Neuroanatomic and Functional Characterization of Cerebellar Circuits Mediating Ingestive Behaviors

介导摄取行为的小脑回路的神经解剖学和功能特征

• 批准号: 10667656
• 负责人: RUDOLPH L LEIBEL
• 金额: $ 61.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-20 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667656
• 关键词: Anterior; Attention; Behavior; Behavioral; Body Weight; Brain; Brain region; Cells; Cerebellar Cortex; Cerebellum; Cerebral cortex; Cognition; Cognitive; Complex; Consumption; Data; Desire for food; Disease; Eating; Electrophysiology (science); Environment; Fatty acid glycerol esters; Feeding behaviors; Foundations; Goals; Human; Internet; Learning; Link; Maps; Mediating; Metabolic; Methods; Modeling; Monitor; Motor; Movement; Mus; Neural Pathways; Neuroanatomy; Neurons; Obesity; Physiological; Physiology; Play; Prevention; Regulation; Resolution; Role; Silicon; Site; Spinal Cord; Synaptic plasticity; Viral; brain behavior; cell type; experience; experimental study; feeding; genetic manipulation; granule cell; hedonic; microstimulation; motivated behavior; motor control; neural circuit; novel; obesity treatment; optogenetics; pharmacologic

Project Summary/Abstract Understanding the interconnected web of brain circuits that regulate body weight (fat) is vital for the prevention and treatment of obesity. The goal of this proposal is to establish a novel role for the cerebellum in feeding behaviors related to obesity. The vast computational power of the cerebellum (>1/2 of all neurons in the human brain are cerebellar granule cells) has traditionally been considered in relation to movement. However, mounting evidence suggests that cerebellar machinery for learning and predictive control operates across a much wider domain: ranging from autonomic functions to cognitive and motivated behaviors. Guided by our recent finding of a specific region of the mouse cerebellum that potently drives ingestive behavior, the proposed experiments leverage state-of-the-art methods for mapping, monitoring, and manipulating neural circuits in mice to elucidate cerebellar roles in feeding behavior. The proposed studies will lay the groundwork for imputing a vital role of the cerebellum in optimizing feeding behaviors in the context of extant physiological and environmental conditions.

项目摘要/摘要 了解调节体重（FAT）的互连网络对预防至关重要 和肥胖的治疗。该提案的目的是确定小脑在喂养中的新作用 与肥胖有关的行为。小脑的巨大计算能力（人类所有神经元的1/2 传统上，大脑是小脑颗粒细胞）。但是，安装 有证据表明，用于学习和预测控制的小脑机械在更广泛的地方运行 领域：从自主功能到认知和动机行为。在我们最近发现的指导下 小脑小脑的特定区域有效驱动摄入行为，提出了实验 利用最新的方法来映射，监测和操纵小鼠的神经回路以阐明 小脑在进食行为中的作用。拟议的研究将为裁定的基础奠定基础 在现存的生理和环境条件下，小脑优化喂养行为。