Increasing the isoplanatic patch in adaptive optics ophthalmoscopy

项目摘要 眼睛的光学系统受到使视网膜图像模糊的缺陷（波前像差）的影响。这种模糊限制了 我们在不可逆转的损害和视力丧失发生之前诊断眼疾的能力。自适应光学 检眼镜检查可以校正这种模糊，这种模糊对于每只眼睛和视网膜位置是唯一的。当前AO 检眼镜只能捕获非常小的视网膜区域的图像，因为它们不能校正 整个视网膜的波前像差的变化。这种限制阻碍了这项技术的使用， 发现疾病的早期迹象，这反过来又使早期治疗成为可能，从而减轻不可逆的视力 损失在这里，我们建议首先测量波前像差如何在人类受试者的视网膜上变化 改善未来所有AO检眼镜的设计和操作。我们还提出了两个新的 用于测量和校正在整个视网膜上变化的波前像差以增加视场的方法 看这些工具。首先，我们建议在视场中的各个点处顺序地测量像差。 查看并随后在每个视网膜位置处提供适当的顺序波前校正。这种低成本、低 复杂性方法可用于使当前AO扫描检眼镜的视网膜覆盖范围加倍。 第二种方法使用两个波前校正器，其最佳轴向位置将由下式确定： 使用人群中波前像差随视网膜位置和波长变化的数据。这 更复杂的方法旨在至少四倍的视网膜覆盖。由此产生的视野的增加 将是将AO检眼镜转换为实用临床工具的重要一步， 眼科疾病的诊断和治疗。

PROJECT SUMMARY The optics of the eye suffer from imperfections (wavefront aberrations) that blur retinal images. This blur limits our ability to diagnose eye disease before irreversible damage and vision loss take place. Adaptive optics (AO) ophthalmoscopy can correct for this blur, which is unique to each eye and retinal location. Current AO ophthalmoscopes can only capture images of very small retinal areas because they cannot correct for the variation of the wavefront aberrations across the retina. This limitation impedes the use of this technology for detecting early signs of disease, which in turn, enable the early treatment that would mitigate irreversible vision loss. Here we propose to first measure how wavefront aberrations change across the retina in a human subject population to improve the design and operation of all future AO ophthalmoscopes. We also propose two novel methods for measuring and correcting wavefront aberrations that vary across the retina to increase the field of view of these instruments. First, we propose to measure aberrations sequentially at various points in the field of view and then deliver appropriate sequential wavefront corrections at each retinal location. This low-cost, low complexity approach could be used to double the retinal coverage of current AO scanning ophthalmoscopes. The second approach uses two wavefront correctors, the optimal axial positions of which will be determined by using the data on wavefront aberration changes with retinal location and wavelength across the population. This more complex approach aims to at least quadruple retinal coverage. The resulting increase in the field of view will be a major step towards translating AO ophthalmoscopy into a practical clinical tool for improving the diagnosis and treatment of eye diseases.