Research Training in Pulmonary Immunology and Allergy at Massachusetts General Hospital

MGH的肺部免疫学和过敏研究培训是一项T32更新申请，它带来了 马萨诸塞州总医院(MGH)肺科和危重科联合研究计划 护理医学(DPCCM)，过敏和临床免疫科(ACIU)，免疫学和 炎症性疾病。本培训计划主要是为以下人员提供全面的培训 DPCCM和ACIU研究计划中对肺部免疫学和过敏感兴趣的内科科学家 发炎。该项目旨在培养下一代内科科学家和博士- 科学家将成为肺部免疫学和过敏相关研究的领导者。在最初的9年中，该计划已经 非常成功，没有空缺职位，在学术中心或行业中的保留率为100% 研究。此外，除一名前实习生外，所有在3年前完成T32支持的学员都 发表了第一作者论文和提交了拨款申请，并获得了50项研究补助金。在……里面 此次续签申请，我们利用这一成功和势头，在12个科学领域提供培训 学科：(1)适应性肺免疫；(2)先天肺免疫；(3)过敏致敏、耐受和 免疫缺陷；(Iv)肺损伤、修复和再生；(V)肺的分子流行病学和遗传学 疾病和过敏；(Vi)肺部和过敏方面的卫生保健提供科学；(Vii)翻译和精确 医学；(Viii)系统生物学、单细胞基因组学和表观遗传学；(Ix)微生物组；(X)新颖成像 模式；(十一)新陈代谢；(十二)纳米技术和有机类化合物。该计划将有基本的、翻译的、 健康结果和流行病学组成部分。具体地说，我们寻求提供：1)为被指导者提供机会 在具有高影响力发现潜力的学科中进行研究；2)出色的研究培训 通过教学、研讨会和全面指导；以及3)环境和基础设施 促进学术活动和职业发展成为独立的科学家。此应用程序请求一个 续设8个培训职位，分配给致力于2至3年研究的受训人员 训练。医学博士或医学博士候选人将从DPCCM和ACIU奖学金计划中挑选。博士生 将从导师实验室中表现出承诺的博士后研究员中挑选出来 从事肺部或过敏研究的职业。33名导师(12名女性，4名代表不足的少数族裔 医学)是根据他们在出版物、赠款、指导、 对肺部免疫学和过敏症方面的合作和兴趣。MGH提供了杰出的科学和培训 为其2,000多名调查人员和数千名受训人员提供环境，并提供大量培训赠款、研究 中心、受训人员支持团体和超过12亿美元的研究补助金。此外，在 附近的哈佛医学院、哈佛陈公共卫生学院、博德研究所、 麻省理工学院和麻省理工学院为学员提供了更多宝贵的资源。

Research Training in Pulmonary Immunology and Allergy at MGH is a T32 renewal application that brings together research programs of the Massachusetts General Hospital (MGH) Division of Pulmonary and Critical Care Medicine (DPCCM), Allergy and Clinical Immunology Unit (ACIU), and Center for Immunology and Inflammatory Diseases. This Training Program was created principally to provide comprehensive training for physician-scientists in the DPCCM and ACIU fellowship programs interested in lung immunology and allergic inflammation. The Program is designed to prepare the next generations of physician-scientists and PhD- scientists to be leaders in lung immunology and allergy related research. In the first 9 years, this Program has been highly successful with no unfilled slots and 100% rate of retention in academic centers or in industry research. In addition, all but one former trainee who finished their T32 support more than 3 years ago have published first author papers and submitted grant applications, and 50 research grants have been awarded. In this renewal application we capitalize on this success and momentum and provide training in 12 scientific disciplines: (i) Adaptive Lung Immunity; (ii) Innate Lung Immunity; (iii) Allergic Sensitization, Tolerance & Immunodeficiency; (iv) Lung Injury, Repair & Regeneration; (v) Molecular Epidemiology & Genetics of Lung Disease and Allergy; (vi) Health Care Delivery Science in Pulmonary and Allergy; (vii) Translational & Precision Medicine; (viii) Systems Biology, Single Cell Genomics & Epigenetics; (ix) Microbiome; (x) Novel Imaging Modalities; (xi) Metabolism; (xii) and Nanotechnology and Organoids. The Program will have basic, translational, health outcomes and epidemiology components. Specifically, we seek to provide: 1) opportunities for mentored research in disciplines that have the potential for high-impact discoveries; 2) outstanding research training through didactics, seminars, and comprehensive mentoring; and 3) an environment and infrastructure that fosters scholarly activity and career development into independent scientists. This application requests a continuation of 8 training positions that will be allocated to trainees who are committed to 2 to 3 years of research training. MD or MD/PhD candidates will be drawn from the DPCCM and ACIU fellowship programs. PhD trainees will be chosen from postdoctoral fellows in the mentor laboratories who have demonstrated a commitment to careers in pulmonary or allergy research. The 33 mentors (12 women, 4 underrepresented minorities in medicine) in this Program were carefully chosen based on their track record of publications, grants, mentoring, collaboration and interest in lung immunology and allergy. MGH provides an outstanding scientific and training environment for its over 2,000 investigators and thousands of trainees with numerous training grants, research centers, trainee support groups and over $1.2 billion in research grant awards. Furthermore, opportunities at the nearby Harvard Medical School, the Harvard Chan School of Public Health, the Broad Institute, the Ragon Institute and Massachusetts Institute of Technology provide additional valuable resources for trainees.