New Mexico Center for Metals in Biology and Medicine - Equipment Supplement
新墨西哥生物和医学金属中心 - 设备补充
基本信息
- 批准号:10395875
- 负责人:
- 金额:$ 25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:Analytical ChemistryBindingBiologicalBiological AssayBiological MarkersBiologyBiomedical ResearchClinicalCommunitiesComplementCore FacilityDNA DamageDevelopmentEquipmentFundingHealthHealth SciencesHigh PrevalenceInjectionsInterventionKnowledgeLaboratoriesLeadMedicineMetalsMethodsMiningMolecular AnalysisNational Institute of General Medical SciencesNew MexicoNutritionalOutcomePeptidesPopulationProductivityProtein AnalysisPublic HealthResearchResourcesSamplingSystemTechniquesTherapeuticUniversitiesbasechemical propertycost effectiveequipment acquisitionimprovedinnovationinstrumentinstrumentationinterestlipidomicsmembermetabolomicsmetallicitysmall molecule
项目摘要
Administrative Suppl. for Equipment Purchases for NIGMS-funded Center and Core Facilities NOT-GM-21-029
Summary Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high
prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for
Metals in Biology and Medicine (UNM CMBM), our main focus is on both studying adverse health outcomes of
metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional
purposes. Detailed knowledge of molecular interactions between metallic species and biomolecules can lead
to clinical and population-level interventions to improve public health. Towards this end, we have established a
new Integrative Molecular Analysis Core (IMAC) to provide members, and the UNM Health Sciences Center
campus, with cutting edge analytical chemistry instrumentation and techniques. is launching, still in its first
year, and seeing a surge of user interest and activity. In responding to needs of our research community,
several specific analytical applications require additional specialized instrumentation for high-accuracy small
molecule quantitation have been discussed. To provide the membership with a workhorse machine that can
handle targeted metabolomic and lipidomic assays, as well as examine DNA damage, oxidative biomarkers,
and metal-associated biomolecules, the Sciex 5500+ Triple QuadTM offers a superb cost-effective system to
meet our diverse quantitation needs. Featuring a high level of sensitivity, selectivity and linear dynamic range,
it allows for the most demanding quantitation analyses, such as challenges of severely interfered low-level
trace quantification that are commonly encountered during analysis of specific metabolites and biomarkers in
biological and environmental samples. Triple Quad LC-MS/MS systems deliver superior quantitative results in
a single injection workflow. By offering robust targeted quantitative analysis of known small molecules such as
metabolites, biomarkers and peptides of interests, it is a highly beneficial addition and expansion to our
Orbitrap LC-HRMS platform that is preferentially used for non-targeted protein analysis. This state-of-the-art
system is the first of its kind on our HSC campus. It will complement our current MS systems to provide new
and extended applications for our user base. Moreover, faster and more sensitive instrument will help with our
constant development of innovative bioanalytical methods to meet new research needs of our users.
Establishing this capacity at UNM will certainly meet the needs of a wider audience and expand the value of
our IMAC for the UNM HSC. Therefore, the 5500+ system will enhance our user access to and impact of the
resource, improve the productivity and efficiency in the laboratory, and help sustain the Core.
