MASALA-2G: Multi-level Assessment of the South Asian Life-course of Atherosclerosis (2nd Generation Offspring Study)

项目摘要/摘要 这个职业发展奖将为Nilay Shah博士提供作为一个独立的 南亚裔美国人社区和临床心血管疾病预防研究人员 他在人口流行病学和临床心血管医学方面的经验。南 亚洲人动脉粥样硬化性心血管疾病(ASCVD)的负担在 与其他种族/民族相比年龄较小，但对先前的心血管健康知之甚少 在第二代年轻成年南亚裔美国人中告知这种风险的早期生活预防策略- 增强组。拟议的申请旨在试行MASALA-2G，即南方的多层次评估 亚洲人动脉粥样硬化的生活过程(第二代子代研究)，对动脉粥样硬化介质的子代研究 主要为第一代的居住在美洲(Masala)的南亚人的动脉粥样硬化 南亚移民。Masala-2G代表了一项关于心血管健康的基础研究 南亚裔美国人，并与国家心肺血液研究所直接结盟 使命和目的促进不同人群心脏病的预防。在.之下 Namratha Kandula博士和Mark Huffman博士的指导，他们是联合 在南亚健康、预防干预试验、社区参与研究和 实施科学，沙阿博士提出了一个全面的研究和多学科的职业生涯 由正式课程、强化指导和队列体验式培训组成的发展计划 健康差距人口的管理和社区参与，先进的统计方法 多层次关联、基因组学和实施科学。具体目标是：(1)试点 对21-40岁的第二代SA成年人心血管健康的Masala-2G研究，他们是 Masala父母研究参与者；(2)确定对心血管健康和冠状动脉疾病有多层次贡献的因素 Masala-2G参与者的动脉钙；以及(3)心血管健康促进行为的背景 根据干预地图框架，根据量化结果对这一人群进行干预。 拟议的研究和培训将在西北大学进行，该大学为沙阿博士提供：(1) 在南亚社区获得无与伦比的基础设施和研究伙伴关系，(2)a 具有全面相关专业知识的多学科导师和协作者团队，(3)强大 心脏病科和预防医学部的机构支持，以及(4)培训 机会包括西北大学社区卫生中心、全球心血管中心 健康、临床和翻译科学研究所。最终，这项研究和职业发展将 使Shah博士能够过渡到南亚人群中心血管预防的独立研究。

PROJECT SUMMARY/ABSTRACT This career development award will provide Dr. Nilay Shah the opportunity to develop as an independent investigator of community and clinical cardiovascular disease prevention in the South Asian American population, and build on his experience in population epidemiology and clinical cardiovascular medicine. South Asians experience a disproportionately higher burden of atherosclerotic cardiovascular disease (ASCVD) at younger ages compared to other race/ethnic groups, but little is known about antecedent cardiovascular health in 2nd generation young adult South Asian Americans to inform early life prevention strategies in this risk- enhanced group. The proposed application aims to pilot MASALA-2G, the Multi-level Assessment of the South Asian Life-course of Atherosclerosis (2nd Generation Offspring Study), an offspring study to the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort who are predominantly 1st generation immigrant South Asians. MASALA-2G represents a foundational investigation in the cardiovascular health of the South Asian American population and aligns directly with the National Heart, Lung, and Blood Institute mission and objective to promote the prevention of heart diseases in diverse populations. Under the mentorship of Drs. Namratha Kandula and Mark Huffman, who are leading researchers with combined expertise in South Asian health, prevention intervention trials, community engaged research, and implementation science, Dr. Shah proposes a comprehensive research and multidisciplinary career development plan composed of formal coursework, intensive mentorship, and experiential training in cohort management and community engagement in health disparity populations, advanced statistical methods for multi-level associations, genomics, and implementation science. The Specific Aims are to: (1) pilot the MASALA-2G study of cardiovascular health in 2nd generation SA adults age 21-40 years, who are offspring of MASALA parent study participants; (2) determine multi-level contributors to cardiovascular health and coronary artery calcium in MASALA-2G participants; and (3) contextualize a cardiovascular health promotion behavioral intervention for this population based on quantitative findings, following the Intervention Mapping framework. The proposed research and training will occur at Northwestern University, which provides Dr. Shah with: (1) access to unparalleled infrastructure and partnerships for research in the South Asian community, (2) a multidisciplinary team of mentors and collaborators with comprehensive relevant expertise, (3) strong institutional support from the Division of Cardiology and Department of Preventive Medicine, and (4) training opportunities including in Northwestern’s Center for Community Health, Center for Global Cardiovascular Health, and Clinical and Translational Sciences Institute. Ultimately, this research and career development will enable Dr. Shah’s transition to independent research for cardiovascular prevention in South Asian populations.