Pilot Study to Determine Health Effects of e-cigarette in Healthy Young Adults

弗吉尼亚州综合转化性健康研究所(ITHRIV)计划是 弗吉尼亚州联邦的公共和私人机构带来了团队科学、创新、 并承诺培训下一代临床和翻译研究人员。我们的三个iTHRIV 合作伙伴包括弗吉尼亚大学(弗吉尼亚州中部)、弗吉尼亚理工大学Carilion(弗吉尼亚州西南部)和Inova 医疗系统(弗吉尼亚州北部)。我们的两个iTHRIV附属机构是开放科学中心和 夏洛茨维尔的许可和风险集团。ITHRIV的一个独特优势在于集成数据 科学方法贯穿临床转化研究的方方面面，以加速发现和 改善我们社区的健康。ITHRIV有一个中央租户作为组织者 原则：医疗保健解决方案隐藏在未得到充分利用的数据中。我们的总体目标是深化iTHRIV 支持临床转化性研究的基础设施，以造福不同的农村和城市人口 ITHRIV成员临床医生所提供的服务。跨此CTSA组件的统一方法 应用是集成数据和数据分析，以加速和简化科学工作流 用于临床试验、创新的治疗进展和创建更个性化的 医疗保健的方法。数据科学是我们团队的一项特殊优势，将使我们能够 通过创建公共资源来改变我们的跨州信息基础设施，这是一项可扩展的研究 由iTHRIV合作伙伴共享的托管平台，将作为我们信息学支持的基础。它 将为研究礼宾服务、人力和电子方法提供基础设施 以支持临床转化研究。该平台将结合以数据为中心的方法来 通过以人为中心托管和共享数据集、应用程序和其他研究对象进行发现 设计和系统架构的方法。公地被设计为既是一种 建立启用数据所需的流程和工具的技术框架和方法 在合作伙伴位置之间共享。礼宾服务通知研究人员并将其与培训联系起来， 支持服务和合规资源，以简化临床转化研究流程。这个 通过下议院和礼宾服务，iTHRIV的使命是消除发现的障碍 在弗吉尼亚州和更远的地方。ITHRIV共享空间在概念上类似于NIH数据共享空间，并且 跨合作伙伴站点实施这一框架将消除数据访问和其他方面的障碍 研究对象(算法、最佳实践等)，同时执行数据安全使用方面的合规性。 ITHRIV将把我们公地世界级数据科学团队的专业知识与我们的 杰出的临床翻译研究人员，以发现医疗保健解决方案。

The integrated Translational Health Research Institute of Virginia (iTHRIV) program is a collaboration of public and private institutions across the Commonwealth of Virginia that brings team science, innovation, and a commitment to train the next generation of clinical and translational researchers. Our three iTHRIV partners include University of Virginia (Central VA), Virginia Tech Carilion (Southwestern VA) and Inova Health Systems (Northern VA). Our two iTHRIV affiliates are the Center for Open Science and the Licensing and Ventures Group in Charlottesville. A particular strength of iTHRIV lies in integrating data science approaches through all aspects of clinical translational research in order to speed discovery and improve the health of our communities. iTHRIV has a central tenant that serves as the organizing principle: health care solutions are hidden in underutilized data. Our overall goal is to deepen the iTHRIV infrastructure to support clinical translational research to benefit the diverse rural and urban populations that iTHRIV member clinicians serve. The unified approach across the components of this CTSA application is to integrate data and data analytics to accelerate and streamline scientific workflows for clinical trials, innovative therapeutic advancements, and the creation of more personalized approaches to healthcare. Data science is a particular strength of our team and will allow us to transform our cross-state informatics infrastructure by creating The Commons, a scalable research hosting platform shared by iTHRIV partners that will serve as the foundation for our informatics support. It will provide the infrastructure for the Research Concierge Services, the human and electronic approach to supporting clinical translational research. This platform will combine data-centered approaches to discovery by hosting and sharing datasets, applications, and other research objects with a humancentered approach to design and systems architecture. The Commons is designed to serve both as a technical framework and an approach to establishing processes and tools necessary to enable data sharing between partner locations. The Concierge service informs and connects researchers to training, support services and compliance resources to streamline the clinical translational research process. The mission of iTHRIV, through the Commons and the Concierge Services, is to remove barriers to discovery in Virginia and beyond. The iTHRIV Commons is conceptually similar to the NIH Data Commons, and the implementation of this framework across partner sites will remove barriers to data access and other research objects (algorithms, best practices, etc.), while enforcing compliance in the secure use of data. iTHRIV will marry the expertise of our world class data science teams in The Commons to our outstanding clinical translational researchers in order to uncover health care solutions.