Routing of SPW-R content via distinct hippocampal output pathways

通过不同的海马输出途径进行 SPW-R 内容的路由

• 批准号: 10202754
• 负责人: MARK J SCHNITZER
• 金额: $ 44.13万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202754
• 关键词: Affect; Anatomy; Behavior; Behavioral; Calcium; Crystallization; Dependence; Dorsal; Electrophysiology (science); Emotional; Equine mule; Event; Head; Heterogeneity; Hippocampus (Brain); Image; Label; Learning; Location; Mediating; Memory; Microscope; Microscopic; Morphology; Mus; Neurons; Opsin; Output; Pathway interactions; Pattern; Performance; Population; Preparation; Pyramidal Cells; Radial; Resolution; Route; Silicon; Techniques; Viral; Virus; cranium; experimental study; fluorophore; inhibitory neuron; insight; memory consolidation; neocortical; novel; optogenetics; postsynaptic; presynaptic; recruit; segregation; transmission process; voltage

As synchronous population events SPW-Rs are strongly implicated in the transmission of intra- hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells (CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent studies demonstrated the presence of a large degree of morphological and functional heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the presence of target-specific functional subdivisions within the hippocampal network. However, the precise anatomical and functional organization, recruitment mechanisms and behavioral relevance of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project 4, we will perform an extensive set of new correlational and pertubational experiments which will provide novel insights into CA1PC target-specific SPW-R organization and function.

作为同步人口事件SPW-R强烈牵连到内部的传播， 海马体外目标的脑内存储表征，支持 这些目标的记忆。初级海马输出来自CA 1锥体细胞 （CA 1 PC），以及具有特定皮质和皮质下海马外靶点的CA 1 PC。 被认为是差异分布沿着主要海马解剖轴。反过来，最近 研究表明，存在很大程度的形态和功能 沿着这些相同的海马轴，CA 1 PC群体内的异质性，表明 海马网络内存在靶特异性功能亚区。但 精确的解剖和功能组织，招募机制和行为相关性 SPW-R沿着这些海马外靶特异性亚区的分布仍然未知。在项目 4，我们将进行一系列新的相关性和扰动实验， 为CA 1 PC靶特异性SPW-R组织和功能提供了新的见解。