Administrative Core

无机金属长期以来一直是新墨西哥州生物医学研究的焦点，这既是因为 该地区与采矿有关的金属污染物，以及我们对利用这种化学物质的兴趣， 用于治疗或营养目的的金属特性。我们在新墨西哥州有一个公认的需要， 继续培训金属毒理学和致癌作用领域的新研究人员， 生物医学科学新墨西哥州大学生物学和医学金属中心（UNM CMBM） 我将结合无机化学、分析化学和金属混合物方面的专业知识来解决这个问题 毒理学，以增加指导的主要研究人员的研究的复杂性和转化价值 （mPI）。初级科学家将接受培训，重点是团队科学指导和多学科 研究方法。为了确保中心和我们指导的PI的成功，行政 核心（AC）将提供管理和财政监督，指导和科学领导。长期 我们中心的目标是发展智力，组织和物质基础设施，成为一个 国家认可的金属生物作用研究中心。本申请的目的是 建立一个集中的AC，为科学目标提供管理和组织支持 和指导活动。因此，UNM CMBM AC有三个具体目标： 1.为UNM CMBM提供科学指导和组织支持。AC的领导层将 推动科学目标，提供战略规划以及管理和财政监督。目标二。管理 职业发展、指导和对mPI的科学培训。AC将制定有效的和 创新的指导策略，不仅满足受指导的PI的需求，也满足其他中心的需求 成员和导师。目标3：促进生物学中金属研究的创新和扩展， 药就预期成果而言，实现这些目标应使中心具有较高的 机构知名度和可持续性，因为AC促进了一个协调良好的 互动和成功的调查员。我们希望AC活动将有助于校外资金， 多个新项目，包括mPI的研究项目，机构资源和新的合作项目， 奖励给中心的既定调查人员。预计这些成果将产生重要的积极影响， 影响，并为有才华的调查人员的协调一致和持续努力提供基础， 从事与环境污染物和金属生物利用有关的问题的背景 促进医疗解决方案的互动。

Inorganic metals have long been a focus of biomedical research in New Mexico, owing both to the prevalence of mining-related metal contaminants in the region, as well as our interest in harnessing the chemical properties of metals for therapeutic or nutritional purposes. We have a recognized need in New Mexico to continue to train new researchers in the areas of metals toxicology and carcinogenesis, as well as in basic biomedical sciences. The University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) will address this by combining expertise in inorganic chemistry, analytical chemistry, and metal mixtures toxicology to add sophistication and translational value to the research of mentored principal investigators (mPIs). Junior scientists will be trained with an emphasis on team science mentoring and multidisciplinary approaches to research. In order to ensure success of the Center and our mentored PIs, the Administrative Core (AC) will provide the managerial and fiscal oversight, mentoring and scientific leadership. The long-term goal of our Center is to develop the intellectual, organizational and material infrastructure to become a nationally recognized center for research on the biological roles of metals. The goal of the present application is to establish a centralized AC that provides managerial and organizational support for the scientific objectives and mentoring activities for our junior researchers. The UNM CMBM AC therefore has three specific aims: Aim 1. Provide scientific direction and organizational support for the UNM CMBM. The leadership of the AC will drive scientific objectives, provide strategic planning as well as managerial and fiscal oversight. Aim 2. Manage career development, mentoring, and scientific training for mPIs. The AC will develop an effective and innovative mentoring strategy that addresses not only the needs of mentored PIs, but for other center members and mentors. Aim 3. Promote innovation and expansion of research on metals in biology and medicine. With respect to expected outcomes, achieving these aims should result in a Center with high institutional visibility and sustainability, as the AC fosters development of a well-coordinated group of interactive and successful investigators. We expect that AC activities will contribute to extramural funding of multiple new programs, including research projects for mPIs, institutional resources, and new collaborative awards to established investigators in the Center. Such outcomes are expected to have an important positive impact and provide the foundation for a concerted and sustained effort by talented investigators with different backgrounds working on problems related to environmental contaminants and utilization of metals-biological interactions to advance medical solutions.