Neural processes of speech planning

言语规划的神经过程

• 批准号: 10202553
• 负责人: Ayoub Daliri
• 金额: $ 14.5万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-03 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202553
• 关键词: Acoustics; Adult; Auditory; Auditory system; Characteristics; Childhood; Clinical; Data; Detection; Development; Electroencephalography; Electrophysiology (science); Event; Foundations; Frequencies; Individual; Knowledge; Lead; Learning; Link; Masks; Measures; Methods; Modeling; Monitor; Motor; Movement; Neuraxis; Neurobiology; Noise; Process; Production; Reporting; Research; Sensory; Speech; Speech Acoustics; Speech Disorders; Speech Sound; Stimulus; Stuttering; System; Techniques; Testing; Time; Training; auditory feedback; base; follow-up; innovation; neurofeedback; neuromechanism; novel therapeutics; programs; relating to nervous system; response; sound; speech accuracy; theories

PROJECT SUMMARY The central nervous system (CNS) closely monitors auditory feedback during speech production. This monitoring process is critical for learning to produce speech and maintaining the speech production system. Moreover, stuttering and several speech disorders are associated with deficits in monitoring. Thus, understanding neural mechanisms of speech monitoring is critical for development and refinement of theories of speech production and stuttering, as well as, for development of theory-driven treatments. Current models of speech have focused entirely on monitoring processes during speech production and do not explain if and how the CNS optimizes the auditory system prior to speech initiation for speech monitoring. Such modulatory mechanisms are especially fundamental to the understanding of stuttering, as most stuttering events occur on the initial sound/syllable of words, highlighting deficient preparatory mechanisms in stuttering individuals. This program of research aims at elucidating predictive modulatory mechanisms occurring before speech initiation. We hypothesize that the CNS uses an active process in which motor predictions optimally adjust the auditory system prior to speech initiation for effective speech monitoring. By combining electroencephalography (EEG) and speech acoustics in the context of innovative experimental paradigms, we propose a program of research to study three main aspects of the phenomenon of pre-speech modulation that will have immediate theoretical and long-term clinical implications. The proposed studies will a) substantially expand our knowledge of predictive mechanisms that optimize speech monitoring, and b) inform theories of speech production by providing a (currently missing) account of how the CNS optimizes the auditory system to accomplish effective speech monitoring. Importantly, given our previous reports of lack of pre-speech modulation in individuals who stutter, this program of research will provide a strong foundation for a follow-up R01 proposal to examine contributions of pre-speech sensory modulation in neurobiological bases of stuttering. Finally, our findings will pave the way for completely novel therapeutics techniques (e.g., neuro-feedback training and noninvasive neuro-stimulation) that specifically target pre-speech modulation as a promising neural target.

项目概要 中枢神经系统（CNS）密切监视言语产生过程中的听觉反馈。这 监控过程对于学习产生语音和维护语音产生系统至关重要。 此外，口吃和一些言语障碍也与监控缺陷有关。因此， 理解语音监控的神经机制对于理论的发展和完善至关重要 言语产生和口吃的研究，以及理论驱动治疗的发展。目前的型号 语音完全集中于语音生成过程中的监控过程，并且没有解释是否以及如何进行 中枢神经系统在言语启动之前优化听觉系统以进行言语监控。这样的调节 机制对于理解口吃尤其重要，因为大多数口吃事件发生在 单词的初始声音/音节，突出显示口吃个体的准备机制不足。这 该研究计划旨在阐明在言语开始之前发生的预测调节机制。 我们假设中枢神经系统使用一个主动过程，其中运动预测可以最佳地调整听觉 系统在语音启动之前进行有效的语音监控。结合脑电图 (EEG) 和语音声学在创新实验范式的背景下，我们提出了一个研究计划 研究预语音调制现象的三个主要方面，这将具有直接的理论意义 和长期的临床影响。拟议的研究将a）大大扩展我们的知识 优化语音监控的预测机制，以及 b）通过以下方式为语音产生理论提供信息： 提供（目前缺失的）中枢神经系统如何优化听觉系统以实现有效的说明 语音监控。重要的是，鉴于我们之前的报告称，以下人群缺乏言语前调节： 口吃，这个研究计划将为后续 R01 提案的审查提供坚实的基础 言语前感觉调节在口吃的神经生物学基础中的贡献。最后，我们的研究结果将 为全新的治疗技术铺平道路（例如神经反馈训练和非侵入性治疗） 神经刺激）专门针对语音前调制作为有前途的神经目标。