Increasing the isoplanatic patch in adaptive optics ophthalmoscopy

项目总结 眼睛的光学系统会受到视网膜图像模糊的缺陷(波前像差)的影响。这种模糊的界限 我们在不可逆转的损害和视力丧失发生之前诊断眼病的能力。自适应光学(AO) 眼底镜可以纠正这种模糊，这是每个眼睛和视网膜位置独一无二的。当前的AO 眼底镜只能捕捉到非常小的视网膜区域的图像，因为它们不能纠正 整个视网膜的波前像差的变化。这一限制阻碍了这项技术在 检测疾病的早期迹象，进而使早期治疗成为可能，从而减轻不可逆转的视力 损失。在这里，我们建议首先测量波前像差如何在人类受试者的视网膜上发生变化 人口，以改进所有未来的声光检眼镜的设计和操作。我们还提出了两部小说 测量和矫正在整个视网膜上变化的波前像差以增加视野的方法 查看这些工具。首先，我们建议在不同的点上顺序地测量像差 查看并在每个视网膜位置提供适当的连续波前校正。这种低成本、低成本的 复杂性方法可用于将目前的AO扫描眼底镜的视网膜覆盖率提高一倍。 第二种方法使用两个波前校正器，其最佳轴向位置将由 使用波前像差的数据会随着人群中视网膜位置和波长的变化而变化。这 更复杂的方法旨在至少将视网膜覆盖率提高四倍。随之而来的视野扩大 将是将AO眼底镜转化为实用的临床工具的重要一步，以改善 眼科疾病的诊断和治疗。

PROJECT SUMMARY The optics of the eye suffer from imperfections (wavefront aberrations) that blur retinal images. This blur limits our ability to diagnose eye disease before irreversible damage and vision loss take place. Adaptive optics (AO) ophthalmoscopy can correct for this blur, which is unique to each eye and retinal location. Current AO ophthalmoscopes can only capture images of very small retinal areas because they cannot correct for the variation of the wavefront aberrations across the retina. This limitation impedes the use of this technology for detecting early signs of disease, which in turn, enable the early treatment that would mitigate irreversible vision loss. Here we propose to first measure how wavefront aberrations change across the retina in a human subject population to improve the design and operation of all future AO ophthalmoscopes. We also propose two novel methods for measuring and correcting wavefront aberrations that vary across the retina to increase the field of view of these instruments. First, we propose to measure aberrations sequentially at various points in the field of view and then deliver appropriate sequential wavefront corrections at each retinal location. This low-cost, low complexity approach could be used to double the retinal coverage of current AO scanning ophthalmoscopes. The second approach uses two wavefront correctors, the optimal axial positions of which will be determined by using the data on wavefront aberration changes with retinal location and wavelength across the population. This more complex approach aims to at least quadruple retinal coverage. The resulting increase in the field of view will be a major step towards translating AO ophthalmoscopy into a practical clinical tool for improving the diagnosis and treatment of eye diseases.