Core B: System Biological Analyses of Innate and Adpative Responses to Vaccination
Core B: System Biological Analyses of Innate and Adpative Responses to Vaccination
批准号:
10201499
负责人:
Mark Joseph Mulligan
金额:
$512.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-07-13 至 2022-06-30
关键词:
2019-nCoVATAC-seqAddressAspirate substanceAwardBloodCOVID-19Cell Culture TechniquesCellsCloningCompetenceDiagnosticDiseaseDonor personEpigenetic ProcessEpithelial CellsEpitopesGenetic TranscriptionGrantHeterogeneityHospitalsHumanImmuneImmune responseImmune systemImmunityImmunologyInfectionInnate Immune ResponseKnowledgeLearningLungLung TransplantationMetabolicMolecularMolecular ProfilingMyelogenousMyeloid CellsNatural ImmunityParentsPathogenesisPathogenicityPeripheral Blood Mononuclear CellSamplingScienceSiteStimulusStructure of parenchyma of lungSystemSystems BiologyTherapeuticVaccinationVaccine DesignVaccinesVirusWorkairway epitheliumbiological systemscoronavirus diseasedesignepigenomicsglobal healthimprintindexinginsightmacrophagemetabolomicsmonocytemultiple omicsnovelpandemic diseasepreventprogramsresponsesingle-cell RNA sequencingtranscriptometranscriptomicstransplant centers
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) pandemic
poses a major global health challenge. Coronavirus disease (COVID-19) is caused by SARS-
CoV-2 and represents the causative agent of a potentially fatal disease. Science has moved very
rapidly in isolating, sequencing, and cloning the virus, and developing diagnostic kits, within a
matter of weeks. However, major knowledge gaps remain about the dynamic interaction between
the human immune system and the SARS-CoV-2. In particular, several fundamental questions
regarding its pathogenesis, and the mechanisms of protective immunity that need to be induced
by vaccination, remain unanswered. Learning how the immune system senses SARS-CoV-2
infection and orchestrates protective immunity is critical for designing effective vaccines and
therapeutics. Our previous work using systems biology, multi-omics approaches to analyze
immune responses to vaccination in humans has delineated molecular signatures of innate
immunity to vaccination and infection and have provided rich mechanistic insights into the immune
response. In this proposal, we propose a site-specific study to analyze samples from the
IMPACC sub-study performed at Emory. We will use an integrated multi-omics approach (single
cell transcriptomics, metabolomics, single cell epigenomics) to study innate immunity to COVID-
19 infection in humans. We will obtain PBMCs and tracheal aspirate samples from the IMPACC
sub-study that will be conducted at Emory. We will address the following questions: What are the
molecular and cellular signatures of the immune response to COVID-19 infection in the blood and
tracheal aspirates of infected subjects? Does COVID-19 infection exert an epigenetic imprint of
innate immunity? What is the molecular landscape and function of myeloid cell subsets and airway
epithelial cells in the healthy lung, and following COVID-19 infection? These questions will be
addressed in the following specific aims: 1) Determine the single cell transcriptional and
epigenetic landscape of the immune response to COVID-19 infection in blood and tracheal
aspirates, and 2) Determine the molecular identity and functions of myeloid cell subsets and
epithelial cells in human lung and their response to COVID-19 infection. These studies will provide
significant insight into the human immune response to COVID-19 infection that can be leveraged
for designing vaccines and therapeutics to prevent or treat the infection.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU) - DMID 21-0012
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批准号:10411291
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项目类别:
-
资助金额:$134.15万
-
财政年份:2021
-
负责人:Mark Joseph Mulligan
-
依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU) – DMID 21-0004
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批准号:10416210
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项目类别:
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资助金额:$62.54万
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财政年份:2021
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负责人:Mark Joseph Mulligan
-
依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
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批准号:10493613
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项目类别:
-
资助金额:$37.58万
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财政年份:2021
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负责人:Mark Joseph Mulligan
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依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
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批准号:10493604
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项目类别:
-
资助金额:$54.37万
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财政年份:2021
-
负责人:Mark Joseph Mulligan
-
依托单位:
Core B: System Biological Analyses of Innate and Adpative Responses to Vaccination
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批准号:10345983
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项目类别:
-
资助金额:$46.64万
-
财政年份:2021
-
负责人:Mark Joseph Mulligan
-
依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
-
批准号:10265637
-
项目类别:
-
资助金额:$682.04万
-
财政年份:2021
-
负责人:Mark Joseph Mulligan
-
依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
-
批准号:10228783
-
项目类别:
-
资助金额:$921.48万
-
财政年份:2020
-
负责人:Mark Joseph Mulligan
-
依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
-
批准号:10534123
-
项目类别:
-
资助金额:$63.19万
-
财政年份:2020
-
负责人:Mark Joseph Mulligan
-
依托单位:
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
-
批准号:10306410
-
项目类别:
-
资助金额:$63.87万
-
财政年份:2020
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Units: Overall Administration, Clinical Operations Support, Protocol Development, Implementation and Assays.
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批准号:10083147
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项目类别:
-
资助金额:$19.07万
-
财政年份:2019
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Units: Overall Administration, Clinical Operations Support, Protocol Development
-
批准号:10673575
-
项目类别:
-
资助金额:$10.65万
-
财政年份:2019
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Units: Overall Administration, Clinical Operations Support, Protocol Development
-
批准号:10454731
-
项目类别:
-
资助金额:$10.63万
-
财政年份:2019
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Units: Protocol Development and Implementation for a Natural History Challenge Study for Influenza
-
批准号:9934606
-
项目类别:
-
资助金额:$4.0万
-
财政年份:2019
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Unit: Phase I Clinical Trial to Evaluate a Hepatitis E Vaccine
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批准号:9915385
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项目类别:
-
资助金额:$59.96万
-
财政年份:2018
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Unit: Phase I Clinical Trial to Evaluate a Hepatitis E Vaccine
-
批准号:10453426
-
项目类别:
-
资助金额:$0.27万
-
财政年份:2018
-
负责人:Mark Joseph Mulligan
-
依托单位:
VTEU PHASE 2 EBOLA VIRUS VACCINE TRIAL
-
批准号:10001401
-
项目类别:
-
资助金额:$119.71万
-
财政年份:2018
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Units: Protocol Development and Implementation for a Phase I Trial for Influenza Vaccine
-
批准号:9934625
-
项目类别:
-
资助金额:$58.89万
-
财政年份:2018
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Unit - Clinical Operations Support
-
批准号:9737180
-
项目类别:
-
资助金额:$50.78万
-
财政年份:2018
-
负责人:Mark Joseph Mulligan
-
依托单位:
Vaccine and Treatment Evaluation Units: Protocol Development for a Phase III Dengue Vaccine Study
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批准号:9915789
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项目类别:
-
资助金额:$1.62万
-
财政年份:2017
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负责人:Mark Joseph Mulligan
-
依托单位:
VACCINE TREATMENT AND EVALUATION UNIT: CLINICAL OPERATIONS SUPPORT
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批准号:9571163
-
项目类别:
-
资助金额:$36.97万
-
财政年份:2017
-
负责人:Mark Joseph Mulligan
-
依托单位:
国内基金
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