Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions

摘要：行政核心 症状科学、代谢组学和多发性慢性病研究中心的总体目标 条件(MCC)“是为了加强护士科学家进行创新翻译的能力 利用尖端代谢组学和微生物组学技术减轻个体症状的研究 与MCC合作。该中心的研究目标是应用下一代代谢组学技术和数据 分析策略，以刺激发现代谢物和代谢途径存在于 MCC患者，专注于跨条件和关联的代谢物和途径协同作用 有严重的疲劳、抑郁或焦虑症状及其群集性，但在有 微囊癌，症状轻微或无症状。与高症状相关的代谢物和代谢途径 严重程度将根据协变量进行评估，如作为生物变量的性别、年龄、慢性压力和 歧视、饮食和药物。一项探索性的目标将另外研究肠道的成分 微生物组是这些症状的潜在协变量。我们的探索性目标利用了我们学校的 微生物组研究的力量和将微生物组与这些症状联系起来的证据。行政部门 CORE将作为中心的关键领导，为中心的工作提供协调支持 会员。行政核心的目标是： 目标1.建立和管理中心的基础设施、战略方向和计划，包括 为能力建设确定新的机会和合作。 目标2.为三个核心和中心的试点项目提供行政和财务监督 使试点项目调查人员能够制定研究计划。 目标3.促进传播中心的资源和活动以及与 该中心的科学主题。 目标4.执行形成性和总结性评价计划，以评估产出、结果和影响 并努力促进中心的可持续发展。 管理核心是基于NINR中心主任逻辑模型构建的 可持续性和战略管理的关键概念和过程，并利用 护理学院内和整个埃默里大学都有特别的资源。行政部门 CORE汇集了该中心科学研究相关领域的国内和国际知名专家 重点提供必要的基础设施，以监督中心的活动，并促进和加强 初级护士调查员的协作、跨学科研究和发展。

Abstract: Administrative Core The over-arching goal of the “Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions (MCC)” is to strengthen the capacities of nurse scientists to conduct innovative translational research using cutting-edge metabolomics and microbiomic technologies to reduce symptoms in individuals with MCC. The research aims of the Center are to apply next-generation metabolomics technology and data analytic strategies to stimulate discovery of the metabolites and metabolic pathways that are present in individuals with MCC, focusing on metabolites and pathways that synergize across conditions and associate with severe symptoms of fatigue, depression, or anxiety and their cluster, but are absent in individuals with MCC with minimal or no symptoms. Metabolites and metabolic pathways associated with high symptom severity will be evaluated in light of covariates such as sex as a biological variable, age, chronic stress and discrimination, diet and medications. An exploratory aim will additionally investigate the composition of the gut microbiome as a potential covariate to these symptoms. Our exploratory aim takes advantage of our School’s strength in microbiome research and evidence linking the microbiome to these symptoms. The Administrative Core will serve as a critical leadership for the Center and provide coordinated support for the work of its members. The aims of the Administrative Core are to: Aim 1. Establish and manage the infrastructure, strategic direction and plan of the Center, including identifying new opportunities and collaborations for capacity building. Aim 2. Provide administrative and financial oversights to three Cores and Center’s pilot projects and enable pilot project investigators to develop a program of research. Aim 3. Promote the dissemination of Center resources and activities and research findings related to the science theme of the Center. Aim 4. Implement formative and summative evaluation plans to assess the outputs, outcomes and impact of the Center and execute efforts to promote sustainability of the Center. The Administrative Core is structured based on the NINR Center Directors Logic Model for Center sustainability and key concepts and processes of strategic management and takes advantage of the exceptional resources available within the School of Nursing and across Emory University. The Administrative Core brings together nationally and internationally known experts in the relevant areas of the Center’s scientific focus to provide the necessary infrastructure to oversee Center activities and facilitate and strengthen collaborative, interdisciplinary research and development of junior nurse investigators.