Research Training in Pulmonary Immunology and Allergy at MGH

MGH 肺部免疫学和过敏研究培训

• 批准号: 10202695
• 负责人: David C Christiani
• 金额: $ 67.84万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202695
• 关键词: Hypersensitivity; Immunology; Lung; Research Training

Research Training in Pulmonary Immunology and Allergy at MGH is a T32 renewal application that brings together research programs of the Massachusetts General Hospital (MGH) Division of Pulmonary and Critical Care Medicine (DPCCM), Allergy and Clinical Immunology Unit (ACIU), and Center for Immunology and Inflammatory Diseases (CIID). This Training Program was created principally to provide comprehensive training for physician-scientists in the DPCCM and ACIU fellowship programs interested in lung immunology and allergic inflammation. The Program is designed to prepare the next generations of physician-scientists and PhD-scientists to be leaders in lung immunology and allergy related research. In the first 3.5 years, this Program has been highly successful with no unfilled slots and 100% academic retention. In addition, all of the graduates of the Program have published at least one first-author publication and 73% have secured independent funding. In this renewal application we capitalize on this success and momentum and provide training in 10 scientific disciplines: (i) Adaptive Lung Immunity; (ii) Innate Lung Immunity; (iii) Allergic Sensitization, Tolerance & Immunodeficiency; (iv) Lung Injury, Repair & Regeneration; (v) Molecular Epidemiology & Genetics of Lung Disease and Allergy; (vi) Health Care Delivery Science in Pulmonary and Allergy; (vii) Translational & Precision Medicine; (viii) Systems Biology, Single Cell Genomics & Epigenetics; (ix) Microbiome; (x) Novel Imaging Modalities. The Program will have basic, translational, health outcomes and epidemiology components. Specifically we seek to provide: 1) opportunities for mentored research in disciplines that have the potential for high-impact discoveries; 2) outstanding research training through didactics, seminars, and comprehensive mentoring; and 3) an environment and infrastructure that fosters scholarly activity and career development into independent scientists. This application requests 10 training positions that will be allocated to trainees who are committed to 2 to 3 years of research training. Eight MD or MD/PhD candidates will be drawn from the highly competitive DPCCM and ACIU fellowship programs. Two PhD trainees will be chosen from postdoctoral fellows in the laboratories of our mentors who are performing at a high level and who have demonstrated a commitment to careers in pulmonary or allergy research. Two new slots for PhD trainees are being requested based on trainee and mentor feedback indicating that our Program would be strengthened, and the mission of the NIH better served, by having MDs and PhDs train side-by-side. The 28 mentors in this Program were carefully chosen based on their track record of publications, grants, mentoring, collaboration and interest in lung immunology and allergy. MGH provides an outstanding training environment with over 1400 investigators, numerous training grants, research centers, trainee support groups, and over $850 million in research grant awards. Furthermore, opportunities at Harvard Medical School, the Harvard School of Public Health, and the Broad Institute provide additional valuable resources for trainees.

MGH的肺免疫学和过敏症研究培训是T32更新应用程序， 结合马萨诸塞州总医院（MGH）肺部和危重病科的研究项目， 护理医学（DPCCM），过敏和临床免疫学单位（ACIU），以及免疫学和 炎症性疾病（CIID）。该培训计划主要是为了提供全面的 为对肺部免疫学感兴趣的DPC CM和ACIU奖学金计划中的医生-科学家提供培训 和过敏性炎症。该计划旨在培养下一代的医生-科学家， 博士科学家将成为肺免疫学和过敏相关研究的领导者。在最初的3.5年里， 该计划非常成功，没有空缺，100%的学术保留。此外，所有 该计划的毕业生至少出版了一本第一作者出版物，73%的人获得了 独立融资。在这次更新申请中，我们利用这一成功和势头并提供 在10个科学学科的培训：（一）适应性肺免疫;（二）先天性肺免疫;（三）过敏 致敏、耐受和免疫缺陷;（iv）肺损伤、修复和再生;（v）分子 肺疾病和过敏的流行病学和遗传学;（vi）肺和肺疾病的医疗保健提供科学 （vii）遗传学;（vii）遗传学;（viii）遗传学;（vii）遗传学;（vii）遗传学;（viii）遗传学;（vii）遗传学;（vii）遗传学; (ix)微生物组;（x）新型成像模式。该计划将有基本的，转化的，健康的成果， 流行病学组成部分。具体来说，我们寻求提供：1）指导研究的机会， 具有高影响力发现潜力的学科; 2）通过 教学法、研讨会和全面的指导;以及3）培养 学术活动和职业发展成为独立的科学家。此应用程序要求10次培训 这些职位将分配给致力于2至3年研究培训的学员。8 MD或 MD/PhD候选人将从竞争激烈的DPCCM和ACIU奖学金计划中脱颖而出。两 博士生将从我们的导师实验室的博士后研究员中选出，他们在 高水平，并已证明致力于肺或过敏研究的职业生涯。两个新 根据学员和导师的反馈，我们的项目 通过让医学博士和博士并肩训练，将得到加强，NIH的使命将得到更好的服务。 该计划的28位导师是根据他们的出版物，赠款， 指导、合作和对肺免疫学和过敏的兴趣。MGH提供出色的培训 环境拥有超过1400名调查员，众多的培训赠款，研究中心，学员支持小组， 以及超过8.5亿美元的研究资助。此外，在哈佛医学院， 哈佛公共卫生学院和布罗德研究所为学员提供了额外的宝贵资源。