Routing of SPW-R content via distinct hippocampal output pathways

通过不同的海马输出途径进行 SPW-R 内容的路由

• 批准号: 10202754
• 负责人: MARK J SCHNITZER
• 金额: $ 44.13万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202754
• 关键词: Affect; Anatomy; Behavior; Behavioral; Calcium; Crystallization; Dependence; Dorsal; Electrophysiology (science); Emotional; Equine mule; Event; Head; Heterogeneity; Hippocampus (Brain); Image; Label; Learning; Location; Mediating; Memory; Microscope; Microscopic; Morphology; Mus; Neurons; Opsin; Output; Pathway interactions; Pattern; Performance; Population; Preparation; Pyramidal Cells; Radial; Resolution; Route; Silicon; Techniques; Viral; Virus; cranium; experimental study; fluorophore; inhibitory neuron; insight; memory consolidation; neocortical; novel; optogenetics; postsynaptic; presynaptic; recruit; segregation; transmission process; voltage

As synchronous population events SPW-Rs are strongly implicated in the transmission of intra- hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells (CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent studies demonstrated the presence of a large degree of morphological and functional heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the presence of target-specific functional subdivisions within the hippocampal network. However, the precise anatomical and functional organization, recruitment mechanisms and behavioral relevance of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project 4, we will perform an extensive set of new correlational and pertubational experiments which will provide novel insights into CA1PC target-specific SPW-R organization and function.

作为同步的种群事件，SPW-R强烈地牵涉到内部的传播 海马区存储的对海马区外靶点的表征，支持巩固 这些目标的记忆。初级海马区的输出来自CA1区锥体细胞 (CA1PC)，以及具有特定皮质和皮质下海马区外靶点的CA1PC 被认为沿着主要的海马体解剖轴不同地分布。反过来，最近 研究表明，在很大程度上存在形态和功能 CA1PC群体中沿着这些相同的海马轴的异质性，表明 在海马区网络中存在特定靶点的功能分区。然而， 精确的解剖和功能组织、招募机制和行为相关性 SPW-R沿这些海马区外靶点特异性亚区的分布尚不清楚。在项目中 4，我们将进行一系列新的相关和微扰实验 对CA1PC目标特定的SPW-R的组织和功能提供新的见解。