University of New Mexico Center for Metals in Biology and Medicine

无机金属长期以来一直是新墨西哥州生物医学研究的焦点，这是由于 与采矿有关的金属污染物。在新墨西哥州大学生物学金属中心 和医学（UNM CMBM），我们的主要重点将是研究不良健康结果（包括 癌症，肺，神经系统和其他疾病）的金属污染物，以及利用 用于治疗和营养目的的金属的化学性质。详细了解分子 金属物质和生物分子之间的相互作用可以导致临床和人群水平的干预 来改善公众健康。虽然重金属和过渡金属在医学和毒理学上都表现出 然而，由于这些特征，分子和细胞的相互作用往往没有得到充分的理解。UNM CMBM 将结合联合收割机在无机化学、分析化学和金属混合物毒理学方面的专业知识， 对指导的主要研究者（mPI）的研究的复杂性和转化价值。最近 导师团队成员和mPI的发现强调了对分子生物学更深入的需求。 在研究金属与生物分子靶点的相互作用方面的探索，因为这种详细的理解允许 改进受体靶向（就药物而言）或创新干预措施（就 环境危害）。通过提供知识专长和先进的仪器， 研究工作，我们将提高他们的资金机会和职业发展，以充分的独立性。 在我们的计划导师有一个成功的初级教师职业发展的强大历史，我们 将在P20中心的框架内，通过推广多学科的关键概念， 团队科学和转化研究方法。我们的长期目标是建立一个全国性的 公认的资金充足的研究人员进行金属毒理学创新研究的计划， 生物医学对新墨西哥州和西南社区产生积极影响。我们将实现这一目标 通过以下三个具体目标实现目标：目标1。建立一个强大的独立调查员社区 与医学和生物学中的金属相关的共同研究目标。目标2.建立集中研究 通过整合现有的联合国特派团-卫生科学中心，建立综合分子分析核心设施 科学资源和建设创新设施，以改善生物分析化学研究培训， 提高mPI的生产力，并提高我们研究所的研究质量和深度。目标3：创造一个独特 “生物学和医学中的金属”计划，具有明确的T0-T4翻译价值。成功 该中心的实施将导致独立的研究经费在新墨西哥州的增长，特别是在 初级调查员实现独立的职业目标。我们项目的结果具有明确的临床和 公共卫生福利的人口和社区在西南部，包括许多原住民 美国人口不成比例地受到采矿作业遗留废物的影响。 1

Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, and other disorders) of metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional purposes. Detailed knowledge of molecular interactions between metallic species and biomolecules can lead to clinical and population-level interventions to improve public health. While heavy and transition metals exhibit both medical and toxicological characteristics, the molecular and cellular interactions are often inadequately understood. The UNM CMBM will combine expertise in inorganic chemistry, analytical chemistry, and metal mixtures toxicology to add sophistication and translational value to the research of mentored principal investigators (mPIs). Recent discoveries from members of the mentorship team and mPIs highlight the need for greater depth of molecular inquiry in studying metal interactions with biomolecular targets, as such detailed understanding permits improvements in receptor targeting (in the case of medicines) or innovative interventions (in the case of environmental hazards). By providing intellectual expertise and advanced instrumentation to aid the mPIs' research endeavors, we will enhance their funding opportunities and career progression to full independence. The mentors in our program have a strong history of successful junior faculty career development, which we will further enhance within the framework of this P20 Center by promoting the key concepts of multidisciplinary team science and translational research approaches. Our long-term goal is to establish a nationally recognized program of well-funded researchers conducting innovative research on metals toxicology and biomedicine that has positive impacts on New Mexican and Southwestern communities. We will achieve this goal through the following three specific aims: Aim 1. Create a strong community of independent investigators with common research goals related to metals in medicine and biology. Aim 2. Establish centralized research Integrative Molecular Analysis Core Facility by integrating existing UNM-Health Science Center (HSC) scientific resources and building innovative facilities to improve bioanalytical chemistry research training and productivity for mPIs, as well as to bolster research quality and depth for our institute. Aim 3. Create a unique “Metals in Biology and Medicine” program that has clear T0-T4 translational value. The successful implementation of this Center will lead to growth in independent research funding at UNM, especially among junior investigators achieving independent career goals. The outcomes of our program have clear clinical and public health benefit to populations and communities in the southwest, including the numerous Native American populations disproportionately impacted by legacy waste from mining operations. 1