Axially-resolved Spectroscopic Ophthalmic Imaging

轴向分辨光谱眼科成像

• 批准号: 8860986
• 负责人: Alfredo Dubra
• 金额: $ 35.98万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8860986
• 关键词: Accounting; Affect; Age related macular degeneration; American; Biological Markers; Blindness; Cell Death; Cells; Cellular Structures; Chemicals; Clinical; Color; Complex; Data; Detection; Diagnosis; Diagnostic; Disease; Early Diagnosis; Epiretinal Membrane; Eye; Eye diseases; Feedback; Financial compensation; Fluorescein Angiography; Fundus photography; General Practitioners; Generations; Goals; Grant; Health; Human; Image; Imagery; Individual; Judgment; Knowledge; Light; Location; Macular Hole; Measurement; Membrane; Methods; Microscopic; Monitor; Noise; Ophthalmologist; Ophthalmoscopes; Ophthalmoscopy; Optics; Optometrist; Outcome; Pathology; Performance; Population; Publishing; Research; Resolution; Retina; Retinal; Retinal Diseases; Scanning; Sensitivity and Specificity; Serous; Signal Transduction; Site; Spectrum Analysis; Structure; Technology; Testing; Thick; Traction; Translating; Variant; Vision; adaptive optics; base; c new; cell type; design; improved; lens; new technology; novel; prevent; public health relevance; spectroscopic imaging; tool

 DESCRIPTION (provided by applicant): Early detection of eye disease is critical for preventing vision loss that affects more than 38 million Americans. Current diagnostic tools often reveal retinal changes only after vision loss has already occurred. Tests of visual function are limited by their subjectivity, and by the pooling of signals from tens to thousands of retinal cells. Tests of retinal structure are limited by the substantial anatomical variation among individuals, which makes early disease detection impossible without baseline measurements. In most cases structural tests can therefore detect only macroscopic changes that follow major cell death. These limitations could be overcome by a non-invasive method to detect chemical changes that precede cell death. For this purpose, we will develop two novel technologies, adaptive longitudinal chromatic aberration (LCA) correction and axially- resolved hyperspectral retinal imaging. These will be demonstrated in combination with ophthalmic adaptive optics, to characterize the spectra of idiopathic epiretinal membranes, with or without associated retinal traction or macular hole, as well as age-related macular degeneration and central serous retinopathy.

 描述（由申请人提供）：早期发现眼疾对于预防影响超过3800万美国人的视力丧失至关重要。目前的诊断工具通常只在视力丧失发生后才能显示视网膜变化。视觉功能的测试受到主观性的限制，并且受到来自数十到数千个视网膜细胞的信号的汇集的限制。视网膜结构的测试受到个体之间大量解剖学差异的限制，这使得没有基线测量就不可能进行早期疾病检测。因此，在大多数情况下，结构测试只能检测主要细胞死亡后的宏观变化。这些限制可以通过一种非侵入性的方法来克服，以检测细胞死亡前的化学变化。为此，我们将开发两种新的技术，自适应纵向色差（LCA）校正和轴向分辨高光谱视网膜成像。这些将结合眼科自适应光学来证明，以表征特发性视网膜前膜的光谱，有或没有相关的视网膜牵引或黄斑裂孔，以及年龄相关性黄斑变性和中心性浆液性视网膜病变。