Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions

症状科学、代谢组学和多种慢性病研究中心

• 批准号: 10456830
• 负责人: Elizabeth Jeanne Corwin
• 金额: $ 20.73万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-14 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456830
• 关键词: Advisory Committees; Age; Anxiety; Area; Biological; Black Populations; Child Health; Chronic stress; Clinical Sciences; Collaborations; Communities; Community Health; Complex; Data Analytics; Data Science; Development; Diet; Discrimination; Ensure; Environment; Evaluation; Fatigue; Funding; Genomics; Goals; Health; Individual; Infrastructure; Institutes; Interdisciplinary Study; International; Investigation; Leadership; Light; Link; Logic; Mental Depression; Mentorship; Metabolic Pathway; Methods; Modeling; Nurses; Outcome; Output; Pathway interactions; Pharmaceutical Preparations; Pilot Projects; Postdoctoral Fellow; Process; Productivity; Research; Research Personnel; Resources; School Nursing; Schools; Science; Scientist; Severities; Strategic Planning; Structure; Symptoms; Techniques; Technology; Translating; Translational Research; United States National Institutes of Health; Universities; Work; base; effectiveness outcome; experience; gut microbiome; innovation; member; metabolomics; microbiome; microbiome analysis; microbiome research; multiple chronic conditions; next generation; pre-doctoral; programs; reduce symptoms; research and development; sex; symptom science

Abstract: Administrative Core The over-arching goal of the “Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions (MCC)” is to strengthen the capacities of nurse scientists to conduct innovative translational research using cutting-edge metabolomics and microbiomic technologies to reduce symptoms in individuals with MCC. The research aims of the Center are to apply next-generation metabolomics technology and data analytic strategies to stimulate discovery of the metabolites and metabolic pathways that are present in individuals with MCC, focusing on metabolites and pathways that synergize across conditions and associate with severe symptoms of fatigue, depression, or anxiety and their cluster, but are absent in individuals with MCC with minimal or no symptoms. Metabolites and metabolic pathways associated with high symptom severity will be evaluated in light of covariates such as sex as a biological variable, age, chronic stress and discrimination, diet and medications. An exploratory aim will additionally investigate the composition of the gut microbiome as a potential covariate to these symptoms. Our exploratory aim takes advantage of our School’s strength in microbiome research and evidence linking the microbiome to these symptoms. The Administrative Core will serve as a critical leadership for the Center and provide coordinated support for the work of its members. The aims of the Administrative Core are to: Aim 1. Establish and manage the infrastructure, strategic direction and plan of the Center, including identifying new opportunities and collaborations for capacity building. Aim 2. Provide administrative and financial oversights to three Cores and Center’s pilot projects and enable pilot project investigators to develop a program of research. Aim 3. Promote the dissemination of Center resources and activities and research findings related to the science theme of the Center. Aim 4. Implement formative and summative evaluation plans to assess the outputs, outcomes and impact of the Center and execute efforts to promote sustainability of the Center. The Administrative Core is structured based on the NINR Center Directors Logic Model for Center sustainability and key concepts and processes of strategic management and takes advantage of the exceptional resources available within the School of Nursing and across Emory University. The Administrative Core brings together nationally and internationally known experts in the relevant areas of the Center’s scientific focus to provide the necessary infrastructure to oversee Center activities and facilitate and strengthen collaborative, interdisciplinary research and development of junior nurse investigators.

摘要：管理核心 “症状科学，代谢组学和多种慢性研究中心 条件（MCC）”是为了增强护士科学家的能力来进行创新的翻译 使用尖端的代谢组学和微生物技术来减轻个体症状的研究 与MCC。该中心的研究目的是应用下一代代谢组学技术和数据 刺激存在的代谢产物和代谢途径的分析策略 具有MCC的个体，重点介绍跨条件和合伙人协同作用的代谢产物和途径 患有严重的疲劳，抑郁或焦虑及其群集，但患有 MCC最少或没有症状。与高症状相关的代谢物和代谢途径 严重程度将根据协变量（例如性别变量，年龄，慢性压力和）等协变量进行评估 歧视，饮食和药物。探索目的将进一步研究肠道的组成 微生物组作为这些符号的潜在协变量。我们的探索目标利用了我们学校的 微生物组研究的强度和将微生物组与这些符号联系起来的证据。行政 核心将成为中心的关键领导，并为其工作提供协调的支持 成员。行政核心的目的是： 目标1。建立和管理中心的基础设施，战略方向和计划，包括 确定能力建设的新机会和合作。 AIM 2。为三个核心以及中心的试点项目提供行政和财务监督以及 使试点项目调查人员能够制定一项研究计划。 目标3。促进中心资源和活动的传播以及与 中心科学主题。 目标4。实施形成性和总结性评估计划来评估产出，结果和影响 中心和执行努力来促进中心的可持续性。 管理核心是基于中心的Ninr Center Director逻辑模型结构的 可持续性和关键概念和战略管理的过程，并利用 在护理学校和埃默里大学中可用的特殊资源。行政 Core在该中心科学的相关领域中汇集了国内和国际知名的专家 专注于为海外中心活动提供必要的基础设施，并促进和加强 初级护士研究人员的合作，跨学科研究与发展。