Research Training in Pulmonary Immunology and Allergy at MGH

描述（申请人提供）：MGH的肺部免疫学和过敏症研究培训是一个新的T32应用程序，由Andrew Luster和大卫Christiani博士指导，汇集了马萨诸塞州总医院（MGH）免疫学和炎症性疾病中心（CIID），肺部和重症监护室（PCCU），和过敏和临床免疫学单位（ACIU）。多年来，PCCU和ACIU已经有单独的成功的T32培训计划，但随着CIID的形成，现在有一个共同的研究努力，在肺免疫学和过敏与教师在PCCU和ACIU。因此，有理由认为，合并成一个单一的培训计划，集中在肺免疫学和过敏性炎症将改善培训，提供一个更全面的培训计划，为医生-科学家在PCCU和ACIU奖学金计划。该培训计划旨在培养下一代医生科学家，他们通过指导研究和新技术的严格培训，准备成为肺免疫学和过敏相关生物医学研究的领导者。我们将强调8个科学学科的培训：细胞运输，成像，肺部炎症， 先天免疫、粘膜免疫、变态反应、系统生物学和流行病学。该计划将有基本和翻译的组成部分。具体来说，我们寻求提供：1）在具有高影响力发现潜力的学科中进行指导研究的机会; 2）通过教学法，研讨会和全面指导进行出色的研究培训; 3）促进学术活动和职业发展的环境和基础设施独立的医生-科学家。该申请要求在第一年有4个培训职位，在第二年到第五年有8个培训职位，这些职位将分配给致力于完成2到3年研究培训的学员。候选人将从哈佛大学的肺和重症监护医学联合奖学金，这是基于MGH，过敏和免疫学奖学金在MGH。学员根据该计划执行委员会达成的共识被接受加入该计划，该委员会包括该计划的主任Luster博士和Christiani以及该计划的联合主任Medoff博士和Shreffler。20名导师隶属于该培训计划，并根据他们的出版记录，赠款，指导，合作和对肺部免疫学和过敏的共同兴趣以及其中新研究人员的培训而精心挑选。MGH提供了一个优秀的培训环境，拥有1400多名研究人员，众多的T32培训赠款，专题研究中心，学员支持小组，以及超过7亿美元的NIH研究补助金。此外，哈佛大学的机会，包括课程工作和哈佛临床和转化科学中心（NIH资助的临床和转化科学奖联盟的成员）为学员提供了额外的宝贵资源。

DESCRIPTION (provided by applicant): Research Training in Pulmonary Immunology and Allergy at MGH is a new T32 application, directed by Drs. Andrew Luster and David Christiani, that brings together the research programs of the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID), Pulmonary and Critical Care Unit (PCCU), and the Allergy and Clinical Immunology Unit (ACIU).For many years the PCCU and the ACIU have had separate successful T32 training programs, but with the formation of the CIID there is now a joint research effort on pulmonary immunology and allergy with faculty in both the PCCU and ACIU. Thus, it was reasoned that merging into a single training program that concentrated on lung immunology and allergic inflammation will improve training by providing a more comprehensive training program for physician- scientists in the PCCU and ACIU fellowship programs. The Training Program is designed to prepare the next generation of physician-scientists who, through mentored research and rigorous training in new technologies, are prepared to be leaders in pulmonary immunology and allergy related biomedical research. We will emphasize training in8scientific disciplines: cell trafficking, imaging, lung inflammation, innate immunity, mucosal immunity, allergy, systems biology, and epidemiology. The Program will have both basic and translational components. Specifically we seek to provide: 1) opportunities for mentored research in disciplines that have the potential for high-impact discoveries; 2) outstanding research training through didactics, seminars, and comprehensive mentoring; and 3) an environment and infrastructure that fosters scholarly activity and career development into independent physician- scientists. This application requests 4 training positions in year one and 8 in years two through five that will be allocated to trainees who are committed to a full 2 to 3 years of research training. The candidates will be drawn from the Harvard-combined fellowship in Pulmonary and Critical Care Medicine, which is based at MGH, and the Allergy and Immunology Fellowship at MGH. Trainees are accepted into the Program based on a consensus reached by the Program's Executive Committee, which includes the Program Directors, Drs. Luster and Christiani, and the Program's Co-Directors, Drs. Medoff and Shreffler. Twenty mentors are affiliated with this Training Program and were carefully chosen based on their track record of publication, grants, mentoring, collaboration and a mutual interest in lung immunology and allergy and the training of new investigators therein. The MGH provides an outstanding training environment with over 1400 investigators, numerous T32 training grants, thematic research centers, trainee support groups, and over $700 million in NIH research grant awards. Furthermore, opportunities at Harvard University, including course work and the Harvard Clinical and Translational Science Center (a member of the NIH-funded Clinical and Translational Science Award Consortium) provide additional valuable resources for trainees.