Research Training in Pulmonary Immunology and Allergy at MGH

描述(申请人提供)：MGH的肺部免疫学和过敏研究培训是一项新的T32应用，由Andrew Luster和David Christian博士指导，汇集了马萨诸塞州综合医院(MGH)免疫和炎症性疾病中心(CIID)、肺和重症监护病房(PCCU)以及过敏和临床免疫科(ACIU)的研究计划。多年来，PCCU和ACIU有单独的成功的T32培训计划，但随着CIID的成立，现在有一个关于肺部免疫学和过敏的联合研究工作，在PCCU和ACIU的教员。因此，合并成一个专注于肺部免疫学和过敏性炎症的单一培训计划将通过为PCCU和ACIU奖学金计划中的内科科学家提供更全面的培训计划来改进培训。该培训计划旨在培养下一代内科科学家，他们通过新技术方面的指导研究和严格培训，准备成为肺部免疫学和过敏相关生物医学研究的领导者。我们将强调8个科学学科的培训：细胞贩运、成像、肺部炎症、 先天免疫、粘膜免疫、过敏、系统生物学和流行病学。该计划将包括基本部分和翻译部分。具体地说，我们寻求提供：1)在有可能产生重大影响的发现的学科中提供指导研究的机会；2)通过教学、研讨会和综合指导提供出色的研究培训；以及3)促进学术活动和职业发展成为独立的内科科学家的环境和基础设施。本申请申请第一年的4个培训职位和第二至五年的第八个培训职位，这些职位将分配给致力于完整的2至3年研究培训的受训者。候选人将从总部设在MGH的哈佛大学肺部和危重护理医学联合奖学金和MGH过敏和免疫学奖学金中挑选出来。学员是根据项目执行委员会达成的共识接受的，执行委员会包括项目主任卢斯特博士和克里斯塔尼博士，以及项目联席主任梅多夫博士和施雷夫勒博士。20名导师隶属于这一培训计划，他们是根据他们的出版、赠款、指导、合作以及对肺部免疫学和过敏以及对新研究人员的培训的共同兴趣而精心挑选的。麻省理工学院提供了一个出色的培训环境，有1400多名研究人员，无数的T32培训补助金，专题研究中心，学员支持小组，以及超过7亿美元的NIH研究补助金。此外，哈佛大学的机会，包括课程工作和哈佛临床和翻译科学中心(NIH资助的临床和翻译科学奖联盟的成员之一)为学员提供了额外的宝贵资源。

DESCRIPTION (provided by applicant): Research Training in Pulmonary Immunology and Allergy at MGH is a new T32 application, directed by Drs. Andrew Luster and David Christiani, that brings together the research programs of the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID), Pulmonary and Critical Care Unit (PCCU), and the Allergy and Clinical Immunology Unit (ACIU).For many years the PCCU and the ACIU have had separate successful T32 training programs, but with the formation of the CIID there is now a joint research effort on pulmonary immunology and allergy with faculty in both the PCCU and ACIU. Thus, it was reasoned that merging into a single training program that concentrated on lung immunology and allergic inflammation will improve training by providing a more comprehensive training program for physician- scientists in the PCCU and ACIU fellowship programs. The Training Program is designed to prepare the next generation of physician-scientists who, through mentored research and rigorous training in new technologies, are prepared to be leaders in pulmonary immunology and allergy related biomedical research. We will emphasize training in8scientific disciplines: cell trafficking, imaging, lung inflammation, innate immunity, mucosal immunity, allergy, systems biology, and epidemiology. The Program will have both basic and translational components. Specifically we seek to provide: 1) opportunities for mentored research in disciplines that have the potential for high-impact discoveries; 2) outstanding research training through didactics, seminars, and comprehensive mentoring; and 3) an environment and infrastructure that fosters scholarly activity and career development into independent physician- scientists. This application requests 4 training positions in year one and 8 in years two through five that will be allocated to trainees who are committed to a full 2 to 3 years of research training. The candidates will be drawn from the Harvard-combined fellowship in Pulmonary and Critical Care Medicine, which is based at MGH, and the Allergy and Immunology Fellowship at MGH. Trainees are accepted into the Program based on a consensus reached by the Program's Executive Committee, which includes the Program Directors, Drs. Luster and Christiani, and the Program's Co-Directors, Drs. Medoff and Shreffler. Twenty mentors are affiliated with this Training Program and were carefully chosen based on their track record of publication, grants, mentoring, collaboration and a mutual interest in lung immunology and allergy and the training of new investigators therein. The MGH provides an outstanding training environment with over 1400 investigators, numerous T32 training grants, thematic research centers, trainee support groups, and over $700 million in NIH research grant awards. Furthermore, opportunities at Harvard University, including course work and the Harvard Clinical and Translational Science Center (a member of the NIH-funded Clinical and Translational Science Award Consortium) provide additional valuable resources for trainees.