Low Latency Eye-Motion Compensation

低延迟眼动补偿

• 批准号: 10186175
• 负责人: Alfredo Dubra
• 金额: $ 45.99万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10186175
• 关键词: Address; Algorithms; Bypass; Clinical; Communities; Computer software; Crystalline Lens; Data; Diagnosis; Disease; Disease Progression; Early Diagnosis; Eye; Eye Movements; Eye diseases; Failure; Financial compensation; Friction; Functional Imaging; Glaucoma; Goals; Human; Image; Individual; Inner Nuclear Layer; Light; Location; Measurement; Measures; Mechanics; Microscopic; Mission; Modeling; Motion; Movement; Ocular Motility Disorders; Ophthalmoscopes; Ophthalmoscopy; Optics; Pathologic Nystagmus; Pathology; Play; Psychophysics; Pupil; Research; Residual state; Resolution; Retina; Rotation; Sampling; Scanning; Speed; Stimulus; Structure; System; Technology; Testing; Time; Visualization; adaptive optics; adaptive optics scanning laser ophthalmoscopy; cellular imaging; cost; human imaging; human subject; image registration; imaging modality; improved; instrument; instrumentation; millisecond; optic nerve disorder; prediction algorithm; retinal imaging; sample fixation; software development

PROJECT SUMMARY Adaptive optics (AO) scanning ophthalmoscopy allows non-invasive visualization of microscopic retinal structures by correcting the optical blur that is unique to each eye. In these instruments, however, image distortion due to involuntary fixational eye movement is a barrier to improving the understanding, early diagnosing, and management of eye disease. We propose to develop high-bandwidth eye motion stabilization technology and image registration software to mitigate this distortion even in subjects with the most extreme forms of involuntary eye motion, including nystagmus. This will be achieved by using a high frame rate pupil tracker that measures the eye’s orientation and by steering galvanometric optical scanners to simultaneously stabilize the view of the pupil and the retina as seen by AO scanning ophthalmoscopes with sub-millisecond total latency. Our goal here is to develop low-cost, low-complexity, and high-bandwidth retinal imaging stabilization instrumentation that can be used to upgrade both AO and non-AO ophthalmoscopes, using control algorithms that incorporate eye motion prediction, electronic and mechanical latency. Finally, we will also develop image registration software for scanning ophthalmoscopes that uses the high frame rate pupil tracking to improve accuracy and reduce failure rate, as well as automate the identification of and un-distort reference frames. The proposed technology will be applicable to all scanning ophthalmoscopes, irrespective of imaging modality.

项目摘要 自适应光学（AO）扫描检眼镜允许显微视网膜的非侵入性可视化 通过校正每只眼睛所特有的光学模糊，然而，在这些工具中，图像 由于不自主的注视性眼球运动引起的变形是提高理解的障碍， 眼科疾病的诊断和管理。我们建议开发高带宽的眼动稳定 技术和图像配准软件，以减轻这种失真，即使在最极端的主题 包括眼球震颤在内的无意识眼球运动。这将通过使用高帧率瞳孔来实现 跟踪器，测量眼睛的方向，并通过操纵检流计光学扫描仪， 稳定瞳孔和视网膜的视图，如通过AO扫描检眼镜所看到的， 延迟。我们的目标是开发低成本、低复杂度和高带宽的视网膜成像稳定技术 可用于升级AO和非AO检眼镜的仪器，使用控制算法 其结合了眼睛运动预测、电子和机械延迟。最后，我们还将发展形象 用于扫描检眼镜的配准软件，其使用高帧速率瞳孔跟踪来改善 准确性和降低故障率，以及自动识别和校正参考帧。的 所提出的技术将适用于所有扫描检眼镜，而与成像模态无关。