Routing of SPW-R content via distinct hippocampal output pathways
通过不同的海马输出途径进行 SPW-R 内容的路由
基本信息
- 批准号:10202754
- 负责人:
- 金额:$ 44.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-25 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAnatomyBehaviorBehavioralCalciumCrystallizationDependenceDorsalElectrophysiology (science)EmotionalEquine muleEventHeadHeterogeneityHippocampus (Brain)ImageLabelLearningLocationMediatingMemoryMicroscopeMicroscopicMorphologyMusNeuronsOpsinOutputPathway interactionsPatternPerformancePopulationPreparationPyramidal CellsRadialResolutionRouteSiliconTechniquesViralViruscraniumexperimental studyfluorophoreinhibitory neuroninsightmemory consolidationneocorticalnoveloptogeneticspostsynapticpresynapticrecruitsegregationtransmission processvoltage
项目摘要
As synchronous population events SPW-Rs are strongly implicated in the transmission of intra-
hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of
memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells
(CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are
thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent
studies demonstrated the presence of a large degree of morphological and functional
heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the
presence of target-specific functional subdivisions within the hippocampal network. However, the
precise anatomical and functional organization, recruitment mechanisms and behavioral relevance
of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project
4, we will perform an extensive set of new correlational and pertubational experiments which will
provide novel insights into CA1PC target-specific SPW-R organization and function.
作为同步种群事件,SPW-Rs与种群内的传播密切相关
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARK J SCHNITZER的其他文献
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{{ truncateString('MARK J SCHNITZER', 18)}}的其他基金
A robotic multi-armed two-photon microscope for imaging neural interactions across multiple brain areas
机器人多臂双光子显微镜,用于对多个大脑区域的神经相互作用进行成像
- 批准号:
10401607 - 财政年份:2022
- 资助金额:
$ 44.13万 - 项目类别:
A robotic multi-armed two-photon microscope for imaging neural interactions across multiple brain areas
机器人多臂双光子显微镜,用于对多个大脑区域的神经相互作用进行成像
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Multi-color optical voltage imaging of neural activity in behaving animals
行为动物神经活动的多色光学电压成像
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A comprehensive dissection of cell types, circuits and molecular adaptations during opioid use
对阿片类药物使用过程中的细胞类型、回路和分子适应的全面剖析
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- 资助金额:
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使用光学电压成像在基因靶向细胞类型中剖析新皮质场电位动态
- 批准号:
10338619 - 财政年份:2021
- 资助金额:
$ 44.13万 - 项目类别:
Multi-color optical voltage imaging of neural activity in behaving animals
行为动物神经活动的多色光学电压成像
- 批准号:
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- 资助金额:
$ 44.13万 - 项目类别:
A comprehensive dissection of cell types, circuits and molecular adaptations during opioid use
对阿片类药物使用过程中的细胞类型、回路和分子适应的全面剖析
- 批准号:
10302852 - 财政年份:2021
- 资助金额:
$ 44.13万 - 项目类别:
A comprehensive dissection of cell types, circuits and molecular adaptations during opioid use
对阿片类药物使用过程中的细胞类型、回路和分子适应的全面剖析
- 批准号:
10598151 - 财政年份:2021
- 资助金额:
$ 44.13万 - 项目类别:
Large-scale dual-color two-photon calcium imaging in awake behaving animals
清醒行为动物的大规模双色双光子钙成像
- 批准号:
9788541 - 财政年份:2016
- 资助金额:
$ 44.13万 - 项目类别:
Large-scale dual-color two-photon calcium imaging in awake behaving animals
清醒行为动物的大规模双色双光子钙成像
- 批准号:
9346634 - 财政年份:2016
- 资助金额:
$ 44.13万 - 项目类别:
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