 资助金额:
$ 42.7万 - 项目类别:
1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core
1佛罗里达阿尔茨海默病研究中心数据管理和统计 (DMS) 核心
- 批准号:
10190774 - 财政年份:2020
- 资助金额:
$ 42.7万 - 项目类别:
1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core
1佛罗里达阿尔茨海默病研究中心数据管理和统计 (DMS) 核心
- 批准号:
9921604 - 财政年份:2020
- 资助金额:
$ 42.7万 - 项目类别:
Physical, Cognitive and Mental Health in Social Context
社会背景下的身体、认知和心理健康
- 批准号:
8240469 - 财政年份:2003
- 资助金额:
$ 42.7万 - 项目类别:
Physical, Cognitive and Mental Health in Social Context
社会背景下的身体、认知和心理健康
- 批准号:
6592021 - 财政年份:2003
- 资助金额:
$ 42.7万 - 项目类别:
Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's Disease
衰老、MCI 和阿尔茨海默病认知非药物干预研究培训
- 批准号:
10634548 - 财政年份:2003
- 资助金额:
$ 42.7万 - 项目类别:
Physical, Cognitive and Mental Health in Social Context
社会背景下的身体、认知和心理健康
- 批准号:
8475035 - 财政年份:2003
- 资助金额:
$ 42.7万 - 项目类别:
Physical, Cognitive and Mental Health in Social Context
社会背景下的身体、认知和心理健康
- 批准号:
8767435 - 财政年份:2003
- 资助金额:
$ 42.7万 - 项目类别:
Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's Disease
衰老、MCI 和阿尔茨海默病认知非药物干预研究培训
- 批准号:
10180805 - 财政年份:2003
- 资助金额:
$ 42.7万 - 项目类别: