Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's Biomarkers

拉丁裔阿尔茨海默病的危险因素：心血管疾病风险、文化适应、小血管疾病和阿尔茨海默病生物标志物之间的关系

• 批准号: 10351716
• 负责人: Ariana Stickel
• 金额: $ 15.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2022-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10351716
• 关键词: Accounting; Acculturation; Address; Adoption; Age; Aging; Alzheimer' s Disease; Alzheimer' s Disease Pathway; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; American; Amyloid; Amyloid beta-Protein; Ancillary Study; Attenuated; Biological; Biological Markers; Brain; Brain Injuries; Cerebrovascular system; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Data; Dementia; Development; Diabetes Mellitus; Elderly; Enrollment; Estrogens; Face; Gender; Glial Fibrillary Acidic Protein; Goals; Healthcare; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Impaired cognition; Incidence; Income; Individual; Intervention; Investigation; Latina; Latina Population; Latino; Latino Population; Latinx; Lead; Life Expectancy; Light; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Memory; Mexican Americans; Microvascular Dysfunction; National Institute on Aging; Neurocognitive; Outcome; Performance; Physical activity; Plasma; Population; Prevalence; Public Health; Race; Research; Resources; Risk; Risk Factors; Role; Sampling; Scientist; Study of Latinos; Testing; Training; United States; Woman; base; biopsychosocial; black men; black women; cardiovascular disorder risk; cardiovascular health; cerebrovascular pathology; clinical care; cognitive change; dementia risk; epidemiologic data; ethnic difference; ethnic minority; good diet; health disparity; male; men; middle age; mild cognitive impairment; neurofilament; novel; programs; psychosocial; racial and ethnic; sex; social culture; stem; tau Proteins; tool; white matter

PROJECT SUMMARY Latinos/as are a large and growing segment of the United States older adult population and are at increased risk for Alzheimer’s disease and related dementias (ADRDs) compared to non-Latino/a Whites. Evidence suggests that Latinos/as are particularly susceptible to ADRD in the presence of cardiovascular disease risk factors (CVDRFs). Several other factors (e.g., sex, acculturation, Alzheimer’s biomarkers) may influence the degree to which CVDRFs are linked to ADRD risk. For example, our own preliminary data suggest that Latina women with elevated CVDRFs are more likely to have mild cognitive impairment (MCI), an intermediate stage between healthy cognition and ADRD, than men. Interestingly, less acculturation (i.e., maintaining Latino/a culture and less adoption of Anglo-American culture) has been associated with better cardiovascular health, particularly among women, but pilot data has linked lower acculturation to poorer cognition. Finally, Alzheimer’s biomarkers are becoming more accessible but have not been thoroughly investigated among Latinos/as who are more likely to have mixed Alzheimer’s and cerebrovascular pathology (brain damage linked to poor cardiovascular health) as opposed to pure Alzheimer’s pathology. The overarching goal of the proposed study is to develop a comprehensive characterization of cognitive impairment and ADRD risk among middle-age and older Latinos/as. To achieve this, the proposed project will incorporate psychosocial (i.e., acculturation) and biological [i.e., CVDRFs, small vessel disease (a marker of cerebrovasculature), and Alzheimer’s biomarkers] factors to study longitudinal cognitive change among Latinos/as 50+ years old. More specifically, the proposed project will examine detailed cognitive data from the Study of Latinos- Investigation of Neurocognitive Aging (SOL-INCA), SOL-INCA MRI (magnetic resonance imaging), and SOL-INCA AD (Alzheimer’s disease), ancillary studies to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). In aim 1 we seek to characterize gender-specific associations between acculturation and MCI, and test if CVDRFs underly the link between acculturation and MCI status in over 6,000 Latinos/as. In aim 2 we will use gender-specific analysis to determine if small vessel disease accounts for the relationship between CVDRFs and MCI/dementia status (while accounting for acculturation); projected n = 2,400. In aim 3, we will examine whether acculturation or Alzheimer’s biomarkers influence the relationships between small vessel disease and MCI/dementia status; projected n = 2,400. The proposed K08 project will provide the candidate the tools necessary to continue investigating Latino/a cognitive aging and ADRD risk through the National Institute on Aging’s Health Disparities Framework as an independent clinical scientist.

项目总结