Clinical and Translational Core (Core C)
临床和转化核心(核心 C)
基本信息
- 批准号:10203940
- 负责人:
- 金额:$ 23.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAmericanAwardBioethicsBioethics ConsultantsBioinformaticsBiological MarkersBiological Specimen BanksCardiovascular DiseasesCessation of lifeChronic Kidney FailureClinicalClinical InvestigatorClinical ResearchClinical TrialsCohort StudiesCollaborationsCommunitiesComputerized Medical RecordDataData AnalysesData CollectionDevelopmentDisciplineEnd stage renal failureEnsureEnvironmentEpidemiologyEthicistsEthicsFinancial HardshipFundingGoalsHealthHealth Care CostsHealthcare SystemsHuman Subject ResearchHumanitiesImpairmentIndividualInstitutionInvestmentsKidneyKidney DiseasesLeadLocationLongevityMedicalMethodologyMethodsModalityNephrologyObservational StudyOutcomeParticipantPathogenesisPatient Outcomes AssessmentsPatient RightsPatientsPhenotypePhysiologicalPilot ProjectsPositioning AttributePre-Clinical ModelPreventionProcessProtocols documentationProviderQuality ControlQuality of lifeResearchResearch DesignResearch InfrastructureResearch PersonnelResearch SupportResourcesRetrievalScientific InquirySecurityServicesSpeedSystemTalentsTherapeuticTranslatingTranslational ResearchTranslationsUniversitiesWorkadverse outcomebasebiobankbiomedical informaticsclinical translationclinically relevantcommunity based participatory researchcommunity based researchcomorbiditydata managementdata repositorydesignethnic diversityexperiencefirst-in-humanhigh riskimprovedinclusion criteriamodel developmentmultidisciplinarynovelnovel therapeuticspatient populationpre-clinicalprematureracial diversityresearch and developmentresearch studysoundstatisticsstudy populationtherapeutic development
项目摘要
PROJECT SUMMARY TO CLINICAL AND TRANSLATION CORE
Kidney diseases predispose affected individuals to high rates of end stage renal disease (ESRD),
cardiovascular disease (CVD) and premature death. With nearly 30 million Americans estimated to have
chronic kidney disease, the healthcare costs are tremendous. Identification of novel mechanisms for the
pathogenesis of kidney diseases and related complications is urgently needed to improve adverse clinical
outcomes and to reduce the financial burden on the US healthcare system. The George M. O'Brien Kidney
Research Core Center at Northwestern University (NU-GoKIDNEY) will promote and support research
into the discovery of novel therapeutics that will transform the prevention and treatment of kidney
diseases and eventually lead to cures. The Center will join basic and clinical investigators to conduct
translational research focused on the discovery of novel therapeutic modalities for patients with
kidney diseases. Research catalyzed by the Preclinical Models Core and the Therapeutics Development
Core will lead to discoveries of novel therapies, which will be translated into patients through the activities of
the Clinical and Translational Core. The Core Leaders will work together to synergistically advance the
Center’s chief goal of finding new treatments that will improve the lives of patients with kidney diseases. The
Clinical and Translational Core will provide a centralized environment, essential resources and multi-
disciplinary expertise to safely and ethically translate and target the discoveries identified by the Preclinical
Model and Therapeutics Development Cores into the right patient population. We will efficiently connect
investigators with: (1) the most appropriate components of the existing clinical research infrastructure; (2)
relevant analytic experts; (3) well-matched talent in methods not commonly used in nephrology research, (4)
unique data and biosample repositories; and (5) community-based research study participants and leaders in
bioethics and medical humanities. Our goals are: (1) to enhance the integration of institutional strengths in
clinical research; (2) to encourage cross-disciplinary collaboration within and between the Cores; (3) to
introduce new disciplines into the field of kidney diseases research; (4) to improve the ability of investigators to
phenotype participants through access to data and biosample repositories; and (5) to enrich the experience of
study participants by enlisting involvement of bioethicists, study participants and community providers in the
development of research protocols. By leveraging our strong institutional environment, existing resources and
multidisciplinary expertise, the Clinical and Translational Core will accelerate the translation of preclinical
discoveries into meaningful health improvements for patients with kidney diseases.
