University of New Mexico Center for Metals in Biology and Medicine

新墨西哥大学生物和医学金属中心

• 批准号: 10202647
• 负责人: Matthew J Campen
• 金额: $ 227.72万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10202647
• 关键词: Analytical Chemistry; Area; Binding; Biochemistry; Biology; Biomedical Research; Cancer Biology; Centers of Research Excellence; Characteristics; Chemistry; Clinical; Clinical Sciences; Communities; Community Health; Community Outreach; Complex; Computers and Advanced Instrumentation; Core Facility; Development; Disease; Drug Delivery Systems; Environmental Hazards; Environmental Health; Exhibits; Extramural Activities; Faculty; Funding; Funding Opportunities; Goals; Growth; Health; Health Benefit; Health Sciences; Heavy Metals; High Prevalence; Home; Human; Immunology; Inorganic Chemistry; Institutes; Intervention; Investigation; Knowledge; Lead; Leadership; Link; Lung; Malignant Neoplasms; Medical; Medicine; Mentors; Mentorship; Metals; Mexican; Mining; Molecular; Molecular Analysis; Native Americans; Neurologic; Neurosciences; New Mexico; Nutritional; Outcome; Patients; Physiology; Play; Population; Prevalence; Principal Investigator; Productivity; Property; Public Health; Recording of previous events; Research; Research Personnel; Research Training; Resources; Risk; Role; Science; Scientist; Services; Southwestern United States; Therapeutic; Tissue Model; Toxicology; Toxin; Training; Transition Elements; Translational Research; Underserved Population; Universities; Work; biological systems; career; career development; chemical property; community intervention; environmental toxicology; global health; improved; innovation; member; metallicity; multidisciplinary; novel; nutrition; operation; programs; receptor; wasting

Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, and other disorders) of metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional purposes. Detailed knowledge of molecular interactions between metallic species and biomolecules can lead to clinical and population-level interventions to improve public health. While heavy and transition metals exhibit both medical and toxicological characteristics, the molecular and cellular interactions are often inadequately understood. The UNM CMBM will combine expertise in inorganic chemistry, analytical chemistry, and metal mixtures toxicology to add sophistication and translational value to the research of mentored principal investigators (mPIs). Recent discoveries from members of the mentorship team and mPIs highlight the need for greater depth of molecular inquiry in studying metal interactions with biomolecular targets, as such detailed understanding permits improvements in receptor targeting (in the case of medicines) or innovative interventions (in the case of environmental hazards). By providing intellectual expertise and advanced instrumentation to aid the mPIs' research endeavors, we will enhance their funding opportunities and career progression to full independence. The mentors in our program have a strong history of successful junior faculty career development, which we will further enhance within the framework of this P20 Center by promoting the key concepts of multidisciplinary team science and translational research approaches. Our long-term goal is to establish a nationally recognized program of well-funded researchers conducting innovative research on metals toxicology and biomedicine that has positive impacts on New Mexican and Southwestern communities. We will achieve this goal through the following three specific aims: Aim 1. Create a strong community of independent investigators with common research goals related to metals in medicine and biology. Aim 2. Establish centralized research Integrative Molecular Analysis Core Facility by integrating existing UNM-Health Science Center (HSC) scientific resources and building innovative facilities to improve bioanalytical chemistry research training and productivity for mPIs, as well as to bolster research quality and depth for our institute. Aim 3. Create a unique “Metals in Biology and Medicine” program that has clear T0-T4 translational value. The successful implementation of this Center will lead to growth in independent research funding at UNM, especially among junior investigators achieving independent career goals. The outcomes of our program have clear clinical and public health benefit to populations and communities in the southwest, including the numerous Native American populations disproportionately impacted by legacy waste from mining operations. 1

无机金属长期以来一直是新墨西哥州生物医学研究的焦点，因为 该地区与采矿有关的金属污染物。新墨西哥大学生物学金属中心 和医学（UNM CMBM），我们的主要重点将是研究不良健康结果（包括 金属污染物的癌症、肺癌、神经系统疾病和其他疾病）以及利用 用于治疗和营养目的的金属的化学性质。详细的分子知识 金属物质和生物分子之间的相互作用可以导致临床和人群水平的干预 改善公共卫生。虽然重金属和过渡金属在医学和毒理学方面都表现出 特征、分子和细胞相互作用往往未被充分理解。新墨西哥州 CMBM 将结合无机化学、分析化学和金属混合物毒理学方面的专业知识来添加 指导主要研究者 (mPI) 研究的复杂性和转化价值。最近的 导师团队成员和 mPI 的发现凸显了对更深入的分子研究的需要。 研究金属与生物分子靶标相互作用的探究，因为详细的理解允许 受体靶向的改进（就药物而言）或创新干预措施（就药物而言） 环境危害）。通过提供知识专长和先进仪器来帮助 mPI 研究努力，我们将增加他们的资助机会和职业发展，直至完全独立。 我们项目中的导师拥有成功的初级教师职业发展历史，我们 将通过推广多学科的关键概念，在 P20 中心的框架内进一步加强 团队科学和转化研究方法。我们的长远目标是建立全国性的 由资金充足的研究人员组成的公认计划，进行金属毒理学和 对新墨西哥州和西南部社区产生积极影响的生物医学。我们将实现这一目标 通过以下三个具体目标来实现目标： 目标 1. 创建一个强大的独立调查人员社区 具有与医学和生物学金属相关的共同研究目标。目标 2. 建立集中研究 整合现有新墨西哥大学健康科学中心 (HSC) 的综合分子分析核心设施 科学资源和建设创新设施，以改善生物分析化学研究培训和 提高 mPI 的生产力，并提高我们研究所的研究质量和深度。目标 3. 创造独特的 “金属在生物学和医学中的应用”项目具有明确的T0-T4转化价值。成功者 该中心的实施将导致新墨西哥大学独立研究经费的增长，特别是在 初级研究者实现独立的职业目标。我们的计划的结果具有明确的临床和 为西南地区的人口和社区（包括众多原住民）带来公共卫生益处 美国人口受到采矿作业遗留废物的影响尤为严重。 1