NIGMS资助的中心和核心设施设备采购行政补充文件NOT-GM-21-029
摘要无机金属长期以来一直是新墨西哥州生物医学研究的焦点,
该区域与采矿有关的金属污染物普遍存在。在新墨西哥州大学的
金属在生物学和医学(UNM CMBM),我们的主要重点是研究不良的健康结果,
金属污染物以及利用金属的化学性质用于治疗和营养
目的对金属物种和生物分子之间分子相互作用的详细了解可以导致
临床和人口层面的干预措施,以改善公共卫生。为此,我们设立了一个
新的综合分子分析核心(IMAC)提供成员,和UNM健康科学中心
校园,与尖端的分析化学仪器和技术。正在发射,仍然是第一个
这一年,用户的兴趣和活动激增。为了满足我们研究界的需求,
一些特定的分析应用需要额外的专用仪器,
分子定量进行了讨论。为会员提供一台能够
处理靶向代谢组学和脂质组学分析,以及检查DNA损伤,氧化生物标志物,
Sciex 5500+ Triple QuadTM提供了一个极具成本效益的系统,
满足我们多样化的定量需求。具有高水平的灵敏度、选择性和线性动态范围,
它允许最苛刻的定量分析,如严重干扰的低水平的挑战,
在分析特定代谢物和生物标志物的过程中经常遇到的痕量定量,
生物和环境样本。三重四重LC-MS/MS系统提供上级定量结果,
一个单一的注射工作流程。通过提供已知小分子的稳健的靶向定量分析,
代谢物,生物标志物和感兴趣的肽,这是一个非常有益的补充和扩展,我们的
Orbitrap LC-HRMS平台,优先用于非靶向蛋白质分析。这种最先进的
系统是我们HSC校园中的第一个同类系统。它将补充我们目前的MS系统,
和扩展的应用程序。此外,更快、更灵敏的仪器将有助于我们
不断开发创新的生物分析方法,以满足用户的新研究需求。
在联合国墨西哥大学建立这一能力肯定会满足更广泛受众的需求,并扩大
我们为UNM HSC设计的IMAC因此,5500+系统将增强我们的用户访问和影响力,
资源,提高实验室的生产力和效率,并帮助维持核心。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Matthew J Campen其他文献
Bioaccumulation of Microplastics in Decedent Human Brains Assessed by Pyrolysis Gas Chromatography-Mass Spectrometry
通过热解气相色谱-质谱法评估死者大脑中微塑料的生物累积
- DOI:
10.21203/rs.3.rs-4345687/v1 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Matthew J Campen;Alex Nihart;Marcus A Garcia;Rui Liu;Marian Olewine;Eliseo F Castillo;Barry Bleske;Justin Scott;Tamara Howard;Jorge Gonzalez;Natalie Adolphi;Daniel F Gallego;E. Hayek - 通讯作者:
E. Hayek
Matthew J Campen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Matthew J Campen', 18)}}的其他基金
Acceleration of Circulatory and Neurological Aging due to Wildfire Exposures
野火暴露导致循环系统和神经系统老化加速
- 批准号:
10544543 - 财政年份:2022
- 资助金额:
$ 25万 - 项目类别:
Acceleration of Circulatory and Neurological Aging due to Wildfire Exposures
野火暴露导致循环系统和神经系统老化加速
- 批准号:
10363056 - 财政年份:2022
- 资助金额:
$ 25万 - 项目类别:
University of New Mexico Center for Metals in Biology and Medicine
新墨西哥大学生物和医学金属中心
- 批准号:
10629336 - 财政年份:2020
- 资助金额:
$ 25万 - 项目类别:
SARS-CoV-2 Genomic Surveillance and Epidemiology in New Mexico
新墨西哥州 SARS-CoV-2 基因组监测和流行病学
- 批准号:
10381051 - 财政年份:2020
- 资助金额:
$ 25万 - 项目类别:
University of New Mexico Center for Metals in Biology and Medicine
新墨西哥大学生物和医学金属中心
- 批准号:
10408025 - 财政年份:2020
- 资助金额:
$ 25万 - 项目类别:
SARS-CoV-2 Genomic Surveillance and Epidemiology in New Mexico
新墨西哥州 SARS-CoV-2 基因组监测和流行病学
- 批准号:
10594348 - 财政年份:2020
- 资助金额:
$ 25万 - 项目类别:
University of New Mexico Center for Metals in Biology and Medicine
新墨西哥大学生物和医学金属中心
- 批准号:
10202647 - 财政年份:2020
- 资助金额:
$ 25万 - 项目类别:
相似国自然基金
帽结合蛋白(cap binding protein)调控乙烯信号转导的分子机制
- 批准号:32170319
- 批准年份:2021
- 资助金额:58.00 万元
- 项目类别:面上项目
帽结合蛋白(cap binding protein)调控乙烯信号转导的分子机制
- 批准号:
- 批准年份:2021
- 资助金额:58 万元
- 项目类别:
