New York Obesity Research Center

项目摘要/摘要 纽约肥胖营养研究中心(NYNORC)的主要目标是召集和支持- 由其核心服务、试点和可行性以及浓缩项目资助哥伦比亚大学的调查人员 阿尔伯特·爱因斯坦医学院研究肥胖症。该中心的主题包括：病因学， 肥胖症的病理生理学和并发症；治疗策略；体重调节的生理学和 营养使用；开发研究营养与肥胖的新工具和战略；以及培训和 发展科学家研究营养与肥胖。根据设计，NYNORC的一个特别优势是 明确承诺促进多学科研究，纳入与以下方面有关的基本观察 营养、代谢和行为生物学，将这些见解应用于临床治疗 预防和治疗肥胖。我们基地的规模和广度为 协作和工作效率。在本周期内，研究基础已从109个增加到115个。 会员。目前，NYNORC成员是206个与肥胖有关的赠款的个人投资者，总额为6000万美元/年 直接费用：来自美国国立卫生研究院的166笔赠款，总计4800万美元/年(1300万挪威第纳尔)和40个基金会和 制药实体每年资助1100万美元与肥胖相关的拨款。NYNORC成员是 12个NIH培训补助金，14个P30和P50计划项目，哥伦比亚大学的CTSA，以及10K的导师 系列奖和4个F31毕业生奖。这些努力得到了我们的三个生物医学研究核心的支持： 人类表型、动物表型和分子生物学/分子遗传学。自上次提交以来， 这些核心已经为115个成员提供了~4万项服务，其中包括人类提供的~8464项服务 表型核心，动物表型核心的10,231项服务和&gt；20,000项服务请求 分子遗传学/分子生物学核心。该研究基地还得到了一项非常成功的试验的支持 &可行性计划-由赞助机构补贴-授予120万至13美元 自上次提交以来的调查人员和今年夏天开始的3个新奖项。此外，通过 Naomi Berrie糖尿病中心糖尿病研究前沿项目，Russell Berrie倡议 肥胖的神经生物学和最近启动的初步翻译研究计划 NYNORC每年可以额外获得约200万美元的资金，以支持与 肥胖症的发病机制及治疗。NYNORC是一家充满活力的企业，拥有强大的机构 支持允许它进化和蓬勃发展，因为它促进了肥胖研究中的新的和协作的科学。这 进化在NYNORC成员创造智力和物质资源方面的作用是显而易见的 解决新冠肺炎疫情的基本研究方法和翻译研究方法。

PROJECT SUMMARY/ABSTRACT The New York Obesity Nutrition Research Center (NYNORC) has as its primary aim to convene and support - by its Core Services, Pilot & Feasibility and Enrichment programs - funded investigators at Columbia University and the Albert Einstein College of Medicine studying obesity. The themes for this Center include: the etiology, pathophysiology and complications of obesity; treatment strategies; the physiology of weight regulation and nutrient use; development of new tools and strategies for the study of nutrition and obesity; and the training and development of scientists to study nutrition and obesity. A particular strength of the NYNORC, by design, is an explicit commitment to the promotion of multidisciplinary research that integrates basic observations relating to nutritional, metabolic and behavioral biology, with the application of these insights to clinical approaches to the prevention and treatment of obesity. The size and breadth of our base has provided a strong basis for collaborations and productivity. During the current cycle, the research base has grown from 109 to 115 funded members. Currently, NYNORC members were PIs on 206 obesity-related grants totaling $60M/annum in direct costs: 166 grants from NIH totaling $48M/annum ($13M NIDDK) and 40 foundations and pharmaceutical entities supported obesity-related grants totaling $11M/annum. NYNORC Members are PIs of 12 NIH training grants, 14 P30 and P50 program projects, the CTSA at Columbia, and mentors of 10 K series and 4 F31 graduate awards. These efforts are supported by our three Biomedical Research Cores: Human Phenotyping, Animal Phenotyping and Molecular Biology/Molecular Genetics. Since the last submission, the Cores have provided ~40,000 services to 115 members, including ~8464 services provided by the Human Phenotyping Core, 10,231 services from the Animal Phenotyping Core and >20,000 service requests by the Molecular Genetics/Molecular Biology Core. The research base is also supported by a highly successful Pilot & Feasibility Program – subsidized by the sponsoring institutions - that awarded $1.2M to 13 investigators since the last submission and 3 new awards to begin this summer. In addition, through the Naomi Berrie Diabetes Center programs in Frontiers in Diabetes Research, the Russell Berrie Initiative in the Neurobiology of Obesity and the recently inaugurated Preliminary Translational Research Program, the NYNORC has access to an additional ~$2M in annual funds to support innovative studies related to the pathogenesis and treatment of obesity. The NYNORC is a dynamic enterprise that has strong institutional support permitting it to evolve and thrive as it fosters novel and collaborative science in the study of obesity. This evolution is apparent in the role of members of the NYNORC in creating intellectual and physical resources for addressing basic and translational research approaches to COVID-19 epidemic.