Administrative Core

无机金属长期以来一直是新墨西哥州生物医学研究的重点，因为 该地区与采矿有关的金属污染物，以及我们对利用这种化学物质的兴趣 用于治疗或营养目的的金属的性质。我们在新墨西哥州有一个公认的需求 继续培训新的金属毒理学和致癌领域的研究人员以及基础研究人员 生物医学科学。新墨西哥大学金属生物学和医学中心(UNM CMBM) 将通过结合无机化学、分析化学和金属混合物的专业知识来解决这个问题 毒理学将为受指导的首席调查人员的研究增加复杂性和翻译价值 (MPI)。初级科学家将接受培训，重点是团队科学、指导和多学科 研究方法。为了确保中心和我们指导的绩效指标的成功，行政部门 CORE(AC)将提供管理和财务监督、指导和科学领导。长期的 我们中心的目标是发展智力、组织和物质基础设施，使其成为 国家认可的金属生物作用研究中心。本申请的目标是 是建立一个集中的AC，为科学目标提供管理和组织支持 并为我们的初级研究人员提供指导活动。因此，UNM CMBM AC有三个具体目标：AIM 1.为UNM CMBM提供科学指导和组织支持。咨询委员会的领导层将 推动科学目标，提供战略规划以及管理和财政监督。目标2.管理 MPI的职业发展、指导和科学培训。管理委员会将制定一套有效和 创新的指导策略，不仅满足被指导PI的需求，还满足其他中心的需求 会员和导师。目标3.促进金属生物学和金属研究的创新和拓展 医药。就预期结果而言，实现这些目标应该导致一个高水平的中心 机构能见度和可持续性，因为咨询委员会促进了一组协调良好的 互动和成功的调查人员。我们预计AC活动将有助于为 多个新计划，包括针对MPI的研究项目、机构资源和新的协作 向该中心的知名调查人员颁发奖项。预计这样的结果将产生重要的积极影响 影响并为才华横溢的调查人员进行协调和持续的努力奠定基础 关于环境污染物和金属利用问题的工作背景--生物学 推动医疗解决方案的互动。

Inorganic metals have long been a focus of biomedical research in New Mexico, owing both to the prevalence of mining-related metal contaminants in the region, as well as our interest in harnessing the chemical properties of metals for therapeutic or nutritional purposes. We have a recognized need in New Mexico to continue to train new researchers in the areas of metals toxicology and carcinogenesis, as well as in basic biomedical sciences. The University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) will address this by combining expertise in inorganic chemistry, analytical chemistry, and metal mixtures toxicology to add sophistication and translational value to the research of mentored principal investigators (mPIs). Junior scientists will be trained with an emphasis on team science mentoring and multidisciplinary approaches to research. In order to ensure success of the Center and our mentored PIs, the Administrative Core (AC) will provide the managerial and fiscal oversight, mentoring and scientific leadership. The long-term goal of our Center is to develop the intellectual, organizational and material infrastructure to become a nationally recognized center for research on the biological roles of metals. The goal of the present application is to establish a centralized AC that provides managerial and organizational support for the scientific objectives and mentoring activities for our junior researchers. The UNM CMBM AC therefore has three specific aims: Aim 1. Provide scientific direction and organizational support for the UNM CMBM. The leadership of the AC will drive scientific objectives, provide strategic planning as well as managerial and fiscal oversight. Aim 2. Manage career development, mentoring, and scientific training for mPIs. The AC will develop an effective and innovative mentoring strategy that addresses not only the needs of mentored PIs, but for other center members and mentors. Aim 3. Promote innovation and expansion of research on metals in biology and medicine. With respect to expected outcomes, achieving these aims should result in a Center with high institutional visibility and sustainability, as the AC fosters development of a well-coordinated group of interactive and successful investigators. We expect that AC activities will contribute to extramural funding of multiple new programs, including research projects for mPIs, institutional resources, and new collaborative awards to established investigators in the Center. Such outcomes are expected to have an important positive impact and provide the foundation for a concerted and sustained effort by talented investigators with different backgrounds working on problems related to environmental contaminants and utilization of metals-biological interactions to advance medical solutions.