临床和翻译核心的项目总结
肾脏疾病使受影响的个体易患终末期肾脏疾病(ESRD),
心血管疾病(CVD)和过早死亡。估计有近3000万美国人
慢性肾病的医疗费用是巨大的。确定新的机制,
肾脏疾病及其相关并发症的发病机制,迫切需要改善不良的临床
以减轻美国医疗保健系统的财政负担。该乔治M。奥布莱恩肾
西北大学研究核心中心(NU-GoKIDNEY)将促进和支持研究
发现新的治疗方法,将改变肾脏疾病的预防和治疗,
疾病,并最终治愈。该中心将联合基础和临床研究人员,
转化研究的重点是发现新的治疗方式的患者
肾脏疾病由临床前模型核心和治疗药物开发催化的研究
核心将导致新疗法的发现,这些新疗法将通过以下活动转化为患者
临床和翻译核心。核心领导人将共同努力,协同推进
该中心的主要目标是寻找新的治疗方法,改善肾病患者的生活。的
临床和翻译核心将提供一个集中的环境,必要的资源和多
学科专业知识,以安全和道德地转化和靶向临床前研究所确定的发现
模型和治疗药物开发核心进入正确的患者人群。我们将有效地连接
研究者:(1)现有临床研究基础设施的最适当组成部分;(2)
相关分析专家;(3)在肾脏病学研究中不常用的方法方面具有匹配的人才,(4)
独特的数据和生物样本储存库;(5)社区研究参与者和领导者,
生物伦理学和医学人文学。我们的目标是:(1)加强机构优势的整合,
临床研究;(2)鼓励核心内部和之间的跨学科合作;(3)
在肾脏病研究领域引入新的学科;(4)提高研究者的能力,
表型参与者通过访问数据和生物样品储存库;(5)丰富的经验,
研究参与者通过招募生物伦理学家,研究参与者和社区提供者参与,
制定研究方案。通过利用我们强大的体制环境、现有资源和
多学科专业知识,临床和翻译核心将加速临床前翻译
这些发现对肾脏疾病患者的健康有意义的改善。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Tamara Isakova其他文献
Tamara Isakova的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Tamara Isakova', 18)}}的其他基金
Mentored patient-oriented research of novel mechanisms for cardiovascular disease in patients with chronic kidney disease
指导以患者为中心的慢性肾病患者心血管疾病新机制的研究
- 批准号:
10544535 - 财政年份:2020
- 资助金额:
$ 23.22万 - 项目类别:
Mentored patient-oriented research of novel mechanisms for cardiovascular disease in patients with chronic kidney disease
指导以患者为中心的慢性肾病患者心血管疾病新机制的研究
- 批准号:
10386759 - 财政年份:2020
- 资助金额:
$ 23.22万 - 项目类别:
Novel Diagnostics and Therapeutic Targets for Calcification in CKD
CKD 钙化的新诊断和治疗靶点
- 批准号:
9978819 - 财政年份:2016
- 资助金额:
$ 23.22万 - 项目类别:
Novel Diagnostics and Therapeutic Targets for Calcification in CKD
CKD 钙化的新诊断和治疗靶点
- 批准号:
9157901 - 财政年份:2016
- 资助金额:
$ 23.22万 - 项目类别:
Impact of phosphate and FGF23 reduction on intermediate end points in CKD
磷酸盐和 FGF23 减少对 CKD 中间终点的影响
- 批准号:
8748271 - 财政年份:2014
- 资助金额:
$ 23.22万 - 项目类别:
相似海外基金
Research Initiation Award: De/Reconstructing African-American Preservice Teachers' Mathematics Identities and Visions of Mathematics Teaching for Equity
研究启动奖:解/重构非裔美国职前教师的数学身份和数学教学公平愿景
- 批准号:
1955792 - 财政年份:2020
- 资助金额:
$ 23.22万 - 项目类别:
Standard Grant
Scholars Award: Bringing to Light a Court Case over the Teaching of Evolution in American Schools that Preceded the Scopes Trial
学者奖:揭露斯科普斯审判之前美国学校进化论教学的法庭案件
- 批准号:
1656146 - 财政年份:2017
- 资助金额:
$ 23.22万 - 项目类别:
Standard Grant
Scholars Award: Calculating the American Way: Computing Productivity in Transatlantic Relations
学者奖:计算美国方式:跨大西洋关系中的计算生产力
- 批准号:
1457134 - 财政年份:2015
- 资助金额:
$ 23.22万 - 项目类别:
Standard Grant
Individual PAESMEM Award: Marigold Linton, Director of American Indian Outreach
个人 PAESMEM 奖:Marigold Linton,美国印第安人外展部主任
- 批准号:
0931675 - 财政年份:2011
- 资助金额:
$ 23.22万 - 项目类别:
Standard Grant
Scholar's Award: Chinese/American Scientists: Transnational Science during the Cold War and Beyond
学者奖:中国/美国科学家:冷战及其后的跨国科学
- 批准号:
1026879 - 财政年份:2010
- 资助金额:
$ 23.22万 - 项目类别:
Continuing Grant
Scholars Award: The Appropriate Technology Movement in American Political Culture
学者奖:美国政治文化中的适当技术运动
- 批准号:
0822907 - 财政年份:2008
- 资助金额:
$ 23.22万 - 项目类别:
Standard Grant
Scholars' Award: Supermarket USA: Food, Technology, and Power in the American Century
学者奖:美国超市:美国世纪的食品、技术和电力
- 批准号:
0646662 - 财政年份:2007
- 资助金额:
$ 23.22万 - 项目类别:
Standard Grant
Support of American Scholars in the Natural and Social Sciences in Collaborative Research in India, Award in IndianCurrency
美国自然科学和社会科学学者在印度合作研究的支持,印度货币奖
- 批准号:
9202465 - 财政年份:1992
- 资助金额:
$ 23.22万 - 项目类别:
Continuing Grant
Support of American Scholars in the Natural and Social Sciences in Collaborative Research in #India Award in U.S. and Indian Currencies
美国自然科学和社会科学学者对合作研究的支持
- 批准号:
9002208 - 财政年份:1990
- 资助金额:
$ 23.22万 - 项目类别:
Continuing Grant
Collaboration of Indian and American Research Scholars in the Natural and Social Sciences, Award in US and Indian Currencies
印度和美国自然科学和社会科学研究学者的合作,以美国和印度货币颁发奖项
- 批准号:
8803200 - 财政年份:1988
- 资助金额:
$ 23.22万 - 项目类别:
Continuing Grant