Research Training in Pulmonary Immunology and Allergy at MGH

MGH的肺部免疫学和过敏研究培训是一项T32更新申请，它带来了 马萨诸塞州总医院(MGH)肺科和危重科联合研究计划 护理医学(DPCCM)，过敏和临床免疫科(ACIU)，免疫学和 炎症性疾病(CIID)该培训计划的创建主要是为了提供全面的 对对肺部免疫学感兴趣的DPCCM和ACIU奖学金计划的内科科学家进行培训 和过敏性炎症。该计划旨在为下一代内科科学家和 博士-科学家将成为肺部免疫学和过敏相关研究的领导者。在最初的3.5年里，这个 该计划非常成功，没有空缺的职位，100%的学术保留。此外，所有的 该项目的毕业生至少出版了一本第一作者的出版物，73%的人获得了 独立资助。在这次续订申请中，我们利用这一成功和势头，并提供 10个科学学科的培训：(1)适应性肺免疫；(2)先天肺免疫；(3)过敏 致敏、耐受和免疫缺陷；(Iv)肺损伤、修复和再生；(V)分子 肺部疾病和过敏的流行病学和遗传学；(Vi)肺病和变态反应的卫生保健提供科学 过敏；(Vii)转译和精密医学；(Viii)系统生物学、单细胞基因组学和表观遗传学； (九)微生物组；(十)新的成像模式。该计划将有基本的、转化的、健康的结果和 流行病学部分。具体地说，我们寻求提供：1)有指导的研究机会 具有高影响力发现潜力的学科；2)通过以下途径进行杰出的研究培训 教学、研讨会和全面指导；以及3)促进 学术活动和职业发展成为独立的科学家。此应用程序需要10个培训 将分配给致力于2至3年研究培训的受训者的职位。八个医学博士或 博士/博士候选人将从竞争激烈的DPCCM和ACIU奖学金项目中挑选出来。二 博士生将从我们导师的实验室博士后研究员中挑选出来，他们在 具有较高水平，并致力于从事肺部或过敏研究的人员。两个新的 根据实习生和导师的反馈，我们正在申请博士生的名额 通过让博士和博士同时接受培训，将得到加强，更好地服务于NIH的使命。 该计划中的28位导师是根据他们在出版物、赠款、 对肺部免疫学和过敏症的指导、合作和兴趣。MGH提供出色的培训 拥有1400多名调查人员、大量培训补助金、研究中心、学员支持小组、 以及超过8.5亿美元的研究拨款。此外，哈佛医学院的机会， 哈佛大学公共卫生学院和布罗德研究所为学员提供了更多宝贵的资源。

Research Training in Pulmonary Immunology and Allergy at MGH is a T32 renewal application that brings together research programs of the Massachusetts General Hospital (MGH) Division of Pulmonary and Critical Care Medicine (DPCCM), Allergy and Clinical Immunology Unit (ACIU), and Center for Immunology and Inflammatory Diseases (CIID). This Training Program was created principally to provide comprehensive training for physician-scientists in the DPCCM and ACIU fellowship programs interested in lung immunology and allergic inflammation. The Program is designed to prepare the next generations of physician-scientists and PhD-scientists to be leaders in lung immunology and allergy related research. In the first 3.5 years, this Program has been highly successful with no unfilled slots and 100% academic retention. In addition, all of the graduates of the Program have published at least one first-author publication and 73% have secured independent funding. In this renewal application we capitalize on this success and momentum and provide training in 10 scientific disciplines: (i) Adaptive Lung Immunity; (ii) Innate Lung Immunity; (iii) Allergic Sensitization, Tolerance & Immunodeficiency; (iv) Lung Injury, Repair & Regeneration; (v) Molecular Epidemiology & Genetics of Lung Disease and Allergy; (vi) Health Care Delivery Science in Pulmonary and Allergy; (vii) Translational & Precision Medicine; (viii) Systems Biology, Single Cell Genomics & Epigenetics; (ix) Microbiome; (x) Novel Imaging Modalities. The Program will have basic, translational, health outcomes and epidemiology components. Specifically we seek to provide: 1) opportunities for mentored research in disciplines that have the potential for high-impact discoveries; 2) outstanding research training through didactics, seminars, and comprehensive mentoring; and 3) an environment and infrastructure that fosters scholarly activity and career development into independent scientists. This application requests 10 training positions that will be allocated to trainees who are committed to 2 to 3 years of research training. Eight MD or MD/PhD candidates will be drawn from the highly competitive DPCCM and ACIU fellowship programs. Two PhD trainees will be chosen from postdoctoral fellows in the laboratories of our mentors who are performing at a high level and who have demonstrated a commitment to careers in pulmonary or allergy research. Two new slots for PhD trainees are being requested based on trainee and mentor feedback indicating that our Program would be strengthened, and the mission of the NIH better served, by having MDs and PhDs train side-by-side. The 28 mentors in this Program were carefully chosen based on their track record of publications, grants, mentoring, collaboration and interest in lung immunology and allergy. MGH provides an outstanding training environment with over 1400 investigators, numerous training grants, research centers, trainee support groups, and over $850 million in research grant awards. Furthermore, opportunities at Harvard Medical School, the Harvard School of Public Health, and the Broad Institute provide additional valuable resources for trainees.