ID1 (Inhibitor of DNA binding 1) 在口蹄疫病毒感染中作用机制的研究
- 批准号:31672538
- 批准年份:2016
- 资助金额:62.0 万元
- 项目类别:面上项目
番茄EIN3-binding F-box蛋白2超表达诱导单性结实和果实成熟异常的机制研究
- 批准号:31372080
- 批准年份:2013
- 资助金额:80.0 万元
- 项目类别:面上项目
P53 binding protein 1 调控乳腺癌进展转移及化疗敏感性的机制研究
- 批准号:81172529
- 批准年份:2011
- 资助金额:58.0 万元
- 项目类别:面上项目
DBP(Vitamin D Binding Protein)在多发性硬化中的作用和相关机制的蛋白质组学研究
- 批准号:81070952
- 批准年份:2010
- 资助金额:35.0 万元
- 项目类别:面上项目
研究EB1(End-Binding protein 1)的癌基因特性及作用机制
- 批准号:30672361
- 批准年份:2006
- 资助金额:24.0 万元
- 项目类别:面上项目
相似海外基金
I-Corps: Translation Potential of Real-time, Ultrasensitive Electrical Transduction of Biological Binding Events for Pathogen and Disease Detection
I-Corps:生物结合事件的实时、超灵敏电转导在病原体和疾病检测中的转化潜力
- 批准号:
2419915 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
Modelling drug binding to biological ion channels
模拟药物与生物离子通道的结合
- 批准号:
2747257 - 财政年份:2022
- 资助金额:
$ 25万 - 项目类别:
Studentship
Elucidation of biological functions of the NCBP3 RNA-binding protein using a novel mutant mouse strain
使用新型突变小鼠品系阐明 NCBP3 RNA 结合蛋白的生物学功能
- 批准号:
22K06065 - 财政年份:2022
- 资助金额:
$ 25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identifying binding partners, biological substrates and antisense oligonucleotides regulating expression of short and long ACE2.
识别调节短和长 ACE2 表达的结合伴侣、生物底物和反义寡核苷酸。
- 批准号:
BB/V019848/1 - 财政年份:2021
- 资助金额:
$ 25万 - 项目类别:
Research Grant
Structure and function of pufferfish toxin, tetrodotoxin, binding proteins as biological defense agent
河豚毒素、河豚毒素、结合蛋白作为生物防御剂的结构和功能
- 批准号:
19K06241 - 财政年份:2019
- 资助金额:
$ 25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Investigating a biological specificity conundrum: the role of dynamics in transcription factor binding
研究生物特异性难题:动力学在转录因子结合中的作用
- 批准号:
406750 - 财政年份:2018
- 资助金额:
$ 25万 - 项目类别:
Studentship Programs
The molecular and biological roles of growth inhibiting chromatin binding proteins
生长抑制染色质结合蛋白的分子和生物学作用
- 批准号:
nhmrc : GNT1143612 - 财政年份:2018
- 资助金额:
$ 25万 - 项目类别:
Project Grants
Electrical Detection of Small Molecule Binding to Biological Receptors using Organic Thin Film Transistors : A new approach for label free assays
使用有机薄膜晶体管对小分子与生物受体结合的电检测:一种无标记测定的新方法
- 批准号:
133593 - 财政年份:2018
- 资助金额:
$ 25万 - 项目类别:
Feasibility Studies
Biological effect and preventive method for human serum albumin binding to transboundary air borne PM2.5.
人血清白蛋白与跨境空气PM2.5结合的生物学效应及预防方法。
- 批准号:
18H03039 - 财政年份:2018
- 资助金额:
$ 25万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The molecular and biological roles of growth inhibiting chromatin binding proteins
生长抑制染色质结合蛋白的分子和生物学作用
- 批准号:
nhmrc : 1143612 - 财政年份:2018
- 资助金额:
$ 25万 - 项目类别:
Project Grants